Competition within the virus‐specific CD4 T‐cell pool limits the T follicular helper response after influenza infection

2016 ◽  
Vol 94 (8) ◽  
pp. 729-740 ◽  
Author(s):  
Matthew R Olson ◽  
Brendon Y Chua ◽  
Kim L Good‐Jacobson ◽  
Peter C Doherty ◽  
David C Jackson ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza Infection ◽  
Cd4 T Cell ◽  
Follicular Helper ◽  
Cell Pool ◽  
Helper Response

No evidence for proliferation in the blood CD4+ T-cell pool during HIV-1 infection and triple combination therapy

AIDS ◽  
1998 ◽  
Vol 12 (8) ◽  
pp. 879-884 ◽  
Author(s):  
Olivier Tissot ◽  
Jean-Paul Viard ◽  
Cécile Rabian ◽  
Nicole Ngo ◽  
Marianne Burgard ◽  
...  
Keyword(s):  
T Cell ◽  
Combination Therapy ◽  
Cd4 T Cell ◽  
Triple Combination ◽  
Triple Combination Therapy ◽  
Cell Pool ◽  
Hiv 1

scholarly journals CD25-Targeted IL-2 Signals Promote Improved Outcomes of Influenza Infection and Boost Memory CD4 T Cell Formation

2020 ◽  
Vol 204 (12) ◽  
pp. 3307-3314
Author(s):  
Fahmida Alam ◽  
Ayushi Singh ◽  
Valeria Flores-Malavet ◽  
Stewart Sell ◽  
Andrea M. Cooper ◽  
...  
Keyword(s):  
T Cell ◽  
Influenza Infection ◽  
Cell Formation ◽  
Cd4 T Cell ◽  
Improved Outcomes

scholarly journals Murine CD4+ T cell clones vary in function in vitro and in influenza infection in vivo

1990 ◽  
Vol 2 (4) ◽  
pp. 323-328 ◽  
Author(s):  
Patricia M. Taylor ◽  
Fernando Esquivel ◽  
Brigitte A. Askonas
Keyword(s):  
T Cell ◽  
Influenza Infection ◽  
Cd4 T Cell ◽  
T Cell Clones ◽  
Cell Clones

scholarly journals Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation

2005 ◽  
Vol 202 (5) ◽  
pp. 697-706 ◽  
Author(s):  
Dawn M. Jelley-Gibbs ◽  
Deborah M. Brown ◽  
John P. Dibble ◽  
Laura Haynes ◽  
Sheri M. Eaton ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
High Efficiency ◽  
Influenza Infection ◽  
Cd4 T Cell ◽  
Intermediate Phenotypes ◽  
Donor T Cells ◽  
T Cell Transfer ◽  
Kinetics Of

The kinetics of presentation of influenza virus–derived antigens (Ags), resulting in CD4 T cell effector and memory generation, remains undefined. Naive influenza-specific CD4 T cells were transferred into mice at various times after influenza infection to determine the duration and impact of virus-derived Ag presentation. Ag-specific T cell responses were generated even when the donor T cells were transferred 3–4 wk after viral clearance. Transfer of naive CD4 T cells during early phases of infection resulted in a robust expansion of highly differentiated effectors, which then contracted to a small number of memory T cells. Importantly, T cell transfer during later phases of infection resulted in a modest expansion of effectors with intermediate phenotypes, which were capable of persisting as memory with high efficiency. Thus, distinct stages of pathogen-derived Ag presentation may provide a mechanism by which T cell heterogeneity is generated and diverse memory subsets are maintained.

110. Effects of social disruption stress on CD4+ T cell activation, trafficking, and survival during influenza infection

2008 ◽  
Vol 22 (4) ◽  
pp. 35
Author(s):  
LaTonia Stiner-Jones ◽  
Mark Hanke ◽  
Nicole Powell ◽  
David Padgett ◽  
John Sheridan
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Influenza Infection ◽  
Cd4 T Cell ◽  
Social Disruption

scholarly journals Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo

2012 ◽  
Vol 109 (42) ◽  
pp. 16992-16997 ◽  
Author(s):  
C. Iwamura ◽  
K. Shinoda ◽  
Y. Endo ◽  
Y. Watanabe ◽  
D. J. Tumes ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Natural Killer ◽  
Natural Killer T Cells ◽  
Pool Size ◽  
Cd4 T Cell ◽  
Cell Pool ◽  
And Function ◽  
Killer T Cells

scholarly journals CD4 T Cell-Independent Antibody Response Promotes Resolution of Primary Influenza Infection and Helps to Prevent Reinfection

2005 ◽  
Vol 175 (9) ◽  
pp. 5827-5838 ◽  
Author(s):  
Byung O. Lee ◽  
Javier Rangel-Moreno ◽  
Juan E. Moyron-Quiroz ◽  
Louise Hartson ◽  
Melissa Makris ◽  
...  
Keyword(s):  
T Cell ◽  
Antibody Response ◽  
Influenza Infection ◽  
Cd4 T Cell
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