MHC proteins and heparan sulphate proteoglycans regulate murine cytomegalovirus infection

1995 ◽  
Vol 73 (4) ◽  
pp. 308-315 ◽  
Author(s):  
PATRICIA PRICE ◽  
RICHARD JN ALLCOCK ◽  
DEIRDRE R COOMBE ◽  
GEOEFREY R SHELLAM ◽  
JAMES McCLUSKEY
Keyword(s):  
Cytomegalovirus Infection ◽  
Heparan Sulphate ◽  
Murine Cytomegalovirus ◽  
Heparan Sulphate Proteoglycans

scholarly journals What Are the Potential Roles of Nuclear Perlecan and Other Heparan Sulphate Proteoglycans in the Normal and Malignant Phenotype

2021 ◽  
Vol 22 (9) ◽  
pp. 4415
Author(s):  
Anthony J. Hayes ◽  
James Melrose
Keyword(s):  
Gene Expression ◽  
Nuclear Envelope ◽  
Annulus Fibrosus ◽  
Heparan Sulphate ◽  
Cell Types ◽  
Malignant Cell ◽  
Cytoskeletal Proteins ◽  
Nucleus Pulposus Cells ◽  
Malignant Phenotype ◽  
Heparan Sulphate Proteoglycans

The recent discovery of nuclear and perinuclear perlecan in annulus fibrosus and nucleus pulposus cells and its known matrix stabilizing properties in tissues introduces the possibility that perlecan may also have intracellular stabilizing or regulatory roles through interactions with nuclear envelope or cytoskeletal proteins or roles in nucleosomal-chromatin organization that may regulate transcriptional factors and modulate gene expression. The nucleus is a mechano-sensor organelle, and sophisticated dynamic mechanoresponsive cytoskeletal and nuclear envelope components support and protect the nucleus, allowing it to perceive and respond to mechano-stimulation. This review speculates on the potential roles of perlecan in the nucleus based on what is already known about nuclear heparan sulphate proteoglycans. Perlecan is frequently found in the nuclei of tumour cells; however, its specific role in these diseased tissues is largely unknown. The aim of this review is to highlight probable roles for this intriguing interactive regulatory proteoglycan in the nucleus of normal and malignant cell types.

Murine Cytomegalovirus Infection Leads to Increased Levels of Transplant Arteriosclerosis in a Murine Aortic Allograft Model

2010 ◽  
Vol 90 (4) ◽  
pp. 373-379 ◽  
Author(s):  
Christian Heim ◽  
Silke Abele-Ohl ◽  
Sebastian Eckl ◽  
Martina Ramsperger-Gleixner ◽  
Shohreh Mahmoudian ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Murine Cytomegalovirus ◽  
Aortic Allograft ◽  
Transplant Arteriosclerosis

Heparan sulphate proteoglycans in Alzheimer's disease and amyloid‐related disorders

2003 ◽  
Vol 2 (8) ◽  
pp. 482-492 ◽  
Author(s):  
Jack van Horssen ◽  
Pieter Wesseling ◽  
Lambert PWJ van den Heuvel ◽  
Robert MW de Waal ◽  
Marcel M Verbeek
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Heparan Sulphate ◽  
Heparan Sulphate Proteoglycans

scholarly journals Four Distinct Patterns of Memory CD8 T Cell Responses to Chronic Murine Cytomegalovirus Infection

2006 ◽  
Vol 177 (1) ◽  
pp. 450-458 ◽  
Author(s):  
Michael W. Munks ◽  
Kathy S. Cho ◽  
Amelia K. Pinto ◽  
Sophie Sierro ◽  
Paul Klenerman ◽  
...  
Keyword(s):  
T Cell ◽  
Cytomegalovirus Infection ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Murine Cytomegalovirus ◽  
Cell Responses ◽  
Memory Cd8 T Cell
Sign in / Sign up

Export Citation Format

Share Document