Lethal giant larvae‐1 deficiency enhances the CD8 + effector T‐cell response to antigen challenge in vivo

2015 ◽  
Vol 94 (3) ◽  
pp. 306-311 ◽  
Author(s):  
Kelly M Ramsbottom ◽  
Faruk Sacirbegovic ◽  
Edwin D Hawkins ◽  
Axel Kallies ◽  
Gabrielle T Belz ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Antigen Challenge ◽  
Effector T Cell ◽  
Lethal Giant Larvae

scholarly journals Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide.

1990 ◽  
Vol 171 (5) ◽  
pp. 1815-1820 ◽  
Author(s):  
P Aichele ◽  
H Hengartner ◽  
R M Zinkernagel ◽  
M Schulz
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Lymphocytic Choriomeningitis ◽  
Effector T Cells ◽  
T Cell Response ◽  
Class I ◽  
Cytotoxic T Cell ◽  
Effector T Cell

Induction in vivo of antiviral cytotoxic T cell response was achieved in a MHC class I-dependent fashion by immunizing mice three times with a free unmodified 15-mer peptide derived from the nucleoprotein of lymphocytic choriomeningitis virus in IFA. The effector T cells are CD8+, restricted to the class I Ld allele of the analyzed mouse strain, and are specific both at the level of secondary restimulation in vitro and at the effector T cell level. These results suggest that cocktails of viral peptides may be used as antiviral T cell vaccines.

scholarly journals Vigorous Premalignancy-specific Effector T Cell Response in the Bone Marrow of Patients with Monoclonal Gammopathy

2003 ◽  
Vol 198 (11) ◽  
pp. 1753-1757 ◽  
Author(s):  
Madhav V. Dhodapkar ◽  
Joseph Krasovsky ◽  
Keren Osman ◽  
Matthew D. Geller
Keyword(s):  
T Cells ◽  
Immune System ◽  
T Cell ◽  
Cell Response ◽  
Direct Evidence ◽  
Human Cancer ◽  
T Cell Response ◽  
Immune Recognition ◽  
Effector T Cell ◽  
Specific Effector

Most approaches targeting the immune system against tumors have focused on patients with established tumors. However, whether the immune system can recognize preneoplastic stages of human cancer is not known. Here we show that patients with preneoplastic gammopathy mount a vigorous T cell response to autologous premalignant cells. This preneoplasia-specific CD4+ and CD8+ T cell response is detected in freshly isolated T cells from the BM. T cells from myeloma marrow lack this tumor-specific rapid effector function. These data provide direct evidence for tumor specific immune recognition in human preneoplasia and suggest a possible role for the immune system in influencing the early growth of transformed cells, long before the development of clinical cancer.

scholarly journals A Switch in Costimulation from CD28 to 4-1BB during Primary versus Secondary CD8 T Cell Response to Influenza In Vivo

2004 ◽  
Vol 172 (2) ◽  
pp. 981-988 ◽  
Author(s):  
Edward M. Bertram ◽  
Wojciech Dawicki ◽  
Bradley Sedgmen ◽  
Jonathan L. Bramson ◽  
David H. Lynch ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response

scholarly journals PD-L1hi plasmablasts limit the T cell response during the acute phase of parasite infections

2020 ◽  
Author(s):  
Melisa Gorosito Serrán ◽  
Facundo Fiocca Vernengo ◽  
Laura Almada ◽  
Cristian G Beccaria ◽  
Pablo F Canete ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Cell Activation ◽  
Mononuclear Cells ◽  
Plasma Cells ◽  
Chronic Phase ◽  
Surface Expression ◽  
T Cell Response

