scholarly journals Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis

2012 ◽  
Vol 32 (9) ◽  
pp. 1643-1644
Author(s):  
Malcolm R Macleod
Keyword(s):  
Systematic Review ◽  
Subarachnoid Hemorrhage ◽  
Meta Analysis ◽  
Angiographic Vasospasm ◽  
Experimental Subarachnoid Hemorrhage

scholarly journals Pharmacologic Reduction of Angiographic Vasospasm in Experimental Subarachnoid Hemorrhage: Systematic Review and Meta-Analysis

2012 ◽  
Vol 32 (9) ◽  
pp. 1645-1658 ◽  
Author(s):  
Tommaso Zoerle ◽  
Don C Ilodigwe ◽  
Hoyee Wan ◽  
Katarina Lakovic ◽  
Mohammed Sabri ◽  
...  
Keyword(s):  
Systematic Review ◽  
Subarachnoid Hemorrhage ◽  
Animal Models ◽  
Animal Studies ◽  
Meta Analysis ◽  
Angiographic Vasospasm ◽  
Standard Mean Difference ◽  
Methodologic Quality ◽  
Experimental Subarachnoid Hemorrhage ◽  
Pharmacologic Treatments

Animal models have been developed to simulate angiographic vasospasm secondary to subarachnoid hemorrhage (SAH) and to test pharmacologic treatments. Our aim was to evaluate the effect of pharmacologic treatments that have been tested in humans and in preclinical studies to determine if animal models inform results reported in humans. A systematic review and meta-analysis of SAH studies was performed. We investigated predictors of translation from animals to humans with multivariate logistic regression. Pharmacologic reduction of vasospasm was effective in mice, rats, rabbits, dogs, nonhuman primates (standard mean difference of −1.74; 95% confidence interval −2.04 to −1.44) and humans. Animal studies were generally of poor methodologic quality and there was evidence of publication bias. Subgroup analysis by drug and species showed that statins, tissue plasminogen activator, erythropoietin, endothelin receptor antagonists, calcium channel antagonists, fasudil, and tirilazad were effective whereas magnesium was not. Only evaluation of vasospasm >3 days after SAH was independently associated with successful translation. We conclude that reduction of vasospasm is effective in animals and humans and that evaluation of vasospasm >3 days after SAH may be preferable for preclinical models.

Ultra-Early Angiographic Vasospasm After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 102 ◽  
pp. 632-638.e1 ◽  
Author(s):  
Kevin Phan ◽  
Justin M. Moore ◽  
Christoph J. Griessenauer ◽  
Joshua Xu ◽  
Ian Teng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Subarachnoid Hemorrhage ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Meta Analysis ◽  
Angiographic Vasospasm

scholarly journals Anxiety after subarachnoid hemorrhage: A systematic review and meta-analysis

2021 ◽  
Vol 3 ◽  
pp. 100060
Author(s):  
Wai Kwong Tang ◽  
Lisha Wang ◽  
Kelvin KF Tsoi ◽  
Jae Min Kim ◽  
Sung-Jae Lee ◽  
...  
Keyword(s):  
Systematic Review ◽  
Subarachnoid Hemorrhage ◽  
Meta Analysis
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