CYTOCHEMICAL VARIATIONS IN THE GRANULES OF RAT MAST CELLS, AND THEIR RELATION TO MAST CELL MATURATION

1962 ◽  
Vol 40 (1) ◽  
pp. 9-16 ◽  
Author(s):  
BG Radden
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Cell Maturation ◽  
Rat Mast Cells

scholarly journals MATURATION OF RAT MAST CELLS

1966 ◽  
Vol 31 (3) ◽  
pp. 563-575 ◽  
Author(s):  
J. W. Combs
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Granular Material ◽  
Electron Microscope Study ◽  
Cell Granule ◽  
Cell Maturation ◽  
Granule Formation ◽  
Dense Granules ◽  
Mast Cell Granule ◽  
Rat Mast Cells

Electron microscope study of rat mast cell maturation corroborates certain interpretations of features of mast cell differentiation based on light microscope studies. In addition, the ultrastructural variation observed in the granules of differentiating mast cells suggests that granule formation begins with the elaboration of dense granules about 70 mµ in diameter inside Golgi vacuoles. These progranules appear to aggregate inside a membrane and fuse to form dense cords 70 to 100 mµ in diameter. These dense cords are embedded in a finely granular material possibly added to the developing granule by direct continuity between perigranular membranes and cisternae of rough endoplasmic reticulum. The dense cords and finely granular material then appear to be replaced by a mass of strands about 30 mµ in diameter, thought to be a reorganization product of the two formerly separate components. A process interpreted as compaction of the strands completes the formation of the dense, homogeneous granules observed in mature rat mast cells. The similarity between mast cell granule formation and the elaboration of other granules is considered, with special reference to rabbit polymorphonuclear leukocyte azurophil granules. The relationships between the ultrastructural, histochemical, and radioautographic characteristics of mast cell granule formation are considered, and the significance of the perigranular membrane is discussed.

scholarly journals Roles of IgE and Histamine in Mast Cell Maturation

Cells ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 2170
Author(s):  
Satoshi Tanaka ◽  
Kazuyuki Furuta
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Immunoglobulin E ◽  
Cell Maturation ◽  
Tissue Type ◽  
Human Mast Cell ◽  
Therapeutic Effects ◽  
Serum Ige ◽  
Cell Functions ◽  
Histamine Synthesis

Mast cells are activated upon immunoglobulin E (IgE)-mediated antigen stimulation, and release a wide variety of mediators, including histamine to trigger inflammatory responses. The surface expression levels of Fcε receptor I (FcεRI), a high affinity receptor of IgE, were found to be positively regulated by IgE. IgE could protect murine cultured mast cells from apoptotic cell death induced by the deprivation of interleukin-3 and a certain kind of IgE could activate immature mast cells in the absence of antigens, leading to the release of pro-inflammatory cytokines and a transient increase in histamine synthesis. Histamine synthesis in mast cells was found to be required for the maturation of murine connective tissue-type mast cells, raising the possibility that IgE indirectly modulates local mast cell maturation. Although it remains controversial to what extent this concept of “monomeric IgE effects” could have relevance in the modulation of human mast cell functions, the therapeutic effects of anti-IgE antibodies might be accounted for in terms of the decreased serum IgE concentrations. Because drastic increases in serum IgE concentrations are often observed in patients with atopic dermatitis and chronic urticaria, a close investigation of the roles of IgE in mast cell maturation should contribute to development of novel therapeutic approaches for these inflammatory diseases.

The Distribution of Mast-Cells in the Digestive Tract of Laboratory Animals: Its Bearings on the Problem of the Location of Histamine in Tissues

1956 ◽  
Vol s3-97 (38) ◽  
pp. 251-256
Author(s):  
I. MOTA ◽  
A. G. FERRI ◽  
S. YONEDA
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Guinea Pig ◽  
Digestive Tract ◽  
The Other ◽  
Laboratory Animals ◽  
Large Individual ◽  
Cell Distribution ◽  
Muscularis Mucosae ◽  
Rat Mast Cells

The mast-cell distribution in the digestive tract of the rat, dog, cat, and guinea-pig was studied. In the rat mast-cells were present in the tongue, oesophagus, and forestomach, but practically absent from the glandular stomach, duodenum, ileum, and rectum. In the other species, mast-cells were numerous throughout the whole of the digestive tract, presenting a large individual variation. In the tongue and oesophagus mast-cells were found mainly in the submucosa and lamina propria, where they were located near the epithelium. In the stomach, mast-cells were more numerous in the mucosa and concentrated in the muscularis mucosae and between the necks of the glands. In the duodenum, mast-cells were also more numerous in the mucosa, being concentrated in the muscularis mucosae and frequently also in the summit of the villi. In the ileum and rectum mast-cells were less numerous than in the stomach and duodenum, keeping the same disposition as in these. The contribution of the mastcells to the histamine content of the digestive tract is discussed.

scholarly journals Effect of removal of calcium-activated adenosine triphosphatase from rat mast cells by treatment with sodium glycocholate

1977 ◽  
Vol 168 (3) ◽  
pp. 583-585 ◽  
Author(s):  
P H Cooper ◽  
D R Stanworth
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Adenosine Triphosphatase ◽  
External Surface ◽  
Atp Release ◽  
Calcium Ionophore ◽  
Calcium Ionophore A23187 ◽  
Ionophore A23187 ◽  
Sodium Glycocholate ◽  
Rat Mast Cells

Sodium glycocholate was shown to remove a Ca2+-activated adenosine triphosphatase from the external surface of the rat mast cell without causing lysis. Sensitized mast cells pretreated with sodium glycocholate showed a decrease in histamine-releasing capacity when triggered with antigen, Synacthen and ATP. Release induced by calcium ionophore A23187 was unaffected.

scholarly journals Mast cell degranulating (MCD) peptide and its optical isomer activate GTP binding protein in rat mast cells

FEBS Letters ◽  
1991 ◽  
Vol 287 (1-2) ◽  
pp. 15-18 ◽  
Author(s):  
Ichiro Fujimoto ◽  
Kazuhiro Ikenaka ◽  
Tetsuro Kondo ◽  
Saburo Aimoto ◽  
Miyuki Kuno ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Binding Protein ◽  
Optical Isomer ◽  
Gtp Binding Protein ◽  
Gtp Binding ◽  
Mast Cell Degranulating ◽  
Rat Mast Cells
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