ABSTRACTDuring infections with protozoan parasites or virus, T cell immunosuppression is generated simultaneously with a high B cell activation. Here, we show that in T. cruzi infection, all plasmablasts detected had higher surface expression of PD-L1, than other mononuclear cells. PD-L1hi plasmablasts were induced in vivo in an antigen-specific manner and required help from Bcl-6+CD4+T cells. PD-L1hi expression was not a characteristic of all antibody-secreting cells since plasma cells found during the chronic phase of infection express PD-L1 but at lower levels. PD-L1hi plasmablasts were also present in mice infected with Plasmodium or with lymphocytic choriomeningitis virus, but not in mice with autoimmune disorders or immunized with T cell-dependent antigens. PD-L1hi plasmablasts suppressed T cell response, via PD-L1, in vitro and in vivo. Thus, this study reveals that extrafollicular PD-L1hi plasmablasts, which precede the germinal center (CG) response, are a suppressive population in infections that may influence T cell response.Brief summaryPathogens develop different strategies to settle in the host. We identified a plasmablats population induced by pathogens in acute infections which suppress T cell response.

scholarly journals In vivo splenic CD11c cells downregulate CD4 T-cell response thereby decreasing systemic immunity to gene-modified tumour cell vaccine

Gene Therapy ◽  
2007 ◽  
Vol 14 (20) ◽  
pp. 1481-1491
Author(s):  
S Cayeux ◽  
B Bukarica ◽  
C Buschow ◽  
J Charo ◽  
M Bunse ◽  
...  
Keyword(s):  
T Cell ◽  
Tumour Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Cell Vaccine ◽  
Systemic Immunity

Su.20. Analysis of the Cd4 Effector T-Cell Response to Regulation in Diabetes Mellitus

2006 ◽  
Vol 119 ◽  
pp. S166
Author(s):  
Susan Masewicz ◽  
Mindy Walker ◽  
Megan VanLandeghan ◽  
Jane Buckner ◽  
Gerald Nepom
Keyword(s):  
Diabetes Mellitus ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Effector T Cell

scholarly journals Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1284
Author(s):  
Natalia Trempolec ◽  
Charline Degavre ◽  
Bastien Doix ◽  
Davide Brusa ◽  
Cyril Corbet ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Lipid Droplet ◽  
T Cell Activation ◽  
Cell Response ◽  
Cell Activation ◽  
Transforming Growth Factor ◽  
T Cell Response ◽  
Mesenchymal Transition

For poorly immunogenic tumors such as mesothelioma there is an imperious need to understand why antigen-presenting cells such as dendritic cells (DCs) are not prone to supporting the anticancer T cell response. The tumor microenvironment (TME) is thought to be a major contributor to this DC dysfunction. We have reported that the acidic TME component promotes lipid droplet (LD) formation together with epithelial-to-mesenchymal transition in cancer cells through autocrine transforming growth factor-β2 (TGF-β2) signaling. Since TGF-β is also a master regulator of immune tolerance, we have here examined whether acidosis can impede immunostimulatory DC activity. We have found that exposure of mesothelioma cells to acidosis promotes TGF-β2 secretion, which in turn leads to LD accumulation and profound metabolic rewiring in DCs. We have further documented how DCs exposed to the mesothelioma acidic milieu make the anticancer vaccine less efficient in vivo, with a reduced extent of both DC migratory potential and T cell activation. Interestingly, inhibition of TGF-β2 signaling and diacylglycerol O-acyltransferase (DGAT), the last enzyme involved in triglyceride synthesis, led to a significant restoration of DC activity and anticancer immune response. In conclusion, our study has identified that acidic mesothelioma milieu drives DC dysfunction and altered T cell response through pharmacologically reversible TGF-β2-dependent mechanisms.

scholarly journals The Primary in vivo Murine Cytotoxic T Cell Response to the Flavivirus, West Nile

1987 ◽  
Vol 68 (7) ◽  
pp. 2001-2006 ◽  
Author(s):  
A. M. Kesson ◽  
R. V. Blanden ◽  
A. Mullbacher
Keyword(s):  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Cytotoxic T Cell ◽  
West Nile

scholarly journals In Vivo and In Vitro Effects of Antituberculosis Treatment on Mycobacterial Interferon-γ T Cell Response

PLoS ONE ◽  
2009 ◽  
Vol 4 (4) ◽  
pp. e5187 ◽  
Author(s):  
Ilaria Sauzullo ◽  
Fabio Mengoni ◽  
Miriam Lichtner ◽  
Anna Paola Massetti ◽  
Raffaella Rossi ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Interferon Γ ◽  
T Cell Response ◽  
Antituberculosis Treatment ◽  
In Vitro Effects
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