scholarly journals Aldosterone-induced osteopontin gene transcription in vascular smooth muscle cells involves glucocorticoid response element

2011 ◽  
Vol 34 (12) ◽  
pp. 1283-1287 ◽  
Author(s):  
Arihiro Kiyosue ◽  
Daisuke Nagata ◽  
Masahiro Myojo ◽  
Tomohiko Sato ◽  
Masao Takahashi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Gene Transcription ◽  
Muscle Cells ◽  
Glucocorticoid Response Element ◽  
Response Element ◽  
Glucocorticoid Response

scholarly journals Apoptosis Induced by Inhibition of Cyclic AMP Response Element–Binding Protein in Vascular Smooth Muscle Cells

Circulation ◽  
2003 ◽  
Vol 108 (10) ◽  
pp. 1246-1252 ◽  
Author(s):  
Tomotake Tokunou ◽  
Rei Shibata ◽  
Hisashi Kai ◽  
Toshihiro Ichiki ◽  
Takashi Morisaki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cyclic Amp ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Binding Protein ◽  
Muscle Cells ◽  
Response Element ◽  
Element Binding Protein ◽  
Cyclic Amp Response Element

Role of cyclic AMP response element binding protein (CREB) in angiotensin II-induced responses in vascular smooth muscle cells

2020 ◽  
Author(s):  
Vanessa Truong ◽  
Madhu B Anand-Srivastava ◽  
Ashok K Srivastava
Keyword(s):  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Muscle Cells ◽  
Ang Ii ◽  
Response Element ◽  
And Migration

Cyclic adenosine monophosphate response element (CRE) binding protein (CREB) is a nuclear transcription factor that regulates the transcription of several genes containing the CRE sites in their promoters. CREB is activated by phosphorylation on a key serine residue, Ser 311, in response to a wide variety of extracellular stimuli including angiotensin II (Ang II). Ang II is an important vasoactive peptide and mitogen for vascular smooth muscle cells (VSMC) that in addition to regulating the contractile response in VSMC also plays an important role in phenotypic switch of vascular smooth muscle cells (VSMC) from contractile to a synthetic state. The synthetic VSMC are known to exhibit proliferative and migratory properties due to hyperactivation of Ang II-induced signaling events. Ang II has been shown to induce CREB phosphorylation/activation and transcription of genes implicated in proliferation, growth and migration. Here, we have highlighted some key studies that have demonstrated an important role of CREB in Ang II-mediated gene transcription, proliferation, hypertrophy and migration of VSMC.

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