scholarly journals Altered function of nitrergic nerves inhibiting sympathetic neurotransmission in mesenteric vascular beds of renovascular hypertensive rats

2010 ◽  
Vol 33 (5) ◽  
pp. 485-491 ◽  
Author(s):  
Toshihiro Koyama ◽  
Yukako Hatanaka ◽  
Xin Jin ◽  
Ayako Yokomizo ◽  
Hidetoshi Fujiwara ◽  
...  
Keyword(s):  
Hypertensive Rats ◽  
Sympathetic Neurotransmission ◽  
Vascular Beds ◽  
Nitrergic Nerves

Attenuated microvascular alterations in coarctation hypertension

1989 ◽  
Vol 256 (1) ◽  
pp. H213-H221 ◽  
Author(s):  
D. L. Stacy ◽  
R. L. Prewitt
Keyword(s):  
Fourth Order ◽  
Vascular Tone ◽  
Structural Parameters ◽  
Renal Hypertension ◽  
Second Order ◽  
Hypertensive Rats ◽  
Third Order ◽  
Flow Dependence ◽  
Vascular Beds ◽  
Microvascular Alterations

Arteriolar vasoconstriction, structural reductions in dilated diameter, and rarefaction have been observed in vascular beds with chronic renal hypertension. To determine their pressure or flow dependence, these functional and structural parameters were studied in the developing and chronic stages of coarctation hypertension in the cremaster muscle, a normotensive skeletal muscle bed that is protected from the effects of elevated microvascular pressures. Hypertension was produced in rats by placing a silver clip around the abdominal aorta above the branches of the renal arteries. In hypertensive rats, resting diameters were reduced in second-order arterioles after 4 and 8 wk, in third-order arterioles after 2, 4, and 8 wk, and in fourth-order arterioles after 4 and 8 wk, vs. controls. Vascular tone was elevated in second-order arterioles after 2, 4, and 8 wk and in third- and fourth-order arterioles after 8 wk in hypertensive rats. No increases in medial-intimal area were found at any stage of hypertension in any arteriolar order. The density of small arterioles (3rd-5th orders) was reduced by 20% in hypertensive rats at 8 wk but was unchanged at the other time periods. These arteriolar alterations, especially the absence of structural reductions in diameter, are attenuated compared with those observed in one-kidney, one-clip hypertension and suggest that most of the arteriolar alterations that occur in renal hypertension are pressure or flow dependent.

The Ratio between Thickness of Media and Internal Radius in Cerebral, Mesenteric and Renal Arterial Vessels in Spontaneously Hypertensive Rats

1979 ◽  
Vol 57 (s5) ◽  
pp. 27s-29s ◽  
Author(s):  
C. Nordborg ◽  
B. B. Johansson
Keyword(s):  
Cerebral Arteries ◽  
Radius Ratio ◽  
Mesenteric Arteries ◽  
Hypertensive Rats ◽  
Vascular Abnormality ◽  
Spontaneously Hypertensive ◽  
Internal Radius ◽  
Vascular Beds ◽  
Wistar Kyoto ◽  
The Brain

1. Larger arterial vessels of 15-day-old spontaneously hypertensive (SH) rats showed significantly greater media/internal radius ratio than those of Wistar—Kyoto rats in the brain, kidney and mesentery. 2. Since larger cerebral and renal arteries of adult SH rats did not differ from controls the above results indicate the presence of a non-pressure-dependent vascular abnormality in young SH rats. 3. There were marked differences between the vascular beds of adult SH rats in the increase of media/radius ratio. Thus the changes were evident in all sizes of mesenteric arteries but only in the smallest cerebral arteries.

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