Weight loss-induced cellular stress in subcutaneous adipose tissue and the risk for weight regain in overweight and obese adults

2016 ◽  
Vol 41 (6) ◽  
pp. 894-901 ◽  
Author(s):  
N J T Roumans ◽  
R G Vink ◽  
F G Bouwman ◽  
P Fazelzadeh ◽  
M A van Baak ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Weight Regain ◽  
Cellular Stress ◽  
Obese Adults ◽  
Subcutaneous Adipose

scholarly journals Weight loss-induced stress in subcutaneous adipose tissue is related to weight regain

2016 ◽  
Vol 115 (5) ◽  
pp. 913-920 ◽  
Author(s):  
Nadia J. T. Roumans ◽  
Stefan G. Camps ◽  
Johan Renes ◽  
Freek G. Bouwman ◽  
Klaas R. Westerterp ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Weight Regain ◽  
Stress Proteins ◽  
Dietary Intervention ◽  
Cellular Stress ◽  
Subcutaneous Adipose

AbstractInitial successful weight loss is often followed by weight regain after the dietary intervention. Compared with lean people, cellular stress in adipose tissue is increased in obese subjects. However, the relation between cellular stress and the risk for weight regain after weight loss is unclear. Therefore, we determined the expression levels of stress proteins during weight loss and weight maintenance in relation to weight regain. In vivo findings were compared with results from in vitro cultured human Simpson–Golabi–Behmel syndrome (SGBS) adipocytes. In total, eighteen healthy subjects underwent an 8-week diet programme with a 10-month follow-up. Participants were categorised as weight maintainers or weight regainers (WR) depending on their weight changes during the intervention. Abdominal subcutaneous adipose tissue biopsies were obtained before and after the diet and after the follow-up. In vitro differentiated SGBS adipocytes were starved for 96 h with low (0·55 mm) glucose. Levels of stress proteins were determined by Western blotting. WR showed increased expressions of β-actin, calnexin, heat shock protein (HSP) 27, HSP60 and HSP70. Changes of β-actin, HSP27 and HSP70 are linked to HSP60, a proposed key factor in weight regain after weight loss. SGBS adipocytes showed increased levels of β-actin and HSP60 after 96 h of glucose restriction. The increased level of cellular stress proteins in the adipose tissue of WR probably resides in the adipocytes as shown by in vitro experiments. Cellular stress accumulated in adipose tissue during weight loss may be a risk factor for weight regain.

721-P: Exercise Training Alters Subcutaneous Adipose Tissue Morphology in Obese Adults Even without Weight Loss

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 721-P
Author(s):  
CHIWOON AHN ◽  
BENJAMIN J. RYAN ◽  
JENNA B. GILLEN ◽  
ALISON LUDZKI ◽  
MICHAEL W. SCHLEH ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Exercise Training ◽  
Subcutaneous Adipose Tissue ◽  
Obese Adults ◽  
Tissue Morphology ◽  
Subcutaneous Adipose

Insulin resistance, systemic and regional inflammation in subcutaneous adipose tissue during weight loss in a population with obesity

2019 ◽  
Author(s):  
Frederique Van de Velde ◽  
Margriet Ouwens ◽  
Arsene-Helene Batens ◽  
Samyah Shadid ◽  
Bruno Lapauw ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Subcutaneous Adipose

701-P: Effects of Exercise on Extracellular Matrix Modifiers in Subcutaneous Adipose Tissue of Obese Adults

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 701-P
Author(s):  
PALLAVI VARSHNEY ◽  
BENJAMIN J. RYAN ◽  
CHIWOON AHN ◽  
MICHAEL W. SCHLEH ◽  
JEFFREY F. HOROWITZ
Keyword(s):  
Extracellular Matrix ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Obese Adults ◽  
Subcutaneous Adipose

Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue

2016 ◽  
Vol 12 (2) ◽  
pp. 257-263 ◽  
Author(s):  
Juan José González-Plaza ◽  
Carolina Gutiérrez-Repiso ◽  
Sara García-Serrano ◽  
Francisca Rodriguez-Pacheco ◽  
Lourdes Garrido-Sánchez ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Transcriptomic Profiling ◽  
Subcutaneous Adipose

scholarly journals Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss*

2000 ◽  
Vol 85 (9) ◽  
pp. 3338-3342 ◽  
Author(s):  
Jean-Philippe Bastard ◽  
Claude Jardel ◽  
Eric Bruckert ◽  
Patricia Blondy ◽  
Jacqueline Capeau ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Interleukin 6 ◽  
Subcutaneous Adipose Tissue ◽  
Obese Women ◽  
Subcutaneous Adipose
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