scholarly journals Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice

2011 ◽  
Vol 35 (12) ◽  
pp. 1539-1548 ◽  
Author(s):  
K S Bell-Anderson ◽  
L Aouad ◽  
H Williams ◽  
F R Sanz ◽  
J Phuyal ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Liver Steatosis ◽  
Receptor Antagonism ◽  
Cannabinoid 1 Receptor

Loss of toll-like receptor 3 function improves glucose tolerance and reduces liver steatosis in obese mice

Metabolism ◽  
2012 ◽  
Vol 61 (11) ◽  
pp. 1633-1645 ◽  
Author(s):  
Linda H. Wu ◽  
C. Chris Huang ◽  
Sree Adhikarakunnathu ◽  
Lani R. San Mateo ◽  
Karen E. Duffy ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Liver Steatosis ◽  
Obese Mice ◽  
Toll Like Receptor

A combination of borage seed oil and quercetin reduces fat accumulation and improves insulin sensitivity in obese rats

2020 ◽  
Vol 11 (5) ◽  
pp. 4512-4524 ◽  
Author(s):  
Paula Aranaz ◽  
María Zabala ◽  
Ana Romo-Hualde ◽  
David Navarro-Herrera ◽  
Miguel López-Yoldi ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Seed Oil ◽  
Liver Steatosis ◽  
Key Factors ◽  
Fat Accumulation ◽  
Obese Rats

Borage seed oil (BSO) combined with quercetin improves glucose tolerance, insulin sensitivity, liver steatosis and adiposity in pre-obese rats. The combination also inhibits adipogenesis in vitro by affecting some adipogenesis-key factors.

scholarly journals Angiopoietin-like protein 4 improves glucose tolerance and insulin resistance but induces liver steatosis in high-fat-diet mice

2016 ◽  
Vol 14 (4) ◽  
pp. 3293-3300 ◽  
Author(s):  
Yi Wang ◽  
Li-Ming Liu ◽  
Li Wei ◽  
Wei-Wei Ye ◽  
Xiang-Ying Meng ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Tolerance ◽  
High Fat Diet ◽  
Liver Steatosis ◽  
High Fat

Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats

2010 ◽  
Vol 120 (2) ◽  
pp. 73-80 ◽  
Author(s):  
Bárbara Maiztegui ◽  
María I. Borelli ◽  
Viviana G. Madrid ◽  
Héctor Del Zotto ◽  
María A. Raschia ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Cell Function ◽  
Liver Steatosis ◽  
Cell Mass ◽  
Oral Glucose ◽  
Model Assessment ◽  
Metabolic Disturbances ◽  
Β Cell ◽  
Commercial Diet ◽  
Triacylglycerol Content

The aim of the present study was to test the effect of sitagliptin and exendin-4 upon metabolic alterations, β-cell mass decrease and hepatic steatosis induced by F (fructose) in rats. Normal adult male Wistar rats received a standard commercial diet without (C) or with 10% (w/v) F in the drinking water (F) for 3 weeks; animals from each group were randomly divided into three subgroups: untreated (C and F) and simultaneously receiving either sitagliptin (CS and FS; 115.2 mg/day per rat) or exendin-4 (CE and FE; 0.35 nmol/kg of body weight, intraperitoneally). Water and food intake, oral glucose tolerance, plasma glucose, triacylglycerol (triglyceride), insulin and fructosamine concentration, HOMA-IR [HOMA (homoeostasis model assessment) for insulin resistance], HOMA-β (HOMA for β-cell function) and liver triacylglycerol content were measured. Pancreas immunomorphometric analyses were also performed. IGT (impaired glucose tolerance), plasma triacylglycerol, fructosamine and insulin levels, HOMA-IR and HOMA-β indexes, and liver triacylglycerol content were significantly higher in F rats. Islet β-cell mass was significantly lower in these rats, due to an increase in the percentage of apoptosis. The administration of exendin-4 and sitagliptin to F animals prevented the development of all the metabolic disturbances and the changes in β-cell mass and fatty liver. Thus these compounds, useful in treating Type 2 diabetes, would also prevent/delay the progression of early metabolic and tissue markers of this disease.

