scholarly journals Comparison of the Effects of Intravenous Papaverine Hydrochloride and Oral Pavabid HP Capsulets on Regional Cerebral Blood Flow in Normal Individuals

1983 ◽  
Vol 3 (4) ◽  
pp. 442-447 ◽  
Author(s):  
Lawrence C. McHenry ◽  
David A. Stump ◽  
George Howard ◽  
Thomas T. Novack ◽  
Don H. Bivins ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Subjects ◽  
Normal Male ◽  
Regional Cerebral Blood ◽  
Normal Individuals ◽  
Left And Right ◽  
Male Subjects ◽  
Papaverine Hydrochloride

A single-blind study was conducted in 13 right-handed normal male subjects to compare the effects of oral and i.v. papaverine on regional cerebral blood flow (rCBF). Six xenon-133 inhalation rCBF measurements were performed on each subject; three tests—baseline, placebo, and drug evaluations—were carried out on each of two separate days. The oral and i.v. drugs were randomized for first-day administration. rCBF, measured as flow gray (FG), increased significantly (p ≤ 0.001) from baseline with both drug forms. Increases of 10.53% and 13.94% (left and right hemispheres, respectively) were demonstrated 90 min after a single 600-mg dose of oral papaverine. Increases of 5.09% and 8.69%, respectively, were recorded immediately after a single 100-mg dose of i. v. papaverine. FG also increased significantly (p ≤ 0.001) for both drug forms when compared to that of placebo. Placebo produced only a slight increase (not significant) with both the oral and i.v. groups. The data show that both oral and i.v. papaverine are equally effective in increasing rCBF in normal subjects.

Regional cerebral blood flow asymmetries in a group of 189 normal subjects at rest

1991 ◽  
Vol 4 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Guido Rodriguez ◽  
Richard Coppola ◽  
Fabrizio De Carli ◽  
Stefano Francione ◽  
Stefano Marenco ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Subjects ◽  
Regional Cerebral Blood

scholarly journals Effects of tDCS Dose and Electrode Montage on regional cerebral blood flow and motor behavior

2021 ◽  
Author(s):  
Anant Shinde ◽  
Karl Lerud ◽  
Fanny Munsch ◽  
David C Alsop ◽  
Gottfried Schlaug
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Brain Regions ◽  
Regional Cerebral Blood ◽  
Left Hand ◽  
Motor Region ◽  
Left And Right ◽  
The Right ◽  
Sequence Performance

AbstractWe used three dose levels (Sham, 2mA and 4mA) and two different electrode montages (unihemispheric or bihemispheric) to examine DOSE and MONTAGE effects on regional cerebral blood flow (rCBF) as a surrogate marker of neural activity, and on a finger sequence task, as a surrogate behavioral measure drawing on brain regions targeted by transcranial direct current stimulation (tDCS). We placed the anodal electrode over the right motor region (C4) while the cathodal or return electrode was placed either over a left supraorbital region (unihemispheric montage) or over the left motor region (C3 in the bihemispheric montage). Performance changes in the finger sequence task for both hands (left hand: p = 0.0026, and right hand: p = 0.0002) showed a linear tDCS dose response, but no effect of montage. rCBF in the the right hemispheric perirolandic area increased with dose under the anodal electrode (p = 0.027), while in the perirolandic ROI in the left hemisphere, rCBF showed a trend to increase with dose (p = 0.053), and significant effect of montage (p = 0.00004). The bihemispheric montage showed additional rCBF increases in frontomesial regions in the 4mA condition but not in the 2mA condition. Furthermore, we found correlations between rCBF changes in the right perirolandic region and improvements in the finger sequence task performance (FSP) for left and right hand. Our data support not only a strong direct tDCS dose effect for rCBF and FSP as surrogate measures of targeted brain regions, but also indirect effects on rCBF in functionally connected regions (e.g., frontomesial regions), particularly in the higher dose condition, and on FSP of the ipsilateral hand (to the anodal electrode). At higher dose and irrespective of polarity, a wider network of sensorimotor regions is positively affected by tDCS.Graphical AbstractHighlightstDCS-DOSE had linear effect on finger sequence performance for both handsrCBF changes in both perirolandic ROIs demonstrated tDCS-DOSE effects and left perirolandic ROI demonstrated tDCS-MONTAGE effects.Simulated current intensity in the left and right perirolandic ROI strongly correlated with the contralateral hand’s finger sequence performance.tDCS-Tolerability scores did not correlate with change in rCBF or finger sequence performance of the left hand.

scholarly journals Relationship between Autistic Spectrum Trait and Regional Cerebral Blood Flow in Healthy Male Subjects

2018 ◽  
Vol 15 (10) ◽  
pp. 956-961 ◽  
Author(s):  
Miho Ota ◽  
Junko Matsuo ◽  
Noriko Sato ◽  
Toshiya Teraishi ◽  
Hiroaki Hori ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Healthy Male ◽  
Regional Cerebral Blood ◽  
Autistic Spectrum ◽  
Male Subjects

Left-right cortical asymmetries of regional cerebral blood flow during listening to words

1982 ◽  
Vol 48 (2) ◽  
pp. 458-466 ◽  
Author(s):  
Y. Nishizawa ◽  
T. S. Olsen ◽  
B. Larsen ◽  
N. A. Lassen
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Temporal Region ◽  
Regional Cerebral Blood ◽  
Left And Right ◽  
Sound Discrimination ◽  
Listening Task ◽  
The Right ◽  
Verbal Stimulation

