scholarly journals C-reactive protein is associated with cigarette smoking-induced hyperfiltration and proteinuria in an apparently healthy population

2010 ◽  
Vol 33 (11) ◽  
pp. 1129-1136 ◽  
Author(s):  
Rani Sauriasari ◽  
Noriko Sakano ◽  
Da-Hong Wang ◽  
Jiro Takaki ◽  
Kei Takemoto ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Healthy Population ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Apparently Healthy

scholarly journals Evaluation of Four Automated High-Sensitivity C-Reactive Protein Methods: Implications for Clinical and Epidemiological Applications

2000 ◽  
Vol 46 (4) ◽  
pp. 461-468 ◽  
Author(s):  
William L Roberts ◽  
Rachel Sedrick ◽  
Linda Moulton ◽  
Anthony Spencer ◽  
Nader Rifai
Keyword(s):  
Large Scale ◽  
Clinical Laboratory ◽  
High Sensitivity ◽  
Reference Interval ◽  
Healthy Population ◽  
C Reactive Protein ◽  
Prognostic Information ◽  
Reactive Protein ◽  
Hs Crp ◽  
Apparently Healthy

Abstract Background: C-reactive protein (CRP) can provide prognostic information about the risk of developing atherosclerotic complications in apparently healthy patients. This new clinical application requires quantification of CRP concentrations below those traditionally measured in the clinical laboratory. Methods: The Dade Behring BN II, the Abbott IMx, the Diagnostic Products Corporation IMMULITE, and the Beckman Coulter IMMAGE are four automated analyzers with high-sensitivity CRP (hs-CRP) methods. We evaluated these assays for precision, linearity, and comparability with samples from 322 apparently healthy blood donors. Results: The imprecision (CV) of the BN II, IMx, IMMULITE, and IMMAGE methods was ≤7.6%, ≤12%, ≤9.8%, and ≤9.7% at 3.5 mg/L, respectively. The BN II, IMx, IMMULITE, and IMMAGE methods were linear down to ≤0.30, ≤0.32, ≤0.85, and 2.26 mg/L, respectively. CRP concentrations demarcating each quartile in a healthy population were method dependent. The IMx method gave results comparable to the BN II method for values in the reference interval. The IMMULITE method had a positive intercept compared with the BN II method. The IMMAGE method demonstrated more scatter and a positive intercept compared with the BN II method, which may reflect the fact that it is a less sensitive assay. Conclusions: The four hs-CRP methods exhibited differences in results for a healthy population. Additional standardization efforts are required to ensure that hs-CRP results can be related to large-scale epidemiologic studies.

scholarly journals Evaluation of Nine Automated High-Sensitivity C-Reactive Protein Methods: Implications for Clinical and Epidemiological Applications. Part 2

2001 ◽  
Vol 47 (3) ◽  
pp. 418-425 ◽  
Author(s):  
William L Roberts ◽  
Linda Moulton ◽  
Terence C Law ◽  
Genesis Farrow ◽  
Margaret Cooper-Anderson ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Clinical Laboratory ◽  
Limit Of Detection ◽  
High Sensitivity ◽  
Healthy Population ◽  
C Reactive Protein ◽  
Prognostic Information ◽  
Reactive Protein ◽  
Hs Crp ◽  
Apparently Healthy

