scholarly journals The 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function

2007 ◽  
Vol 27 (1_suppl) ◽  
pp. BO01-01-BP59-08H
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
International Symposium ◽  
And Function

scholarly journals Accelerated brain aging and cerebral blood flow reduction in persons with HIV

2021 ◽  
Author(s):  
Kalen J Petersen ◽  
Nicholas Metcalf ◽  
Sarah Cooley ◽  
Dimitre Tomov ◽  
Florin Vaida ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Aging ◽  
Learning Algorithm ◽  
Psychomotor Speed ◽  
Deep Learning Algorithm ◽  
Blood Flow Reduction ◽  
Brain Structure And Function ◽  
N 93 ◽  
And Function

Abstract Background Persons with HIV (PWH) are characterized by altered brain structure and function. As they attain normal lifespans, it has become crucial to understand potential interactions between HIV and aging. However, it remains unclear how brain aging varies with viral load (VL). Methods In this study, we compare MRI biomarkers amongst PWH with undetectable VL (UVL; ≤50 genomic copies/ml; n=230), PWH with detectable VL (DVL; >50 copies/ml; n=93), and HIV uninfected (HIV-) controls (n=206). To quantify gray matter cerebral blood flow (CBF), we utilized arterial spin labeling. To measure structural aging, we used a publicly available deep learning algorithm to estimate brain age from T1-weighted MRI. Cognitive performance was measured using a neuropsychological battery covering five domains. Results Associations between age and CBF varied with VL. Older PWH with DVL had reduced CBF vs. PWH with UVL (p=0.02). Structurally predicted brain aging was accelerated in PWH vs. HIV- controls regardless of VL (p<0.001). Overall, PWH had impaired learning, executive function, psychomotor speed, and language compared to HIV- controls. Structural brain aging was associated with reduced psychomotor speed (p<0.001). Conclusions Brain aging in HIV is multifaceted. CBF depends on age and current VL, and is improved by medication adherence. By contrast, structural aging is an indicator of cognitive function and reflects serostatus rather than current VL.

scholarly journals Noninvasive Optical Monitoring of Cerebral Blood Flow and EEG Spectral Responses after Severe Traumatic Brain Injury: A Case Report

2021 ◽  
Vol 11 (8) ◽  
pp. 1093
Author(s):  
Chien-Sing Poon ◽  
Benjamin Rinehart ◽  
Dharminder S. Langri ◽  
Timothy M. Rambo ◽  
Aaron J. Miller ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Brain Activity ◽  
Correlation Spectroscopy ◽  
Secondary Brain Injury ◽  
Diffuse Correlation Spectroscopy ◽  
Flow Monitoring ◽  
And Function

Survivors of severe brain injury may require care in a neurointensive care unit (neuro-ICU), where the brain is vulnerable to secondary brain injury. Thus, there is a need for noninvasive, bedside, continuous cerebral blood flow monitoring approaches in the neuro-ICU. Our goal is to address this need through combined measurements of EEG and functional optical spectroscopy (EEG-Optical) instrumentation and analysis to provide a complementary fusion of data about brain activity and function. We utilized the diffuse correlation spectroscopy method for assessing cerebral blood flow at the neuro-ICU in a patient with traumatic brain injury. The present case demonstrates the feasibility of continuous recording of noninvasive cerebral blood flow transients that correlated well with the gold-standard invasive measurements and with the frequency content changes in the EEG data.

Eleventh International Symposium on Cerebral Blood Flow and Metabolism

1984 ◽  
Vol 22 (1) ◽  
pp. 100
Author(s):  
Antonio R. Prats ◽  
George T. Tindall
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
International Symposium

The dissociation of cerebral blood flow, metabolism, and function in the early stages of developing cerebral infarction

1980 ◽  
Vol 8 (3) ◽  
pp. 278-290 ◽  
Author(s):  
K. Kogure ◽  
R. Busto ◽  
R. J. Schwartzman ◽  
P. Scheinberg
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Infarction ◽  
Early Stages ◽  
And Function
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