Uncontrolled triggering of programmed cell death (apoptosis) in haematopoietic stem cells: A new hypothesis for the pathogenesis of aplastic anaemia

1996 ◽  
Vol 74 (2) ◽  
pp. 159-162 ◽  
Author(s):  
FRANCESCO LAVEDER ◽  
RENZO MARCOLONGO
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Aplastic Anaemia ◽  
Haematopoietic Stem Cells ◽  
New Hypothesis

Apoptosis in Degenerative Diseases of the Basal Ganglia

1998 ◽  
Vol 4 (4) ◽  
pp. 301-311 ◽  
Author(s):  
Robert E. Burke
Keyword(s):  
Cell Death ◽  
Basal Ganglia ◽  
Programmed Cell Death ◽  
Direct Evidence ◽  
Normal Development ◽  
Dopamine Neurons ◽  
Degenerative Diseases ◽  
Morphological Markers ◽  
Degenerative Disorders ◽  
New Hypothesis

Degenerative disorders of the basal ganglia are characterized by disturbances of motor control. Prototypic examples are Parkinson's disease, which is caused by degeneration of dopamine neurons of the substantia nigra, and Huntington's disease, which is caused by degeneration of neurons of the striatum. In recent years, it has been postulated that some of these disorders may be caused by programmed cell death or apoptosis, a genetically regulated form of cell death. There is clear evidence that apoptosis occurs in neurons of the basal ganglia during normal development, that it can be regulated, and that it can be induced in some animal models of these disorders. Although there is some suggestive direct evidence that apoptosis may occur in the human brain in these disorders, the evidence to date is partial and not yet compelling. Nevertheless, programmed cell death is an important new hypothesis for the pathogenesis of these disorders and warrants vigorous further investigation, particularly with molecular markers in addition to classic morphological markers. The concept of programmed cell death is relevant not only to the pathogenesis of these diseases but also to therapeutic issues, such as transplantation approaches.

scholarly journals Periodontal Ligament Stem Cells Regulate B Lymphocyte Function via Programmed Cell Death Protein 1

Stem Cells ◽  
2013 ◽  
Vol 31 (7) ◽  
pp. 1371-1382 ◽  
Author(s):  
Ousheng Liu ◽  
Junji Xu ◽  
Gang Ding ◽  
Dayong Liu ◽  
Zhipeng Fan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Periodontal Ligament ◽  
B Lymphocyte ◽  
Lymphocyte Function ◽  
Periodontal Ligament Stem Cells ◽  
Cell Death Protein

scholarly journals Targeting Programmed Cell Death to Improve Stem Cell Therapy: Implications for Treating Diabetes and Diabetes-Related Diseases

2021 ◽  
Vol 9 ◽  
Author(s):  
Qi Zhang ◽  
Xin-xing Wan ◽  
Xi-min Hu ◽  
Wen-juan Zhao ◽  
Xiao-xia Ban ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Stem Cell ◽  
Programmed Cell Death ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Therapeutic Effects ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Wide Range

Stem cell therapies have shown promising therapeutic effects in restoring damaged tissue and promoting functional repair in a wide range of human diseases. Generations of insulin-producing cells and pancreatic progenitors from stem cells are potential therapeutic methods for treating diabetes and diabetes-related diseases. However, accumulated evidence has demonstrated that multiple types of programmed cell death (PCD) existed in stem cells post-transplantation and compromise their therapeutic efficiency, including apoptosis, autophagy, necroptosis, pyroptosis, and ferroptosis. Understanding the molecular mechanisms in PCD during stem cell transplantation and targeting cell death signaling pathways are vital to successful stem cell therapies. In this review, we highlight the research advances in PCD mechanisms that guide the development of multiple strategies to prevent the loss of stem cells and discuss promising implications for improving stem cell therapy in diabetes and diabetes-related diseases.

scholarly journals Transplantation of neural stem cells in the mouse model of ischemic brain stroke and expression of genes involved in programmed cell death

2018 ◽  
Vol 59 (5) ◽  
pp. 203-212
Author(s):  
Valentina Hribljan ◽  
Iva Salamon ◽  
Arijana Đemaili ◽  
Ivan Alić ◽  
Dinko Mitrečić
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Mouse Model ◽  
Neural Stem Cells ◽  
Ischemic Brain ◽  
Expression Of Genes ◽  
Brain Stroke

scholarly journals Programmed cell death 4 inhibits proliferation and differentiation and induces apoptosis of human mesenchymal stem cells through suppressing the Wnt/β-catenin pathway

RSC Advances ◽  
2017 ◽  
Vol 7 (43) ◽  
pp. 26566-26573 ◽  
Author(s):  
Yang Liu ◽  
Dongyue Su ◽  
Tao Song
Keyword(s):  
Stem Cells ◽  
Cell Death ◽  
Mesenchymal Stem Cells ◽  
Programmed Cell Death ◽  
Human Mesenchymal Stem Cells ◽  
Proliferation And Differentiation ◽  
Programmed Cell Death 4

PDCD4 was closely related to the proliferation and the apoptosis of OP-hMSCs in osteoporosis.

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