scholarly journals Genetic variants near the MGAT1 gene are associated with body weight, BMI and fatty acid metabolism among adults and children

2011 ◽  
Vol 36 (1) ◽  
pp. 119-129 ◽  
Author(s):  
J A Jacobsson ◽  
M Rask-Andersen ◽  
U Risérus ◽  
G Moschonis ◽  
A Koumpitski ◽  
...  
Keyword(s):  
Body Weight ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Genetic Variants ◽  
Acid Metabolism ◽  
Adults And Children

scholarly journals Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight

2008 ◽  
Vol 105 (4) ◽  
pp. 1550-1559 ◽  
Author(s):  
Michael J. Wolfgang ◽  
Seung Hun Cha ◽  
David S. Millington ◽  
Gary Cline ◽  
Gerald I. Shulman ◽  
...  
Keyword(s):  
Body Weight ◽  
Fatty Acid ◽  
Food Intake ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Carnitine Palmitoyl Transferase

scholarly journals The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans

BMC Genetics ◽  
2011 ◽  
Vol 12 (1) ◽  
pp. 50 ◽  
Author(s):  
Rasika A Mathias ◽  
Susan Sergeant ◽  
Ingo Ruczinski ◽  
Dara G Torgerson ◽  
Christina E Hugenschmidt ◽  
...  
Keyword(s):  
Fatty Acid ◽  
African Americans ◽  
Polyunsaturated Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Genetic Variants ◽  
Acid Metabolism ◽  
The Impact

scholarly journals Intake of red and processed meat, use of non-steroid anti-inflammatory drugs, genetic variants and risk of colorectal cancer; a prospective study of the Danish “Diet, Cancer and Health” cohort

2018 ◽  
Author(s):  
Vibeke Andersen ◽  
Ulrich Halekoh ◽  
Anne Tjønneland ◽  
Ulla Vogel ◽  
Tine Iskov Kopp
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Genetic Variants ◽  
Acid Metabolism ◽  
Processed Meat ◽  
Gene Variants ◽  
Meat Intake ◽  
Inflammatory Drugs ◽  
Red And Processed Meat

Red and processed meat have been associated with increased risk of colorectal cancer (CRC), whereas long-term use of non-steroid anti-inflammatory drugs (NSAIDs) may reduce the risk. The aim was to investigate potential interactions between meat intake, NSAID use, and gene variants in fatty acid metabolism and NSAID pathways in relation to the risk of CRC. A nested case-cohort study of 1038 CRC cases and 1857 randomly selected participants from the Danish prospective “Diet, Cancer and Health” study encompassing 57,053 persons was performed using the Cox proportional hazard models. Gene variants in SLC25A20, PRKAB1, LPCAT1, PLA2G4A, ALOX5, PTGER3, TP53, CCAT2, TCF7L2, BCL2 were investigated. CCAT2 rs6983267 was associated with risk of CRC per se (p<0.01). Statistically significant interactions were found between intake of red and processed meat and CCAT2 rs6983267, TP53 rs1042522, LPCAT1 rs7737692, SLC25A20 rs7623023 (pinteraction=0.04, 0.04, 0.02, 0.03, respectively), and use of NSAID and alcohol intake and TP53 rs1042522 (pinteraction=0.04, 0.04, respectively) in relation to risk of CRC. No other consistent associations or interactions were found. This study replicated an association of CCAT2 rs6983267 with CRC and an interaction between TP53 rs1042522 and NSAID in relation to CRC. Interactions between genetic variants in fatty acid metabolism and NSAID pathway and intake of red and processed meat were found. Our results suggest that meat intake and NSAID use affect the same carcinogenic mechanisms. All new findings should be sought replicated in independent prospective studies. Future studies on the cancer-protective effects of aspirin/NSAID should include gene and meat assessments.

scholarly journals Intake of Red and Processed Meat, Use of Non-Steroid Anti-Inflammatory Drugs, Genetic Variants and Risk of Colorectal Cancer: A Prospective Study of the Danish “Diet, Cancer and Health” Cohort

2019 ◽  
Vol 20 (5) ◽  
pp. 1121 ◽  
Author(s):  
Vibeke Andersen ◽  
Ulrich Halekoh ◽  
Anne Tjønneland ◽  
Ulla Vogel ◽  
Tine Kopp
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Genetic Variants ◽  
Acid Metabolism ◽  
Processed Meat ◽  
Gene Variants ◽  
Meat Intake ◽  
Inflammatory Drugs ◽  
Red And Processed Meat