1. Regional cerebral blood flow (rCBF) was measured during rest and during listening to simple words. The xenon-133 intracarotid technique was used and results were obtained from 254 regions of seven right hemispheres and seven left hemispheres. The measurements were performed just after carotid angiography, carried out to exclude space occupying lesions. In all subjects the angiogram was normal. All were right handed. 2. Mean hemispheric blood flow of both left and right hemispheres increased 10% from the resting measurement during the listening task. This increase was due in part to activation of the entire hemisphere. The focal rCBF increases were localized to the superior part of the temporal regions, the prefrontal regions, the frontal eye fields, and the orbitofrontal regions. Significant asymmetries were found in particular in the superior temporal region with the left side showing a more widespread and intense increase, averaging 29% as compared to 18% on the right side. This left-sided dominance during verbal stimulation should be compared to the right-sided dominance of rCBF during nonverbal sound discrimination reported by Roland et al. (25, 26), who used precisely the same technique as in the present study.

Regional Cerebral Blood Flow and Lateralized Hemispheric Dysfunction in Depression

1983 ◽  
Vol 143 (2) ◽  
pp. 128-132 ◽  
Author(s):  
P. Uytdenhoef ◽  
P. Portelange ◽  
J. Jacquy ◽  
G. Charles ◽  
P. Linkowski ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Major Depression ◽  
Regional Cerebral Blood Flow ◽  
Cerebral Metabolism ◽  
Normal Subjects ◽  
Regional Cerebral Blood ◽  
Cerebral Dysfunction ◽  
Bipolar Patients

SummaryCerebral blood flow is known as an indicator of cerebral metabolism. Using the 133Xenon inhalation method, we studied the regional cerebral blood flow (r-CBF) in patients with different subtypes of depression and in remission. A left frontal hypervascularization and a right posterior hypovascularization were found in major depressives, compared to normal subjects, minor depressives, and normothymic bipolar patients. These results tend to confirm the existence of cerebral dysfunction in both hemispheres in major depression, as reported by other authors using different techniques.

scholarly journals Effects of Dextromethorphan on Regional Cerebral Blood Flow in Focal Cerebral Ischemia

1991 ◽  
Vol 11 (5) ◽  
pp. 803-809 ◽  
Author(s):  
Eng H. Lo ◽  
Gary K. Steinberg
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Ischemia ◽  
Frequency Distribution ◽  
Regional Cerebral Blood Flow ◽  
Neuronal Damage ◽  
Focal Cerebral Ischemia ◽  
Distribution Analysis ◽  
Regional Cerebral Blood ◽  
Left And Right

Dextromethorphan (DM), a noncompetitive NMDA antagonist, has been demonstrated to reduce ischemic neuronal damage and edema, but DM's influence on cerebral blood flow has not been extensively studied. In this investigation, it is shown that DM has significant effects on regional cerebral blood flow (rCBF) patterns in a rabbit model of focal cerebral ischemia. rCBF was measured using radioactive microspheres following a 1 h permanent occlusion of the left internal carotid, anterior cerebral, and middle cerebral arteries in rabbits. Somatosensory evoked potentials (SEPs) were used to assess the degree of ischemia; only animals where SEPs were completely abolished were used for a frequency distribution analysis of rCBF. It was found that there were significantly more regions with lower flows in animals treated with normal saline (NS) ( n = 7) compared to animals treated with DM ( n = 7) ( p < 0.05, ipsilateral left side; p < 0.001, contralateral right side). The frequency distribution medians were 27.5 ml 100 g−1 min −1 (left) and 70.0 ml 100 g−1 min−1 (right) in the NS group vs. 34.5 ml 100 g−1 min−1 (left) and 80.5 ml 100 g−1 min−1 (right) in the DM group. The left and right hemispheric regional means were 29.4 ± 20 and 74.3 ± 23 ml 100 g−1 min−1, respectively, in the NS group vs. 34.4 ± 16 and 91.0 ± 28 ml 100 g−1 min−1, respectively, in the DM group. However, there were no significant differences in global CBF between the NS group (33.1 ± 18 and 79.2 ± 20 ml 100 g−1 min−1) and the DM group (35.0 ± 10 and 92.0 ± 21 ml 100 g−1 min−1) in both left and right hemispheres, respectively. These results demonstrate that DM has effects on rCBF in focal cerebral ischemia, although it is unclear if these changes represent primary effects of DM on cerebrovascular function, or secondary effects of neuronal protection.

scholarly journals The C15O2 Build-up Technique to Measure Regional Cerebral Blood Flow and Volume of Distribution of Water

1989 ◽  
Vol 9 (4) ◽  
pp. 461-470 ◽  
Author(s):  
Adriaan A. Lammertsma ◽  
Richard S. J. Frackowiak ◽  
John M. Hoffman ◽  
Sung-Cheng Huang ◽  
Irving N. Weinberg ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Normal Subjects ◽  
Volume Of Distribution ◽  
Regional Cerebral Blood ◽  
Arterial Concentration ◽  
Fixed Distribution

A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centres on recording the tissue build-up and retention of 15O-labelled water during the continuous inhalation of 15O-labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques.

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