scholarly journals Direct action of an angiotensin II receptor blocker on angiotensin II-induced left atrial conduction delay in spontaneously hypertensive rats

2009 ◽  
Vol 32 (8) ◽  
pp. 721-726 ◽  
Author(s):  
Narihisa Matsuyama ◽  
Takeshi Tsutsumi ◽  
Nami Kubota ◽  
Toshiaki Nakajima ◽  
Hiroshi Suzuki ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Left Atrial ◽  
Spontaneously Hypertensive Rats ◽  
Direct Action ◽  
Receptor Blocker ◽  
Conduction Delay ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Telmisartan reduces atrial arrhythmia susceptibility through the regulation of RAS–ERK and PI3K–Akt–eNOS pathways in spontaneously hypertensive rats

2015 ◽  
Vol 93 (8) ◽  
pp. 657-665 ◽  
Author(s):  
Wei-wei Wang ◽  
Fei-long Zhang ◽  
Jian-hua Chen ◽  
Xue-hai Chen ◽  
Fa-yuan Fu ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Body Mass ◽  
Spontaneously Hypertensive Rats ◽  
Atrial Arrhythmia ◽  
Atrial Remodeling ◽  
Angiotensin Ii Receptor Blocker ◽  
Angiotensin Ii Receptor ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Ppar Γ

Telmisartan is an angiotensin II receptor blocker that displays unique PPAR-γ modulating activity. PPAR-γ agonists have been shown to decrease susceptibility to atrial fibrillation through their antioxidant and antiapoptotic effects. The aim of this study was to determine whether telmisartan would have a greater effect on susceptibility to atrial arrhythmia in a hypertensive rat model than valsartan, which is a traditional angiotensin II receptor blocker. In this study, spontaneously hypertensive rats were treated with 10 mg·(kg body mass)–1·d–1telmisartan (TEL group), 10 mg·(kg body mass)–1·d–1valsartan (VAL group), or vehicle (saline; SHR group) for 4 weeks. Age-matched Wistar–Kyoto rats (WKY) were used as normotensive controls. After 4 weeks of treatment, we performed echocardiographic assessment, electrophysiological analysis, histological evaluation, and Western blot analysis. Telmisartan decreased systolic blood pressure to a similar extent as valsartan. Relative to the WKY controls, atrial arrhythmia susceptibility was significantly increased in the SHR group, and was significantly decreased by both telmisartan and valsartan, albeit to a greater extent with telmisartan. Arrhythmogenic atrial remodeling, including enlargement of the left atrium, myocyte hypertrophy, interstitial fibrosis, and myocyte apoptosis, was observed in the SHR group, and was accompanied by activated RAS–ERK signaling and suppressed PI3K–Akt–eNOS signaling. The results suggest that telmisartan reduced susceptibility to atrial arrhythmia to a greater extent than valsartan, ameliorated atrial remodeling, and reversed imbalances in the RAS–ERK and PI3K–Akt–eNOS pathways.

scholarly journals Angiotensin II Type 1 Receptor Blocker Reduces Monocyte Adhesion to Endothelial Cells in Spontaneously Hypertensive Rats

2007 ◽  
Vol 54 (4) ◽  
pp. 605-612 ◽  
Author(s):  
Fuki IKEDA ◽  
Kosuke AZUMA ◽  
Takeshi OGIHARA ◽  
Yukiko TOYOFUKU ◽  
Aiko OTSUKA ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Angiotensin Ii ◽  
Spontaneously Hypertensive Rats ◽  
Receptor Blocker ◽  
Monocyte Adhesion ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive
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