scholarly journals Control of salt and volume retention cannot be ruled out as a mechanism underlying the blood pressure-lowering effect of renal denervation

2013 ◽  
Vol 36 (11) ◽  
pp. 1006-1007 ◽  
Author(s):  
Yutang Wang ◽  
Kate M Denton ◽  
Jonathan Golledge
2014 ◽  
Vol 32 (10) ◽  
pp. 2045-2053 ◽  
Author(s):  
Eva E. Vink ◽  
Willemien L. Verloop ◽  
Rianne B.C. Bost ◽  
Michiel Voskuil ◽  
Wilko Spiering ◽  
...  

2013 ◽  
Vol 34 (suppl 1) ◽  
pp. P4492-P4492
Author(s):  
W. L. Verloop ◽  
E. E. Vink ◽  
P. J. Blankestijn ◽  
E. J. Vonken ◽  
P. A. Doevendans ◽  
...  

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e292
Author(s):  
Stanislav Pekarskiy ◽  
Andrei Baev ◽  
Alla Falkovskaya ◽  
Ekaterina Sitkova ◽  
Irina Zubanova ◽  
...  

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kazuhisa Sugai ◽  
Tomoyoshi Tamura ◽  
Motoaki Sano ◽  
Shizuka Uemura ◽  
Masahiko Fujisawa ◽  
...  

AbstractA recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2 significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H2 was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H2 on hypertension, we used an implanted telemetry system to continuously monitor blood pressure. H2 exerted an anti-hypertensive effect not only during daytime rest, but also during night-time activities. Spectral analysis of blood pressure variability revealed that H2 improved autonomic imbalance, namely by suppressing the overly active sympathetic nervous system and augmenting parasympathetic nervous system activity; these effects co-occurred with the blood pressure-lowering effect. In conclusion, 1-h daily exposure to H2 exerts an anti-hypertensive effect in an animal model of hypertension.


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