scholarly journals Daily dialysis reduces pulse wave velocity in chronic hemodialysis patients

2012 ◽  
Vol 35 (5) ◽  
pp. 518-522 ◽  
Author(s):  
Lucia Di Micco ◽  
Serena Torraca ◽  
Maria Luisa Sirico ◽  
Domenico Tartaglia ◽  
Biagio Di Iorio
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Daily Dialysis

Variability of pulse wave velocity and mortality in chronic hemodialysis patients

2011 ◽  
Vol 15 (3) ◽  
pp. 326-333 ◽  
Author(s):  
Serena TORRACA ◽  
Maria Luisa SIRICO ◽  
Pasquale GUASTAFERRO ◽  
Luigi Francesco MORRONE ◽  
Filippo NIGRO ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis

scholarly journals Aortic Calcification Index and Pulse Wave Velocity in Chronic Hemodialysis Patients

1985 ◽  
Vol 13 (5) ◽  
pp. 1237-1243
Author(s):  
Susumu YUKAWA ◽  
Kazuo MORI ◽  
Osamu NISHIKAWA ◽  
Hiroshi NOMOTO ◽  
Noriko NISHIKAWA ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Aortic Calcification

scholarly journals Increased Sclerostin, but Not Dickkopf-1 Protein, Is Associated with Elevated Pulse Wave Velocity in Hemodialysis Subjects

2019 ◽  
Vol 44 (4) ◽  
pp. 679-689 ◽  
Author(s):  
Eirini Stavrinou ◽  
Pantelis A. Sarafidis ◽  
Charalampos Koumaras ◽  
Charalampos Loutradis ◽  
Panagiotis Giamalis ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Hemodialysis Patients ◽  
Applanation Tonometry ◽  
Chronic Hemodialysis ◽  
Large Set ◽  
Vascular Changes ◽  
Dickkopf 1

Background: Sclerostin and Dickkopf-1 (Dkk-1) proteins are inhibitors of the canonical Wnt/β-catenin bone pathway. Pilot data suggest that sclerostin may be involved in vascular changes in chronic kidney disease (CKD), but data on the effects of Dkk-1 are scarce. This is the first study investigating simultaneously the associations of sclerostin and Dkk-1 with arterial stiffness in hemodialysis patients. Methods: A total of 80 patients on chronic hemodialysis had carotid-femoral pulse wave velocity (PWV), central blood pressure (BP), and wave reflections evaluated with applanation tonometry (Sphygmocor) on a midweek non-dialysis day. Serum levels of sclerostin and Dkk-1 were measured with ELISA. A large set of demographic, comorbid, laboratory, and drug parameters were used in the analyses. Results: Subjects with PWV >9.5 m/s (high arterial stiffness group, n = 40) were older, had higher BMI, higher prevalence of hypertension, diabetes, and coronary heart disease, and higher peripheral systolic BP, central systolic BP, C-reactive protein, and serum sclerostin (p = 0.02), but similar Dkk-1, compared to subjects with low PWV. When dichotomizing the population by sclerostin levels, those with high sclerostin had higher PWV than patients with low sclerostin levels (10.63 ± 2.71 vs. 9.77 ± 3.13, p = 0.048). Increased sclerostin (>200 pg/mL) was significantly associated with increased PWV (>9.5 m/s; HR 2.778, 95% CI 1.123–6.868 per pg/mL increase); this association remained significant after stepwise adjustment for Dkk-1, intact parathyroid hormone, and calcium × phosphate product. In contrast, no association was noted between Dkk-1 and PWV (HR 1.000, 95% CI 0.416–2.403). Conclusion: Serum sclerostin is associated with PWV independently of routine markers of CKD-MBD in hemodialysis patients. In contrast, Dkk-1 has no association with arterial stiffness and is not pathophysiologically involved in relevant vascular changes.

P1270INCREASED SCLEROSTIN, BUT NOT DKK-1 PROTEIN, IS ASSOCIATED WITH ELEVATED PULSE WAVE VELOCITY IN HEMODIALYSIS SUBJECTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
EIRINI STAVRINOU ◽  
Panteleimon Sarafidis ◽  
Charalampos Koumaras ◽  
Charalampos Loutradis ◽  
Panagiotis Giamalis ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Serum Levels ◽  
Hemodialysis Patients ◽  
Applanation Tonometry ◽  
Chronic Hemodialysis ◽  
Large Set ◽  
Vascular Changes

Abstract Background and Aims Sclerostin and Dickkopf-1 (Dkk-1) protein are inhibitors of the canonical Wnt/β-catenin bone pathway. Pilot data suggest that sclerostin may be involved in vascular changes in CKD, but data on Dkk-1 effects are scarce. This is the first study investigating simultaneously the associations of sclerostin and Dkk-1 with arterial stiffness in hemodialysis patients. Method 80 patients on chronic hemodialysis had carotid-femoral pulse wave velocity (PWV), central BP and wave reflections evaluated with applanation tonometry (Sphygmocor) in a mid-week non-dialysis day. Serum levels of sclerostin and Dkk-1 were measured with ELISA. A large set of demographic, co-morbid, laboratory and drug parameters were used in the analyses. Results Subjects with PWV>9.5 m/sec (high arterial stiffness group, n=40) were older, had higher BMI, higher prevalence of hypertension, diabetes and coronary-heart-disease and higher peripheral SBP, central SBP, C- reactive protein and serum sclerostin (p=0.02), but similar Dkk-1 compared to subjects with low PWV. When dichotomizing the population by sclerostin levels, those with high sclerostin had higher PWV than patients with low sclerostin levels (10.63±2.71 vs 9.77±3.13, p=0.048). Increased sclerostin (>200 pg/ml) was significantly associated with increased PWV (>9.5 m/s) (HR:2.778, 95%CI:1.123-6.868, per pg/ml increase); this association remained significant after stepwise adjustment for Dkk-1, iPTH and calcium x phosphate product. In contrast, no association was noted between Dkk-1 and PWV (HR: 1.000, 95%CI: 0.416-2.403). Conclusion Serum sclerostin is associated with PWV independently of routine markers of CKD-MBD in hemodialysis patients. In contrast Dkk-1 has no association with arterial stiffness and is rather not pathophysiologically involved in relevant vascular changes.

Effect of nifedipine administration on pulse wave velocity (PWV) of chronic hemodialysis patients—2-year trial

1990 ◽  
Vol 4 (S5) ◽  
pp. 987-990 ◽  
Author(s):  
Yasushi Saito ◽  
Kohji Shirai ◽  
Junji Uchino ◽  
Masayuki Okazawa ◽  
Yoshihiro Hattori ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis

scholarly journals Analysis of pulse wave velocity and autonomic function in chronic hemodialysis patients

2004 ◽  
Vol 37 (11) ◽  
pp. 1989-1998
Author(s):  
Taeko Suenaga ◽  
Tetsuya Ogawa ◽  
Ken Tsuchiya ◽  
Takashi Akiba ◽  
Hiroshi Nihei
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Autonomic Function ◽  
Pulse Wave ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis

Factors Related to Pulse Wave Velocity and Augmentation Index in Chronic Hemodialysis Patients

Renal Failure ◽  
2011 ◽  
Vol 33 (10) ◽  
pp. 957-963 ◽  
Author(s):  
Gülperi elik ◽  
Meltem Sezis Demirci ◽  
Murat Tumuklu ◽  
Gulay Ascı ◽  
Savas Sipahi ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis
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