scholarly journals Heme oxygenase-1 gene promoter polymorphism and the risk of pediatric nonalcoholic fatty liver disease

2015 ◽  
Vol 39 (8) ◽  
pp. 1236-1240 ◽  
Author(s):  
P-F Chang ◽  
Y-C Lin ◽  
K Liu ◽  
S-J Yeh ◽  
Y-H Ni
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Heme Oxygenase ◽  
Fatty Liver Disease ◽  
Gene Promoter ◽  
Promoter Polymorphism ◽  
Heme Oxygenase 1 ◽  
Nonalcoholic Fatty Liver ◽  
Gene Promoter Polymorphism

scholarly journals Natural Product Heme Oxygenase Inducers as Treatment for Nonalcoholic Fatty Liver Disease

2020 ◽  
Vol 21 (24) ◽  
pp. 9493
Author(s):  
David E. Stec ◽  
Terry D. Hinds
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Dietary Supplements ◽  
Heme Oxygenase ◽  
Fatty Liver Disease ◽  
Defense Mechanism ◽  
Heme Oxygenase 1 ◽  
Lifestyle Modifications ◽  
Nonalcoholic Fatty Liver

Heme oxygenase (HO) is a critical component of the defense mechanism to a wide variety of cellular stressors. HO induction affords cellular protection through the breakdown of toxic heme into metabolites, helping preserve cellular integrity. Nonalcoholic fatty liver disease (NAFLD) is a pathological condition by which the liver accumulates fat. The incidence of NAFLD has reached all-time high levels driven primarily by the obesity epidemic. NALFD can progress to nonalcoholic steatohepatitis (NASH), advancing further to liver cirrhosis or cancer. NAFLD is also a contributing factor to cardiovascular and metabolic diseases. There are currently no drugs to specifically treat NAFLD, with most treatments focused on lifestyle modifications. One emerging area for NAFLD treatment is the use of dietary supplements such as curcumin, pomegranate seed oil, milk thistle oil, cold-pressed Nigella Satvia oil, and resveratrol, among others. Recent studies have demonstrated that several of these natural dietary supplements attenuate hepatic lipid accumulation and fibrosis in NAFLD animal models. The beneficial actions of several of these compounds are associated with the induction of heme oxygenase-1 (HO-1). Thus, targeting HO-1 through dietary-supplements may be a useful therapeutic for NAFLD either alone or with lifestyle modifications.

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