ANTXR2 is a potential causative gene in the genome-wide association study of the blood pressure locus 4q21

2014 ◽  
Vol 37 (9) ◽  
pp. 811-817 ◽  
Author(s):  
So Yon Park ◽  
Hyeon-Ju Lee ◽  
Su-Min Ji ◽  
Marina E Kim ◽  
Baigalmaa Jigden ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Causative Gene ◽  
Genome Wide

scholarly journals A Genome-Wide Association Study for Hypertensive Kidney Disease in Korean Men

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 751
Author(s):  
Hye-Rim Kim ◽  
Hyun-Seok Jin ◽  
Yong-Bin Eom
Keyword(s):  
Blood Pressure ◽  
Kidney Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Integrated Analysis ◽  
Eqtl Analysis ◽  
Strong Linkage Disequilibrium ◽  
Genome Wide ◽  
A Genome

Hypertension is one of the major risk factors for chronic kidney disease (CKD), and the coexistence of hypertension and CKD increases morbidity and mortality. Although many genetic factors have been identified separately for hypertension and kidney disease, studies specifically focused on hypertensive kidney disease (HKD) have been rare. Therefore, this study aimed to identify loci or genes associated with HKD. A genome-wide association study (GWAS) was conducted using two Korean cohorts, the Health Examinee (HEXA) and Korean Association REsource (KARE). Consequently, 19 single nucleotide polymorphisms (SNPs) were found to be significantly associated with HKD in the discovery and replication phases (p < 5 × 10−8, p < 0.05, respectively). We further analyzed HKD-related traits such as the estimated glomerular filtration rate (eGFR), creatinine, blood urea nitrogen (BUN), systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the 14q21.2 locus, which showed a strong linkage disequilibrium (LD). Expression quantitative trait loci (eQTL) analysis was also performed to determine whether HKD-related SNPs affect gene expression changes in glomerular and arterial tissues. The results suggested that the FANCM gene may affect the development of HKD through an integrated analysis of eQTL and GWAS and was the most significantly associated candidate gene. Taken together, this study indicated that the FANCM gene is involved in the pathogenesis of HKD. Additionally, our results will be useful in prioritizing other genes for further experiments.

scholarly journals Genome-wide association study identifies eight loci associated with blood pressure

2009 ◽  
Vol 41 (6) ◽  
pp. 666-676 ◽  
Author(s):  
Christopher Newton-Cheh ◽  
◽  
Toby Johnson ◽  
Vesela Gateva ◽  
Martin D Tobin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

PLoS Genetics ◽  
2010 ◽  
Vol 6 (10) ◽  
pp. e1001177 ◽  
Author(s):  
Sandosh Padmanabhan ◽  
Olle Melander ◽  
Toby Johnson ◽  
Anna Maria Di Blasio ◽  
Wai K. Lee ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans

PLoS Genetics ◽  
2009 ◽  
Vol 5 (7) ◽  
pp. e1000564 ◽  
Author(s):  
Adebowale Adeyemo ◽  
Norman Gerry ◽  
Guanjie Chen ◽  
Alan Herbert ◽  
Ayo Doumatey ◽  
...  
Keyword(s):  
Blood Pressure ◽  
African Americans ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents

2016 ◽  
Vol 9 (3) ◽  
pp. 266-278 ◽  
Author(s):  
Priyakumari Ganesh Parmar ◽  
H. Rob Taal ◽  
Nicholas J. Timpson ◽  
Elisabeth Thiering ◽  
Terho Lehtimäki ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Association Study ◽  
Children And Adolescents ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide
Sign in / Sign up

Export Citation Format

Share Document