Red and processed meat have been associated with increased risk of colorectal cancer (CRC), whereas long-term use of non-steroid anti-inflammatory drugs (NSAIDs) may reduce the risk. The aim was to investigate potential interactions between meat intake, NSAID use, and gene variants in fatty acid metabolism and NSAID pathways in relation to the risk of CRC. A nested case-cohort study of 1038 CRC cases and 1857 randomly selected participants from the Danish prospective “Diet, Cancer and Health” study encompassing 57,053 persons was performed using the Cox proportional hazard model. Gene variants in SLC25A20, PRKAB1, LPCAT1, PLA2G4A, ALOX5, PTGER3, TP53, CCAT2, TCF7L2, and BCL2 were investigated. CCAT2 rs6983267 was associated with the risk of CRC per se (p < 0.01). Statistically significant interactions were found between intake of red and processed meat and CCAT2 rs6983267, TP53 rs1042522, LPCAT1 rs7737692, SLC25A20 rs7623023 (pinteraction = 0.04, 0.04, 0.02, 0.03, respectively), and the use of NSAID and alcohol intake and TP53 rs1042522 (pinteraction = 0.04, 0.04, respectively) in relation to the risk of CRC. No other consistent associations or interactions were found. This study replicated an association of CCAT2 rs6983267 with CRC and an interaction between TP53 rs1042522 and NSAID in relation to CRC. Interactions between genetic variants in fatty acid metabolism and NSAID pathways and the intake of red and processed meat were found. Our results suggest that meat intake and NSAID use affect the same carcinogenic mechanisms. All new findings should be sought replicated in independent prospective studies. Future studies on the cancer-protective effects of aspirin/NSAID should include gene and meat assessments.

scholarly journals Efficacy of Novavit in ameliorating the neurotoxicity of propionic acid

2020 ◽  
Vol 11 (1) ◽  
pp. 134-146
Author(s):  
Sarah I. Bukhari ◽  
Hanan Alfawaz ◽  
Abeer Al-Dbass ◽  
Ramesa Shafi Bhat ◽  
Nadine MS Moubayed ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Fatty Acid ◽  
Gut Microbiota ◽  
Propionic Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Albino Rats ◽  
Oral Supplementation ◽  
Impaired Fatty Acid

AbstractOxidative stress, abnormal fatty acid metabolism, and impaired gut microbiota play a serious role in the pathology of autism. The use of dietary supplements to improve the core symptoms of autism is a common therapeutic strategy. The present study analyzed the effects of oral supplementation with Novavit, a multi-ingredient supplement, on ameliorating oxidative stress and impaired lipid metabolism in a propionic acid (PPA)-induced rodent model of autism. Male western albino rats were divided into three groups. The first group is the control, the second group was given an oral neurotoxic dose of PPA (250 mg/kg body weight/day) for 3 days and then received buffered saline until the end of the experiment. The third group received Novavit (70 mg/kg body weight/day for 30 days after the 3-day PPA treatment). Markers of oxidative stress and impaired fatty acid metabolism were measured in brain homogenates obtained from each group. Novavit modulation of the gut microbiota was also evaluated. While PPA induced significant increases in lipid peroxides and 5-lipoxygenase, together with significantly decreased glutathione, and cyclooxygenase 2, oral supplementation with Novavit ameliorated PPA-induced oxidative stress and impaired fatty acid metabolism. Our results showed that the presence of multivitamins, coenzyme Q10, minerals, and colostrum, the major components of Novavit, protects against PPA-induced neurotoxicity.

The Influence of Lactate and Dipyridamole on Myocardial Fatty Acid Metabolism in Man, Traced with 123l-17-lodo-heptadecanoic Acid

1990 ◽  
Vol 29 (01) ◽  
pp. 28-34 ◽  
Author(s):  
F. C. Visser ◽  
M. J. van Eenige ◽  
G. Westera ◽  
J. P. Roos ◽  
C. M. B. Duwel
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Time Activity ◽  
Time Value ◽  
Myocardial Fatty Acid Metabolism ◽  
Coronary Vasodilatation ◽  
Activity Curve ◽  
Normal Human ◽  
Plasma Lactate Level

Changes in myocardial metabolism can be detected externally by registration of time-activity curves after administration of radioiodinated fatty acids. In this scintigraphic study the influence of lactate on fatty acid metabolism was investigated in the normal human myocardium, traced with 123l-17-iodoheptadecanoic acid (123l-17-HDA). In patients (paired, n = 7) lactate loading decreased the uptake of 123l-17-HDA significantly from 27 (control: 22-36) to 20 counts/min/pixel (16-31; p <0.05 Wilcoxon). The half-time value increased to more than 60 rriin (n = 5), oxidation decreased from 61 to 42%. Coronary vasodilatation, a well-known side effect of lactate loading, was studied separately in a dipyridamole study (paired, n = 6). Coronary vasodilatation did not influence the parameters of the time-activity curve. These results suggest that changes in plasma lactate level as occurring, among other effects, during exercise will influence the parameters of dynamic 123l-17-HDA scintigraphy of the heart.

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