scholarly journals Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

2008 ◽  
Vol 20 (3) ◽  
pp. 315-323 ◽  
Author(s):  
R A Hill ◽  
E R Simpson ◽  
W C Boon
Keyword(s):  
Mouse Strain ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Sexually Dimorphic

scholarly journals Medial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Yi-Chao Wei ◽  
Shao-Ran Wang ◽  
Zhuo-Lei Jiao ◽  
Wen Zhang ◽  
Jun-Kai Lin ◽  
...  
Keyword(s):  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Sexually Dimorphic

scholarly journals The Volume of a Sexually Dimorphic Nucleus in the Ovine Medial Preoptic Area/Anterior Hypothalamus Varies with Sexual Partner Preference

Endocrinology ◽  
2004 ◽  
Vol 145 (2) ◽  
pp. 478-483 ◽  
Author(s):  
Charles E. Roselli ◽  
Kay Larkin ◽  
John A. Resko ◽  
John N. Stellflug ◽  
Fred Stormshak
Keyword(s):  
Sexual Partner ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Anterior Hypothalamus ◽  
Cell Group ◽  
Sexually Dimorphic ◽  
Mrna Levels ◽  
Sexual Preferences ◽  
Estrogen Synthesis ◽  
Sexually Dimorphic Nucleus

Abstract Sheep are one of the few animal models in which natural variations in male sexual preferences have been studied experimentally. Approximately 8% of rams exhibit sexual preferences for male partners (male-oriented rams) in contrast to most rams, which prefer female partners (female-oriented rams). We identified a cell group within the medial preoptic area/anterior hypothalamus of age-matched adult sheep that was significantly larger in adult rams than in ewes. This cell group was labeled the ovine sexually dimorphic nucleus (oSDN). In addition to a sex difference, we found that the volume of the oSDN was two times greater in female-oriented rams than in male-oriented rams. The dense cluster of neurons that comprise the oSDN express cytochrome P450 aromatase. Aromatase mRNA levels in the oSDN were significantly greater in female-oriented rams than in ewes, whereas male-oriented rams exhibited intermediate levels of expression. Because the medial preoptic area/anterior hypothalamus is known to control the expression of male sexual behaviors, these results suggest that naturally occurring variations in sexual partner preferences may be related to differences in brain anatomy and capacity for estrogen synthesis.

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