Abstract Background: C-Reactive protein (CRP) can provide prognostic information about risk of future coronary events in apparently healthy subjects. This application requires higher sensitivity assays than have traditionally been available in the clinical laboratory. Methods: Nine high-sensitivity CRP (hs-CRP) methods from Dade Behring, Daiichi, Denka Seiken, Diagnostic Products Corporation, Iatron, Kamiya, Olympus, Roche, and Wako were evaluated for limit of detection, linearity, precision, prozone effect, and comparability with samples from 388 apparently healthy individuals. Results: All methods had limits of detection that were lower than the manufacturers’ claimed limit of quantification except for the Kamiya, Roche, and Wako methods. All methods were linear at 0.3–10 mg/L. The Diagnostic Products Corporation, Kamiya, Olympus, and Wako methods had imprecision (CVs) >10% at 0.15 mg/L. The Iatron, Olympus, and Wako methods demonstrated prozone effects at hs-CRP concentrations of 12, 206, and 117 mg/L, respectively. hs-CRP concentrations demarcating each quartile in a healthy population were method-dependent. Ninety-two to 95% of subjects were classified into the same quartile of hs-CRP established by the Dade Behring method by the Denka Seiken, Diagnostic Products Corporation, Iatron, and Wako methods. In contrast, 68–77% of subjects were classified into the same quartile by the Daiichi, Kamiya, Olympus, and Roche methods. No subject varied by more than one quartile by any method. Conclusions: Four of the nine examined hs-CRP methods classified apparently healthy subjects into quartiles of hs-CRP similar to the classifications assigned by the comparison method. Additional standardization efforts are required because an individual patient’s results will be interpreted using population-based cutpoints.

scholarly journals Sarcopenia, severe anxiety and increased C-reactive protein are associated with severe fatigue in patients with inflammatory bowel diseases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Laura Tasson ◽  
Fabiana Zingone ◽  
Brigida Barberio ◽  
Romina Valentini ◽  
Pamela Ballotta ◽  
...  
Keyword(s):  
Fecal Calprotectin ◽  
Healthy Population ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Severe Fatigue ◽  
High Prevalence ◽  
Bowel Diseases ◽  
Moderate Fatigue ◽  
Inflammatory Bowel ◽  
Severe Anxiety

AbstractPatients with inflammatory bowel disease (IBD) report fatigue more frequently than healthy population, but the precise mechanisms underlying its presence are unknown. This study aimed to evaluate the prevalence of fatigue in IBD and its relation with potential causative factors. A survey on fatigue, depression, anxiety, sleep disorders, and the presence of sarcopenia and malnutrition, was sent by email to 244 IBD outpatients of the Gastroenterology Unit of Academic Hospital of Padua. Demographics and clinical data, including the levels of fecal calprotectin (FC) and C-reactive protein (CRP), and current pharmacological treatments were obtained from patients’ medical records. Ninety-nine (40.5%) subjects answered the survey. Ninety-two (92.9%) patients reported fatigue, with sixty-six having mild to moderate fatigue and twenty-six severe fatigue. Multivariate analysis showed that abnormal values of CRP (OR 5.1), severe anxiety (OR 3.7) and sarcopenia (OR 4.4) were the factors independently associated with severe fatigue. Fatigue has a high prevalence in subject affected by IBD. Subjects with altered CRP, sarcopenia and severe anxiety appear more at risk of severe fatigue.

scholarly journals The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Ying Tang ◽  
Peifen Liang ◽  
Junzhe Chen ◽  
Sha Fu ◽  
Bo Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Healthy Population ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Baseline Levels

Inverse Association between Pulmonary Function and C-Reactive Protein in Apparently Healthy Subjects

2006 ◽  
Vol 174 (6) ◽  
pp. 626-632 ◽  
Author(s):  
Doron Aronson ◽  
Inon Roterman ◽  
Mordechay Yigla ◽  
Arthur Kerner ◽  
Ophir Avizohar ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Healthy Subjects ◽  
Inverse Association ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Apparently Healthy

scholarly journals Distributions of C-reactive Protein Measured by High-Sensitivity Assays in Apparently Healthy Men and Women from Different Populations in Europe

2003 ◽  
Vol 49 (4) ◽  
pp. 669-672 ◽  
Author(s):  
Armin Imhof ◽  
Margit Fröhlich ◽  
Hannelore Loewel ◽  
Nicole Helbecque ◽  
Mark Woodward ◽  
...  
Keyword(s):  
High Sensitivity ◽  
C Reactive Protein ◽  
Men And Women ◽  
Healthy Men ◽  
Reactive Protein ◽  
Different Populations ◽  
Apparently Healthy
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