scholarly journals Growth inhibitory response and ultrastructural modification of oral-associated candidal reference strains (ATCC) by Piper betle L. extract

2014 ◽  
Vol 6 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Mohd-Al-Faisal Nordin ◽  
Wan Himratul-Aznita Wan Harun ◽  
Fathilah Abdul Razak ◽  
Md Yusoff Musa
Keyword(s):  
Inhibitory Response ◽  
Piper Betle ◽  
Growth Inhibitory ◽  
Reference Strains ◽  
Ultrastructural Modification

scholarly journals Expression of GATA3 in MDA-MB-231 Triple-negative Breast Cancer Cells Induces a Growth Inhibitory Response to TGFß

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61125 ◽  
Author(s):  
Isabel M. Chu ◽  
Wei-Chu Lai ◽  
Olga Aprelikova ◽  
Lara H. El Touny ◽  
Hosein Kouros-Mehr ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Inhibitory Response ◽  
Growth Inhibitory

scholarly journals Gene expression signature of c-MYC-immortalized human fibroblasts reveals loss of growth inhibitory response to TGFβ

Cell Cycle ◽  
2011 ◽  
Vol 10 (15) ◽  
pp. 2540-2548 ◽  
Author(s):  
Myra L. Wang ◽  
Ryan Walsh ◽  
Kristin L. Robinson ◽  
Julja Burchard ◽  
Steven R. Bartz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Human Fibroblasts ◽  
Gene Expression Signature ◽  
Inhibitory Response ◽  
Expression Signature ◽  
Growth Inhibitory

Elevated Amounts of Protein in C6 Glial Cells During the Growth-Inhibitory Response Elicited by Dexamethasone

1981 ◽  
Vol 37 (2) ◽  
pp. 515-517 ◽  
Author(s):  
Robert J. Grasso ◽  
Nikki J. Holbrook ◽  
Steven F. Wodzinski
Keyword(s):  
Glial Cells ◽  
Inhibitory Response ◽  
Growth Inhibitory

scholarly journals EKSTRAK DAUN KATUK (Sauropus androgynus (L) Merr) SEBAGAI ANTIBAKTERI TERHADAP Propionibacterium acnes dan Staphylococcus epidermidis

2017 ◽  
Author(s):  
Yuli Wahyu Tri Mulyani ◽  
Dadan Hidayat ◽  
Isbiyantoro Isbiantoro ◽  
Yeni Fatimah
Keyword(s):  
Antibacterial Activity ◽  
Propionibacterium Acnes ◽  
Positive Control ◽  
Inhibitory Response ◽  
Negative Control ◽  
Diffusion Method ◽  
Zone Diameter ◽  
Growth Inhibitory ◽  
Weak Growth ◽  
Common Plant

Katuk is one of the most common plant species in Indonesia which is known by the community to treat the disease, especially the leaf part can be used as a milk mat. katuk leaf (Sauropus androgynus (L) Merr) also contains saponin, flavonoid and tannin Inhibits the growth of bacteria one of the bacteria that cause acne bacteria P. acnes and S. epidermidis. The aim of this research is to know the antibacterial inhibition effect of katuk leaf extract to growth of P. acnes and S. epidermidis using Cup-plate or pit diffusion method with concentration 20%, 40%, 60%, 80% and 100%. Clindamycin is used as a positive control and aquades as a negative control. The leaves of katuk extracted with 70% ethanol solvent showed no antibacterial activity against P. acnes bacteria while against S. epidermidis bacteria showed antibacterial activity. The highest antibacterial activity at 100% concentration with 18.17 mm zone diameter belong to the category of inhibitory resistance of medium growth and the lowest concentration at concentration of 40% with 16.68 mm inhibitory zone diameter belong to the weak growth inhibitory response category. The minimum inhibitory concentrations produced in S. epidermidis bacteria were 39% - 36%. Keywords : Sauropus androgynus, Propionibacterium acnes, Staphilococcus epidermidis, Minimal Inhibitory Concentration.

scholarly journals PRMT5: An Emerging Target for Pancreatic Adenocarcinoma

Cancers ◽  
2021 ◽  
Vol 13 (20) ◽  
pp. 5136
Author(s):  
Michael K. C. Lee ◽  
Sean M. Grimmond ◽  
Grant A. McArthur ◽  
Karen E. Sheppard
Keyword(s):  
Current Knowledge ◽  
Tumour Microenvironment ◽  
Inhibitory Response ◽  
Response To Therapy ◽  
Ductal Adenocarcinoma ◽  
Therapeutic Approaches ◽  
Growth Inhibitory ◽  
Increased Sensitivity ◽  
Novel Therapeutic ◽  
Significant Bearing

The overall survival of pancreatic ductal adenocarcinoma (PDAC) remains poor and its incidence is rising. Targetable mutations in PDAC are rare, thus novel therapeutic approaches are needed. Protein arginine methyltransferase 5 (PRMT5) overexpression is associated with worse survival and inhibition of PRMT5 results in decreased cancer growth across multiple cancers, including PDAC. Emerging evidence also suggests that altered RNA processing is a driver in PDAC tumorigenesis and creates a partial dependency on this process. PRMT5 inhibition induces altered splicing and this vulnerability can be exploited as a novel therapeutic approach. Three possible biological pathways underpinning the action of PRMT5 inhibitors are discussed; c-Myc regulation appears central to its action in the PDAC setting. Whilst homozygous MTAP deletion and symmetrical dimethylation levels are associated with increased sensitivity to PRMT5 inhibition, neither measure robustly predicts its growth inhibitory response. The immunomodulatory effect of PRMT5 inhibitors on the tumour microenvironment will also be discussed, based on emerging evidence that PDAC stroma has a significant bearing on disease behaviour and response to therapy. Lastly, with the above caveats in mind, current knowledge gaps and the implications and rationales for PRMT5 inhibitor development in PDAC will be explored.

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