Three novel polyene macrolides isolated from cultures of Streptomyces lavenduligriseus

2015 ◽  
Vol 69 (1) ◽  
pp. 62-65 ◽  
Author(s):  
Jiayue Yang ◽  
Zhijun Yang ◽  
Yu Yin ◽  
Min Rao ◽  
Yongheng Liang ◽  
...  
Keyword(s):  
Polyene Macrolides

scholarly journals Identification and Predictions Regarding the Biosynthesis Pathway of Polyene Macrolides Produced by Streptomyces roseoflavus Men-myco-93-63

2021 ◽  
Vol 87 (10) ◽  
Author(s):  
Xing Han ◽  
Jiao Wang ◽  
Lianna Liu ◽  
Fengying Shen ◽  
Qingfang Meng ◽  
...  
Keyword(s):  
Fermentation Broth ◽  
Pathogenic Fungi ◽  
Biosynthetic Gene Cluster ◽  
Inhibitory Effect ◽  
Plant Diseases ◽  
Active Metabolites ◽  
Content Type ◽  
Polyene Macrolides ◽  
Alternative Agent

ABSTRACT A group of polyene macrolides mainly composed of two constituents was isolated from the fermentation broth of Streptomyces roseoflavus Men-myco-93-63, which was isolated from soil where potato scabs were repressed naturally. One of these macrolides was roflamycoin, which was first reported in 1968, and the other was a novel compound named Men-myco-A, which had one methylene unit more than roflamycoin. Together, they were designated RM. This group of antibiotics exhibited broad-spectrum antifungal activities in vitro against 17 plant-pathogenic fungi, with 50% effective concentrations (EC50) of 2.05 to 7.09 μg/ml and 90% effective concentrations (EC90) of 4.32 to 54.45 μg/ml, which indicates their potential use in plant disease control. Furthermore, their biosynthetic gene cluster was identified, and the associated biosynthetic assembly line was proposed based on a module and domain analysis of polyketide synthases (PKSs), supported by findings from gene inactivation experiments. IMPORTANCE Streptomyces roseoflavus Men-myco-93-63 is a biocontrol strain that has been studied in our laboratory for many years and exhibits a good inhibitory effect in many crop diseases. Therefore, the identification of antimicrobial metabolites is necessary and our main objective. In this work, chemical, bioinformatic, and molecular biological methods were combined to identify the structures and biosynthesis of the active metabolites. This work provides a new alternative agent for the biological control of plant diseases and is helpful for improving both the properties and yield of the antibiotics via genetic engineering.

The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi

2019 ◽  
Vol 21 (12) ◽  
pp. 4788-4792 ◽  
Author(s):  
Yohei Morishita ◽  
Huiping Zhang ◽  
Tohru Taniguchi ◽  
Keiji Mori ◽  
Teigo Asai
Keyword(s):  
Polyene Macrolides

Total Synthesis of Iejimalide A−D and Assessment of the Remarkable Actin-Depolymerizing Capacity of These Polyene Macrolides

2007 ◽  
Vol 129 (29) ◽  
pp. 9150-9161 ◽  
Author(s):  
Alois Fürstner ◽  
Cristina Nevado ◽  
Mario Waser ◽  
Martin Tremblay ◽  
Carine Chevrier ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Polyene Macrolides

A synthetic approach to polyene macrolides. Macrolide and polyene generation

1986 ◽  
Vol 27 (47) ◽  
pp. 5695-5698 ◽  
Author(s):  
Barry M. Trost ◽  
Jeffrey T. Hane ◽  
Peter Metz
Keyword(s):  
Synthetic Approach ◽  
Polyene Macrolides
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