Ejaculatory training lengthens the ejaculation latency and facilitates the functioning of the spinal generator for ejaculation of rats with rapid ejaculation

2016 ◽  
Vol 29 (1) ◽  
pp. 35-42 ◽  
Author(s):  
M de L Rodríguez-Peña ◽  
G Rodríguez-Manzo ◽  
M Carro-Juárez
Keyword(s):  
Ejaculation Latency ◽  
Spinal Generator

3-30-05 A case of segmental myoclonus in amputation stump: Evidence for spinal generator

1997 ◽  
Vol 150 ◽  
pp. S180
Author(s):  
F. Devetag ◽  
G. Caneve ◽  
F. Malfa ◽  
G. Mandich ◽  
G. Zaiotti
Keyword(s):  
Amputation Stump ◽  
Spinal Generator

Is there a spinal generator of central pain?

2012 ◽  
pp. 289-301
Author(s):  
Sergio Canavero ◽  
Vincenzo Bonicalzi
Keyword(s):  
Central Pain ◽  
Spinal Generator

scholarly journals Discontinuation of Dapoxetine Treatment in Patients with Premature Ejaculation: A 2-Year Prospective Observational Study

2016 ◽  
Vol 9 (1) ◽  
pp. 66-66
Author(s):  
H. Park ◽  
◽  
N. Park ◽  
Keyword(s):  
Side Effects ◽  
Prospective Observational Study ◽  
Premature Ejaculation ◽  
Treatment Options ◽  
Drop Out ◽  
Discontinuation Rate ◽  
Oral Agent ◽  
Pde5 Inhibitors ◽  
Ejaculation Latency ◽  
Intravaginal Ejaculation Latency Time

Objective: Although dapoxetine is the only oral agent approved for premature ejaculation (PE) and is very effective, its discontinuation rate is high compared to PDE5 inhibitors for ED treatment. We assessed discontinuation rate of dapoxetine in PE and the reasons for discontinuation. Design and Method: The study enrolled 182 patients (mean age 38.2). The PE type (life-long or acquired), self-estimated intravaginal ejaculation latency time (IELT), IIEF-EF questionnaire, and medical history were checked in all patients. The patients were evaluated 1, 3, 6, 12, and 24 months after initiating therapy regarding the treatment status and the reasons for treatment discontinuation. Results: Of the patients, 9.9% were still in treatment after 2 years. The discontinuation rates at 1, 3, 6, 12, and 24 months were 26.4, 35.2, 17.6, 8.2, and 2.7%, respectively. Cumulatively, 79.1% of the patients discontinued the treatment within 6 months. After 12 months, however, the discontinuation rate dropped sharply. The reasons for discontinuation were cost (29.9%), disappointment that PE is not a curable disease and dapoxetine was needed whenever he had sex (25%), side effects (11.6%), low efficacy (9.8%), to seek other treatment options (5.5%), and unknown (18.3%). Patients with acquired PE (vs. life-long), IELT >2 min before treatment, older than 50 years, taking PDE-5 inhibitors, and IIEF-EF <26 tended to discontinue early and had high drop-out rates. Conclusions: Only 9.9% patients continued treatment after 24 months, while 79.1% discontinued within 6 months. The main reasons for discontinuation were not related to its side effects or low efficacy.

2040 A SYSTEMATIC REVIEW AND META-ANALYSIS OF ANEJACULATION IN SPINAL CORD INJURED PATIENTS IN FAVOUR OF A SPINAL GENERATOR OF EJACULATION

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Clément Chéhensse ◽  
Stéphane Bahrami ◽  
Pierre Denys ◽  
Pierre Clément ◽  
François Giuliano
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Meta Analysis ◽  
Spinal Generator ◽  
Injured Patients ◽  
Spinal Cord Injured

Endogenous opioids are differentially involved in appetitive and consummatory aspects of sexual behavior of male rats

1994 ◽  
Vol 266 (2) ◽  
pp. R606-R613 ◽  
Author(s):  
W. R. Van Furth ◽  
I. G. Wolterink-Donselaar ◽  
J. M. van Ree
Keyword(s):  
Sexual Behavior ◽  
Neural Control ◽  
Test Chamber ◽  
Endogenous Opioids ◽  
Male Rats ◽  
Opioid Antagonist ◽  
Sexual Performance ◽  
Repeated Testing ◽  
Ejaculation Latency ◽  
Male Wistar Rats

The sexual activity of 40 male Wistar rats was tested weekly in a bilevel test chamber to evaluate the involvement of endogenous opioids in the appetitive and consummatory aspects of sexual behavior. It has been suggested that the increase of the anticipatory level-changing behavior over repeated testing, displayed before the introduction of a receptive female, is sexually motivated. Two doses of the opioid antagonist naloxone, 1 and 10 mg/kg, prevented the increase of the anticipatory level-changing over four repeated tests of sexually experienced rats without prior experience in the bilevel test chamber and decreased the number of level changes of rats displaying a high number of level changes. Analysis of the pattern of inhibition suggested that the lower dose of naloxone may reduce sexual reward and that, in addition, the higher dose may block the expression of motivation. In contrast, naloxone treatment facilitated the efficiency of the sexual performance, with less mounts and intromissions preceding ejaculation and a shorter ejaculation latency, implying an inhibitory role of endogenous opioids in the neural control of some aspects of sexual performance (e.g., ejaculatory threshold). These results suggest that endogenous opioids may increase sexual appetite and diminish sexual performance.

scholarly journals Astrocytes in the medial preoptic area modulate ejaculation latency in an experience-dependent fashion.

2015 ◽  
Vol 129 (1) ◽  
pp. 68-73 ◽  
Author(s):  
Ryan G. Will ◽  
Victoria L. Nutsch ◽  
Jonathan M. Turner ◽  
Tomoko Hattori ◽  
Daniel J. Tobiansky ◽  
...  
Keyword(s):  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Ejaculation Latency
Sign in / Sign up

Export Citation Format

Share Document