β-Glycosphingolipids improve glucose intolerance and hepatic steatosis of the Cohen diabetic rat

2009 ◽  
Vol 296 (1) ◽  
pp. E72-E78 ◽  
Author(s):  
Ehud Zigmond ◽  
Sarah W. Zangen ◽  
Orit Pappo ◽  
Miriam Sklair-Levy ◽  
Gadi Lalazar ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Immune System ◽  
Glucose Tolerance ◽  
Immune Modulation ◽  
Cell Function ◽  
Liver Steatosis ◽  
Diabetic Rat ◽  
Oral Glucose ◽  
Dependent Manner ◽  
Mri Imaging

A link between altered levels of various gangliosides and the development of insulin resistance was described in transgenic mice. Naturally occurring glycosphingolipids were shown to exert immunomodulatory effects in a natural killer T (NKT) cell-dependent manner. This study examined whether glycosphingolipid-induced modulation of the immune system may reduce pancreatic and liver steatosis and stimulate insulin secretion in the Cohen diabetes-sensitive (CDS) rat, a lean model of non-insulin-resistant, nutritionally induced diabetes. Four groups of CDS rats fed a diabetogenic diet were treated with daily intraperitoneal injections of glycosphingolipids β-glucosylceramide, β-lactosylceramide, a combination of both (IGL), or vehicle (PBS) for up to 45 days. Immune modulation was assessed by fluorescence-activated cell sorting analysis of intrahepatic and intrasplenic lymphocytes. Steatosis was assessed by MRI imaging and histological examination of liver and pancreas, Blood glucose and plasma insulin concentrations were assessed during an oral glucose tolerance test. Administration of glycosphingolipids, particularly IGL, increased intrahepatic trapping of CD8 T and NKT lymphocytes. Pancreatic and liver histology were markedly improved and steatosis was reduced in all treated groups compared with vehicle-treated rats. Insulin secretion was restored after glycosphingolipid treatment, resulting in improved glucose tolerance. The immunomodulatory effect of β-glycosphingolipids improved the β-cell function of the hyperglycemic CDS rat. Thus our results suggest a role for the immune system in the pathogenesis of diabetes in this model.

The liver-selective NO donor, V-PYRRO/NO, protects against liver steatosis and improves postprandial glucose tolerance in mice fed high fat diet

2015 ◽  
Vol 93 (3) ◽  
pp. 389-400 ◽  
Author(s):  
Edyta Maslak ◽  
Piotr Zabielski ◽  
Kamila Kochan ◽  
Kamil Kus ◽  
Agnieszka Jasztal ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
High Fat Diet ◽  
Liver Steatosis ◽  
Postprandial Glucose ◽  
High Fat ◽  
No Donor

Obstructive Sleep Apnoea, Glucose Tolerance and Liver Steatosis in Obese Women

2007 ◽  
Vol 35 (4) ◽  
pp. 458-466 ◽  
Author(s):  
G Acartürk ◽  
M Ünlü ◽  
S Yüksel ◽  
R Albayrak ◽  
T Köken ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Obstructive Sleep Apnoea ◽  
Liver Steatosis ◽  
Multivariate Logistic Regression Analysis ◽  
Sleep Apnoea ◽  
Oral Glucose ◽  
Obese Women ◽  
Abdominal Ultrasonography ◽  
Obstructive Sleep ◽  
Grade Iii

In this study of obstructive sleep apnoea (OSA), glucose tolerance and liver steatosis in females from an obesity unit, 45 patients (mean age 46.8 years, mean body mass index 39.4 kg/m2, all non-diabetic and alcohol abstainers) underwent nocturnal polysomnography, a 2 h oral glucose tolerance test and abdominal ultrasonography. OSA, defined as an apnoea–hypopnoea index (AHI) of ≤ 10 events/h, was present in 20 patients (44%). Impaired glucose tolerance (IGT) was found in eight patients (40%) with OSA and three patients (12%) without OSA; there was a positive linear relationship between AHI and post-load glucose levels. On multivariate logistic regression analysis, IGT was predicted by OSA independently of age, waist circumference, systolic blood pressure and current smoking. Liver steatosis was present in 37 women (82.2%), of whom six had grade III steatosis. Of the variables tested, IGT was the only predictor of grade III steatosis. In conclusion, OSA is an independent predictor of IGT which, in turn, is associated with severe liver steatosis in an obesity unit-based sample of women.

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