Differences in antigen-binding affinity caused by single amino acid substitution in the variable region of the heavy chain

1993 ◽  
Vol 71 (4) ◽  
pp. 239-247 ◽  
Author(s):  
JIM XIANG ◽  
ZHINAN CHEN ◽  
LOUIS T. J. DELBAERE ◽  
ENWU LIU
Keyword(s):  
Amino Acid ◽  
Binding Affinity ◽  
Amino Acid Substitution ◽  
Heavy Chain ◽  
Variable Region ◽  
Single Amino Acid Substitution ◽  
Single Amino Acid ◽  
Antigen Binding

Drastic change in idiotypic but not antigen-binding specificity of an antibody by a single amino-acid substitution

Nature ◽  
1985 ◽  
Vol 315 (6019) ◽  
pp. 506-508 ◽  
Author(s):  
Andreas Radbruch ◽  
Siegfried Zaiss ◽  
Claudia Kappen ◽  
Marianne Brüggemann ◽  
Konrad Beyreuther ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Substitution ◽  
Binding Specificity ◽  
Drastic Change ◽  
Single Amino Acid Substitution ◽  
Single Amino Acid ◽  
Antigen Binding

scholarly journals A large compressibility change of protein induced by a single amino acid substitution

1996 ◽  
Vol 5 (3) ◽  
pp. 542-545 ◽  
Author(s):  
Kunihiko Gekko ◽  
Youjiro Tamura ◽  
Eiji Ohmae ◽  
Hideyuki Hayashi ◽  
Hiroyuki Kagamiyama ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Substitution ◽  
Single Amino Acid Substitution ◽  
Single Amino Acid
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