Hepatitis B virus X protein modulates renal tubular epithelial cell‐induced T‐cell and macrophage responses

2015 ◽  
Vol 94 (3) ◽  
pp. 266-273 ◽  
Author(s):  
Xuan Wang ◽  
Ling Wang ◽  
Nan Zhu ◽  
Yi Zhou ◽  
Li‐jie Gu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Epithelial Cell ◽  
Hepatitis B ◽  
Tubular Epithelial Cell ◽  
Renal Tubular Epithelial Cell ◽  
X Protein ◽  
B Virus ◽  
Renal Tubular

Effects of hepatitis B virus X protein on human T cell cytokines

2013 ◽  
Vol 59 (9) ◽  
pp. 620-626 ◽  
Author(s):  
XiaoLi Lou ◽  
YanQiang Hou ◽  
DongYu Liang
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Inflammatory Cytokine ◽  
Jurkat Cells ◽  
Cytokine Secretion ◽  
X Protein ◽  
Human T Cell ◽  
Tnf Α ◽  
B Virus

Chronic infection with hepatitis B virus (HBV) plays a significant role in hepatocellular carcinoma development. To investigate the effect of hepatitis B virus X protein (HBx) on inflammatory cytokines of human T cell, a eukaryotic expression vector, HBx-pEGFP-C1, was constructed and transfected into the Jurkat human T-cell line. Jurkat cells were transfected transiently using Lipofectamine 2000 and activated by phytohemagglutinin (PHA). Interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), IL-4, IL-10, IL-13, and IL-14 mRNA was measured. The results showed that the vector HBx-pEGFP-C1 was successfully constructed, and HBx was expressed in Jurkat cells. Compared with a control group, mRNA of IL-1β and TNF-α was significantly elevated in the HBx-pEGFP-C1 group (p < 0.05), while IL-4, IL-10, IL-13, and IL-14 mRNA was decreased (p < 0.05). Therefore, transient overexpression of HBx promoted PHA-induced pro-inflammatory cytokine secretion and repressed anti-inflammatory cytokine secretion in human T cells.

scholarly journals Expression of Hepatitis B Virus X Protein in Hepatocytes Suppresses CD8+T Cell Activity

2010 ◽  
Vol 10 (4) ◽  
pp. 126 ◽  
Author(s):  
Mi Jin Lee ◽  
Young-hee Jin ◽  
Kyongmin Kim ◽  
Yangkyu Choi ◽  
Hyoung-Chin Kim ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Cell Activity ◽  
Cd8 T Cell ◽  
X Protein ◽  
B Virus

scholarly journals HIV-1 harboring renal tubular epithelial cell interaction with T cells results in T cell trans-infection

Virology ◽  
2009 ◽  
Vol 385 (1) ◽  
pp. 105-114 ◽  
Author(s):  
Joanna Mikulak ◽  
Saul Teichberg ◽  
Thomas Faust ◽  
Helena Schmidtmayerova ◽  
Pravin C. Singhal
Keyword(s):  
T Cells ◽  
T Cell ◽  
Epithelial Cell ◽  
Cell Interaction ◽  
Tubular Epithelial Cell ◽  
Renal Tubular Epithelial Cell ◽  
Trans Infection ◽  
Renal Tubular ◽  
Hiv 1

scholarly journals The Hepatitis B Virus X Protein Induces HIV-1 Replication and Transcription in Synergy with T-cell Activation Signals

2001 ◽  
Vol 276 (38) ◽  
pp. 35435-35443 ◽  
Author(s):  
Marta Gómez-Gonzalo ◽  
Marta Carretero ◽  
Joaquı́n Rullas ◽  
Enrique Lara-Pezzi ◽  
José Aramburu ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
T Cell Activation ◽  
Cell Activation ◽  
X Protein ◽  
B Virus ◽  
Hiv 1

How Far we are towards Eradication of HBV Infection

2015 ◽  
Vol 24 (4) ◽  
pp. 473-479 ◽  
Author(s):  
Mihai Voiculescu
Keyword(s):  
Immune Response ◽  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
T Cell Receptors ◽  
Hepatitis B Surface Antigen ◽  
Hbv Infection ◽  
Major Health Problem ◽  
Cell Receptors ◽  
B Virus

Hepatitis B virus (HBV) infection is a major health problem with an important biological and a significant socio-economic impact all over the world. There is a high pressure to come up with a new and more efficient strategy against HBV infection, especially after the recent success of HCV treatment. Preventing HBV infection through vaccine is currently the most efficient way to decrease HBV-related cirrhosis and liver cancer incidence, as well as the best way to suppress the HBV reservoir. The vaccine is safe and efficient in 80-95% of cases. One of its most important roles is to reduce materno-fetal transmission, by giving the first dose of vaccine in the first 24 hours after birth. Transmission of HBV infection early in life is still frequent, especially in countries with high endemicity.Successful HBV clearance by the host is immune-mediated, with a complex combined innate and adaptive cellular and humoral immune response. Different factors, such as the quantity and the sequence of HBV epitope during processing by dendritic cells and presenting by different HLA molecules or the polymorphism of T cell receptors (TOL) are part of a complex network which influences the final response. A new potential therapeutic strategy is to restore T-cell antiviral function and to improve innate and adaptive immune response by immunotherapeutic manipulation.It appears that HBV eradication is far from being completed in the next decades, and a new strategy against HBV infection must be considered. Abbreviations: ALT: alanine aminotransferase; APC: antigen presenting cells; cccDNA: covalently closed circular DNA; HBIG: hepatitis B immunoglobulin; HbsAg: hepatitis B surface antigen; HBV: hepatitis B virus; HCC: hepatocellular carcinoma; CTL: cytotoxic T lymphocyte; IFN: interferon; NUC: nucleos(t)ide analogues; pg RNA: pre genomic RNA; TLR: toll-like receptors; TOL: T cell receptors.

A Case of Fulminant Hepatitis B Induced by Chemotherapy for Adult T-cell Leukemia in Hepatitis B Virus Carrier

2004 ◽  
Vol 66 (1) ◽  
pp. 19-22
Author(s):  
Nobuaki CHOSA ◽  
Hitoshi MIYAGUNI ◽  
Shinichiro TSUMORI ◽  
Katsumi OGATA ◽  
Mitsuru SETOYAMA
Keyword(s):  
Hepatitis B Virus ◽  
T Cell ◽  
Hepatitis B ◽  
Fulminant Hepatitis ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
B Virus ◽  
Hepatitis B Virus Carrier ◽  
Virus Carrier
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