Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

2015 ◽  
Vol 93 (6) ◽  
pp. 575-580 ◽  
Author(s):  
Imran G House ◽  
Kevin Thia ◽  
Amelia J Brennan ◽  
Richard Tothill ◽  
Alexander Dobrovic ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Healthy Individuals ◽  
Killer Cells ◽  
The Common

scholarly journals NKG2D functions as an activating receptor on natural killer cells in the common marmoset (Callithrix jacchus)

2014 ◽  
Vol 26 (11) ◽  
pp. 597-606 ◽  
Author(s):  
Masamichi Watanabe ◽  
Yohei Kudo ◽  
Mitsuko Kawano ◽  
Masafumi Nakayama ◽  
Kyohei Nakamura ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Common Marmoset ◽  
Callithrix Jacchus ◽  
Killer Cells ◽  
The Common ◽  
Activating Receptor

scholarly journals The relationship between the frequency of the common cold and the activities of natural killer cells

2000 ◽  
Vol 4 (4) ◽  
pp. 212-216 ◽  
Author(s):  
Ming Xu ◽  
Takashi Muto ◽  
Tosio Yabe ◽  
Fumiko Nagao ◽  
Yasushi Fukuwatart ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Common Cold ◽  
Killer Cells ◽  
The Common ◽  
The Relationship

scholarly journals Mild Hyperbaric Oxygen Exposure Increases Cd16dim-cd56bright Natural Killer Cells In Healthy Individuals

2021 ◽  
Vol 53 (8S) ◽  
pp. 489-489
Author(s):  
Hidemi Fujino ◽  
Hideki Amano ◽  
Akiko Fujisawa ◽  
Akihiko Mizushima ◽  
Badur Un Nisa ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Hyperbaric Oxygen ◽  
Healthy Individuals ◽  
Killer Cells ◽  
Oxygen Exposure ◽  
Hyperbaric Oxygen Exposure ◽  
Mild Hyperbaric Oxygen

scholarly journals Increased expression of activating receptors and up-regulated function of natural killer cells in peripheral blood of patients with HBV-related hepatocellular carcinoma

2020 ◽  
Author(s):  
Yan-tao Pei ◽  
Wen-fang Yuan ◽  
Qian Zhang ◽  
Xin-yan Yue ◽  
Xiu-li Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Inhibitory Receptor ◽  
Healthy Individuals ◽  
Killer Cells ◽  
Cell Counts ◽  
Activating Receptors ◽  
B Virus

Abstract Background This study aimed to investigate and identify the characteristics of peripheral natural killer (NK) cells of hepatocellular carcinoma (HCC) patients who infected with hepatitis B virus. Methods Flow cytometry was utilized to identify the frequency and receptors of NK cells, in the meantime, to analyze the killing ability and cytotoxicity of NK cells of patients of which embraced 36 cases of HBV-associated HCC, 34 individuals who suffered in HBV-associated cirrhosis (LC) and 30 non-liver dysfunction healthy individuals as control (HC). Results Cell counts for NK and CD56dimNK were reduced in patients with HCC, however, there was no statistically significant. The count of CD56brightNK cells in the HCC subpopulation was remarkably higher than the subset of the HC (P < 0.05). The counts of activated receptors of NKG2D/p30 were elevated in patients with HCC, as well as the NKp44 and the NKp46. There was no statistically meaningful difference of inhibitory receptor expressions such as CD158a/b on peripheral NK cells of patients with HCC and LC and those with HC (P > 0.05). Following an IL-12 stimulation, the production of INF-γ/-α of patients with HCC was less than those produced by HC (P < 0.05). However, killing activity and cytotoxicity, as the primary responsibilities of the natural killer cells, were upregulated in HCC individuals. HBV associated individuals were found lower counts and capability to produce cytokines of natural killer cells. Nevertheless, the killing capacity and cytotoxicity of NK cells were stronger than those of the HC group. This may be associated with the increased activating receptors expression of NK cells. Conclusions This study demonstrated that the activating receptors expression and the cytotoxicity of NK cells in the blood were independent predictors of development in HCC patients, and the recovery of NKG2D+CD56dim NK cells could increase the prognostic value.

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