scholarly journals Impact of high-fat feeding on basic helix–loop–helix transcription factors controlling enteroendocrine cell differentiation

2014 ◽  
Vol 38 (11) ◽  
pp. 1440-1448 ◽  
Author(s):  
Y Sakar ◽  
F A Duca ◽  
B Langelier ◽  
F Devime ◽  
H Blottiere ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Cell Differentiation ◽  
High Fat ◽  
Enteroendocrine Cell ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix ◽  
Fat Feeding

scholarly journals A Classification of Basic Helix-Loop-Helix Transcription Factors of Soybean

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Karen A. Hudson ◽  
Matthew E. Hudson
Keyword(s):  
Transcription Factors ◽  
Genome Sequence ◽  
Search Algorithm ◽  
Soybean Genome ◽  
Binding Potential ◽  
Future Research ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix ◽  
Bhlh Genes ◽  
Wide Range

The complete genome sequence of soybean allows an unprecedented opportunity for the discovery of the genes controlling important traits. In particular, the potential functions of regulatory genes are a priority for analysis. The basic helix-loop-helix (bHLH) family of transcription factors is known to be involved in controlling a wide range of systems critical for crop adaptation and quality, including photosynthesis, light signalling, pigment biosynthesis, and seed pod development. Using a hidden Markov model search algorithm, 319 genes with basic helix-loop-helix transcription factor domains were identified within the soybean genome sequence. These were classified with respect to their predicted DNA binding potential, intron/exon structure, and the phylogeny of the bHLH domain. Evidence is presented that the vast majority (281) of these 319 soybean bHLH genes are expressed at the mRNA level. Of these soybean bHLH genes, 67% were found to exist in two or more homeologous copies. This dataset provides a framework for future studies on bHLH gene function in soybean. The challenge for future research remains to define functions for the bHLH factors encoded in the soybean genome, which may allow greater flexibility for genetic selection of growth and environmental adaptation in this widely grown crop.

A genome-wide survey on basic helix-loop-helix transcription factors in rat and mouse

2009 ◽  
Vol 20 (4) ◽  
pp. 236-246 ◽  
Author(s):  
X. Zheng ◽  
Y. Wang ◽  
Q. Yao ◽  
Z. Yang ◽  
K. Chen
Keyword(s):  
Transcription Factors ◽  
Basic Helix Loop Helix ◽  
Helix Loop Helix ◽  
Genome Wide ◽  
A Genome ◽  
Genome Wide Survey

Ebf1 controls early cell differentiation in the embryonic striatum

Development ◽  
1999 ◽  
Vol 126 (23) ◽  
pp. 5285-5294 ◽  
Author(s):  
S. Garel ◽  
F. Marin ◽  
R. Grosschedl ◽  
P. Charnay
Keyword(s):  
Transcription Factors ◽  
Cell Differentiation ◽  
Neuronal Differentiation ◽  
Regulatory Proteins ◽  
Targeted Disruption ◽  
Ventral Telencephalon ◽  
Molecular Identity ◽  
Helix Loop Helix ◽  
The Family ◽  
Mantle Cell

Ebf1/Olf-1 belongs to a small multigene family encoding closely related helix-loop-helix transcription factors, which have been proposed to play a role in neuronal differentiation. Here we show that Ebf1 controls cell differentiation in the murine embryonic striatum, where it is the only gene of the family to be expressed. Ebf1 targeted disruption affects postmitotic cells that leave the subventricular zone (SVZ) en route to the mantle: they appear to be unable to downregulate genes normally restricted to the SVZ or to activate some mantle-specific genes. These downstream genes encode a variety of regulatory proteins including transcription factors and proteins involved in retinoid signalling as well as adhesion/guidance molecules. These early defects in the SVZ/mantle transition are followed by an increase in cell death, a dramatic reduction in size of the postnatal striatum and defects in navigation and fasciculation of thalamocortical fibres travelling through the striatum. Our data therefore show that Ebf1 plays an essential role in the acquisition of mantle cell molecular identity in the developing striatum and provide information on the genetic hierarchies that govern neuronal differentiation in the ventral telencephalon.

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