scholarly journals Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: the Ohasama study

2011 ◽  
Vol 34 (4) ◽  
pp. 530-535 ◽  
Author(s):  
Takuo Hirose ◽  
Masahiro Hashimoto ◽  
Kazuhito Totsune ◽  
Hirohito Metoki ◽  
Azusa Hara ◽  
...  
2005 ◽  
Vol 28 (4) ◽  
pp. 345-349 ◽  
Author(s):  
Mohammad SAEED ◽  
Danish SALEHEEN ◽  
Sammer SIDDIQUI ◽  
Aisha KHAN ◽  
Zahid A. BUTT ◽  
...  

Hypertension ◽  
2000 ◽  
Vol 36 (suppl_1) ◽  
pp. 704-704
Author(s):  
Montserrat Enjuto ◽  
Pablo Inigo ◽  
Antonio Francino ◽  
Elisenda Gomez-Angelats ◽  
Josep M Campistol Alejandro ◽  
...  

P61 The aim of the study was to evaluate the possible association between two TGF-β1 gene polymorphisms and left ventricular hypertrophy in a group of essential hypertensive patients (EH). Ninety-three non treated EH underwent 24-hour ambulatory blood pressure, two-dimensional guided M-mode echocardiography in order to measure left ventricular mass index (LVMI), and TGF-β1 Leu 10 /Pro and Arg 25 /Pro polymorphism genotyping. As shown in the table, 24-h SBP and DBP were significantly higher in homozygous patients for the Arg 25 allele of the TGF-β1 gene. Likewise, homozygous patients for the Leu 10 allele and homozygous patients for the Arg 25 allele of the TGF-β1 gene had significanlty higher LVMI. We conclude that these TGF-β1 gene polymorphisms are associated with the severity of blood pressure and left ventricular hypertrophy in EH patients.


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