Gastric parietal cell development: Expression of the H+/K+ATPase subunits coincides with the biogenesis of the secretory membranes

1993 ◽  
Vol 71 (3) ◽  
pp. 191-200 ◽  
Author(s):  
JOHN M. PETTITT ◽  
BAN-HOCK TOH ◽  
JUDY M. CALLAGHAN ◽  
PAUL A. GLEESON ◽  
IAN R. VAN DRIEL
Keyword(s):  
Parietal Cell ◽  
Cell Development ◽  
Gastric Parietal Cell ◽  
Atpase Subunits

Fatty Acids in a High-Fat Diet Potentially Induce Gastric Parietal-Cell Damage and Metaplasia in Mice

2017 ◽  
Vol 152 (5) ◽  
pp. S418
Author(s):  
Yuki Hirata ◽  
Shinji Fukuda ◽  
Kazuhiko Yamada ◽  
Kazuhide Higuchi ◽  
Yuki I. Kawamura ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Parietal Cell ◽  
High Fat Diet ◽  
Cell Damage ◽  
High Fat ◽  
Gastric Parietal Cell

scholarly journals Anemia and hematinic deficiencies in gastric parietal cell antibody-positive and -negative oral mucosal disease patients with microcytosis

2017 ◽  
Vol 116 (8) ◽  
pp. 613-619 ◽  
Author(s):  
Hung-Pin Lin ◽  
Yu-Hsueh Wu ◽  
Yi-Ping Wang ◽  
Yang-Che Wu ◽  
Julia Yu-Fong Chang ◽  
...  
Keyword(s):  
Parietal Cell ◽  
Gastric Parietal Cell ◽  
Mucosal Disease ◽  
Cell Antibody ◽  
Parietal Cell Antibody

3-Dimensional Modeling of the Gastric Parietal Cell

2002 ◽  
pp. 295-304
Author(s):  
John G. Forte ◽  
Joseph G. Duman ◽  
Nimesh J. Pathak ◽  
Kent L. Mcdonald
Keyword(s):  
Parietal Cell ◽  
Gastric Parietal Cell ◽  
3 Dimensional ◽  
Dimensional Modeling

Functionally distinct pools of actin in secretory cells

2001 ◽  
Vol 281 (2) ◽  
pp. C407-C417 ◽  
Author(s):  
David A. Ammar ◽  
Phuong N. B. Nguyen ◽  
John G. Forte
Keyword(s):  
Parietal Cell ◽  
Cultured Cells ◽  
Parietal Cells ◽  
Secretory Cells ◽  
Resting Cells ◽  
Gastric Glands ◽  
Gastric Parietal Cell ◽  
Actin Organization ◽  
Isolated Gastric Glands ◽  
High Concentrations

Acid secretion by the gastric parietal cell is controlled through movement of vesicles containing the proton pump, the H+-K+-ATPase (HK). We have used latrunculin B (Lat B), which binds to monomeric actin, to investigate actin turnover in the stimulated parietal cell. In isolated gastric glands, relatively high concentrations of Lat B were required to inhibit acid accumulation (ED50∼70 μM). Cultured parietal cells stimulated in the presence of low Lat B (0.1–1 μM) have reduced lamellipodia formation and some aberrant punctate phalloidin-stained structures, but translocation of HK and vacuolar swelling appeared unaffected. High Lat B (10–50 μM) resulted in gross changes in actin organization (punctate phalloidin-stained structures throughout the cell and nucleus) and reduced translocation of HK and vacuolar swelling. Resting parietal cells treated with high Lat B showed minor effects on morphology and F-actin staining. If resting cells treated with high Lat B were washed immediately before stimulation, they exhibited a normal stimulated morphology. These data suggest distinct pools of parietal cell actin: a pool highly susceptible to Lat B primarily involved in motile function of cultured cells; and a Lat B-resistant pool, most likely microvillar filaments, that is essential for secretion. Furthermore, the stimulation process appears to accentuate the effects of Lat B, most likely through Lat B binding to monomer actin liberated by the turnover of the motile actin filament pool.

In situ measurement of pH in the secreting canaliculus of the gastric parietal cell and adjacent structures

2007 ◽  
Vol 329 (2) ◽  
pp. 313-320 ◽  
Author(s):  
Sören Schreiber ◽  
Désirée Garten ◽  
Thanh Hoa Nguyen ◽  
Manuela Konradt ◽  
Roland Bücker ◽  
...  
Keyword(s):  
Parietal Cell ◽  
In Situ Measurement ◽  
Gastric Parietal Cell ◽  
Adjacent Structures
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