scholarly journals Impact of irbesartan, an angiotensin receptor blocker, on uric acid level and oxidative stress in high-risk hypertension patients

2015 ◽  
Vol 38 (11) ◽  
pp. 765-769 ◽  
Author(s):  
Ryuji Chida ◽  
Itaru Hisauchi ◽  
Shigeru Toyoda ◽  
Migaku Kikuchi ◽  
Takaaki Komatsu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
High Risk ◽  
Uric Acid Level ◽  
Acid Level ◽  
Angiotensin Receptor Blocker ◽  
Receptor Blocker ◽  
Angiotensin Receptor ◽  
And Oxidative Stress

An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection

2012 ◽  
Vol 30 (5) ◽  
pp. 1022-1028 ◽  
Author(s):  
Paul A. Smink ◽  
Stephan J.L. Bakker ◽  
Gozewijn D. Laverman ◽  
Tomas Berl ◽  
Mark E. Cooper ◽  
...  
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Angiotensin Receptor Blocker ◽  
Receptor Blocker ◽  
Angiotensin Receptor ◽  
Cardiovascular Protection ◽  
Initial Reduction

scholarly journals Uric acid shown to contribute to increased oxidative stress level independent of xanthine oxidoreductase activity in MedCity21 health examination registry

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masafumi Kurajoh ◽  
Shinya Fukumoto ◽  
Shio Yoshida ◽  
Seigo Akari ◽  
Takayo Murase ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Stress Level ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Xanthine Oxidoreductase ◽  
Ros Production ◽  
Oxidative Stress Level

AbstractUric acid has both antioxidant and pro-oxidant properties in vitro by scavenging and production of reactive oxygen species (ROS). This cross-sectional study examined whether uric acid possesses effects on oxidative stress under physiological conditions independent of xanthine oxidoreductase (XOR), which is involved in uric acid and ROS production. Serum uric acid level was measured, while plasma XOR activity was determined using our high-sensitive assay in 192 participants (91 males, 101 females) who underwent health examinations and were not taking an antihyperuricemic agent. For antioxidant potential and oxidative stress level, biological antioxidant potential (BAP) and derivative of reactive oxygen metabolites (d-ROMs) in serum, respectively, were measured. Median uric acid level and plasma XOR activity were 5.6 mg/dL and 26.1 pmol/h/mL, respectively, and BAP and d-ROMs levels were 2112.8 μmol/L and 305.5 Carr U, respectively. Multivariable regression analyses revealed no significant association of serum uric acid level with BAP level, whereas serum uric acid level showed a significant association with d-ROMs level independent of plasma XOR activity (p = 0.045), which was prominent in females (p = 0.036; p for interaction = 0.148). Uric acid might contribute to increased oxidative stress independent of XOR activity by increasing ROS production, without affecting ROS scavenging, especially in females.

scholarly journals Effects of Angiotensin Receptor Blocker on Oxidative Stress and Cardio-Renal Function in Streptozotocin-Induced Diabetic Rats

2009 ◽  
Vol 32 (8) ◽  
pp. 1411-1416 ◽  
Author(s):  
Wawaimuli Arozal ◽  
Kenichi Watanabe ◽  
Punniyakoti Thanikachalam Veeraveedu ◽  
Meilei Ma ◽  
Rajarajan Amirthalingam Thandavarayan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Renal Function ◽  
Angiotensin Receptor Blocker ◽  
Diabetic Rats ◽  
Receptor Blocker ◽  
Angiotensin Receptor
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