scholarly journals Peroxisome proliferator-activated receptor-α activator fenofibrate prevents high-fat diet-induced renal lipotoxicity in spontaneously hypertensive rats

2009 ◽  
Vol 32 (10) ◽  
pp. 835-845 ◽  
Author(s):  
Seok Joon Shin ◽  
Ji Hee Lim ◽  
Sungjin Chung ◽  
Dong-Ye Youn ◽  
Hyun Wha Chung ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Spontaneously Hypertensive Rats ◽  
Peroxisome Proliferator ◽  
High Fat ◽  
Hypertensive Rats ◽  
Peroxisome Proliferator Activated Receptor ◽  
Spontaneously Hypertensive

scholarly journals Endothelial Dysfunction and the Development of Renal Injury in Spontaneously Hypertensive Rats Fed a High-Fat Diet

Hypertension ◽  
2008 ◽  
Vol 51 (2) ◽  
pp. 352-359 ◽  
Author(s):  
Sarah F. Knight ◽  
Jeffrey E. Quigley ◽  
Jianghe Yuan ◽  
Siddhartha S. Roy ◽  
Ahmed Elmarakby ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Renal Injury ◽  
High Fat Diet ◽  
Spontaneously Hypertensive Rats ◽  
High Fat ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Antihypertensive Effect of Radix Paeoniae Alba in Spontaneously Hypertensive Rats and Excessive Alcohol Intake and High Fat Diet Induced Hypertensive Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Chen Su-Hong ◽  
Chen Qi ◽  
Li Bo ◽  
Gao Jian-Li ◽  
Su Jie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Fat Diet ◽  
Spontaneously Hypertensive Rats ◽  
Antihypertensive Effect ◽  
Hdl Cholesterol ◽  
High Fat ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Excessive Alcohol ◽  
Radix Paeoniae Alba

Radix Paeoniae Alba (Baishao, RPA) has long been used in traditional Chinese medicine formulation to treat hypertension by repression the hyperfunction of liver. However, whether the RPA itself has the antihypertensive effect or not is seldom studied. This study was to evaluate the protective effect of RPA on hypertensive rats. Alcohol in conjunction with a high fat diet- (ACHFD-) induced hypertensive rats and spontaneously hypertensive rats (SHR) was constantly received either RPA extract (25 or 75 mg/kg) or captopril (15 mg/kg) all along the experiments. As a result, RPA extract (75 mg/kg) could significantly reduce systolic blood pressure of both ACHFD-induced hypertensive rats and SHR after 9-week or 4-week treatment. In ACHFD-induced hypertensive rats, the blood pressure was significantly increased and the lipid profiles in serum including triglyceride, total cholesterol, LDL-cholesterol, and HDL-cholesterol were significantly deteriorated. Also, hepatic damage was manifested by a significant increase in alanine transaminase (ALT) and aspartate transaminase (AST) in serum. The RPA extract significantly reversed these parameters, which revealed that it could alleviate the liver damage of rats. In SHR, our result suggested that the antihypertensive active of RPA extract may be related to its effect on regulating serum nitric oxide (NO) and endothelin (ET) levels.

scholarly journals Antihypertensive Effects of Peroxisome Proliferator-Activated Receptor-β Activation in Spontaneously Hypertensive Rats

Hypertension ◽  
2011 ◽  
Vol 58 (4) ◽  
pp. 733-743 ◽  
Author(s):  
María José Zarzuelo ◽  
Rosario Jiménez ◽  
Pilar Galindo ◽  
Manuel Sánchez ◽  
Ana Nieto ◽  
...  
Keyword(s):  
Spontaneously Hypertensive Rats ◽  
Peroxisome Proliferator ◽  
Hypertensive Rats ◽  
Peroxisome Proliferator Activated Receptor ◽  
Spontaneously Hypertensive

scholarly journals An experimental model for hypertensive crises emergencies: Long-term high-fat diet followed by acute vasoconstriction stress on spontaneously hypertensive rats

2018 ◽  
Vol 243 (5) ◽  
pp. 481-495
Author(s):  
Hong Liu ◽  
Wei-Wei Su ◽  
Chao-Feng Long ◽  
Wei-Jian Zhang ◽  
Pei-Bo Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Animal Model ◽  
Early Intervention ◽  
High Fat Diet ◽  
Spontaneously Hypertensive Rats ◽  
High Fat ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Hypertensive Crises

Currently, the prevention and treatment of hypertensive crises especially when it occurs with serious adverse outcomes have led to worldwide controversy. Despite of clinical possibilities of multiple agents, clinical failures still occur frequently. Therefore, early evaluations and observations of different therapies on appropriate animals should be emphasized. In the present study, an animal model for hypertensive crises emergencies was firstly established and experimentally testified. Five-month-male spontaneously hypertensive rat was consecutively fed with 60%-Kcal fat diet for four, six, and eight weeks with body weight and blood pressure monitored every two weeks, and then followed by an acute vasoconstriction stress of 5-min ice-bath treatment in the 4-h time interval of two adrenaline injections (0.8 mg/kg). Forty-four biochemical parameters were detected, covering hepatic and renal function, blood glucose and lipid levels, myocardial enzymes and energy metabolisms, blood coagulative and anti-coagulative system, oxidative stress and anti-inflammatory cytokine, blood viscosity, and RAAS system. Six tissues including heart, brain, liver, kidney, coronary arteries, and mesenteries were removed for pathological observations with hematoxylin–eosin staining. As a result, multi-organ dysfunctions in the heart, brain, liver, kidney, vascular endothelium, and blood system were testified in the modeling rats at weeks 6 and 8. In conclusion, severe consequences of this animal model were highly similar to those in hypertensive crises emergencies, which could be further utilized in the early intervention of hypertensive crises emergencies including the possible risk factors control and efficient therapies assessment. Impact statement In the late 90s, numerous reports predicted that 1–2% of hypertensive individuals would undergo hypertensive crises (HPC) and figures reached as high as 7% when no antihypertensive therapies were administrated. Currently, clinical failures appear frequently due to the improper or excessive medication regimen instead of the illness itself. Therefore, early evaluations and observations of HPC on appropriate animal models ahead of patients should be discussed and emphasized more widely. In the present study, an appropriate animal model for HPC emergencies was firstly established, in which the consequences of long-term high-fat diet feeding followed by an acute vasoconstriction stress on the spontaneously hypertensive rats were experimentally testified. The proposed model would have a wide application prospects in early intervention of HPC emergencies including the controls of possible risk factors and assessments of efficient therapies.

scholarly journals Effects of Berberine on Adipose Tissues and Kidney Function in 3T3-L1 Cells and Spontaneously Hypertensive Rats

2015 ◽  
Vol 10 (9) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Aya Kishimoto ◽  
Shi-fen Dong ◽  
Hiroko Negishi ◽  
Naomi Yasui ◽  
Jian-ning Sun ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Renal Injury ◽  
Spontaneously Hypertensive Rats ◽  
Binding Protein ◽  
Peroxisome Proliferator ◽  
Hypertensive Rats ◽  
Adipose Tissues ◽  
Peroxisome Proliferator Activated Receptor ◽  
Spontaneously Hypertensive ◽  
Enhancer Binding Protein

We aimed to investigate the effect of berberine on adipose tissues, as well as its effect on renal injury in 3T3-L1 cells and spontaneously hypertensive rats. 3T3-L1 cells were cultured and treated with berberine (5–20 μM) from days 3 to 8. Berberine added to the cultured medium could significantly down-regulate transcription factors, including CCAAT/enhancer binding protein β, CCAAT/enhancer binding protein α, and peroxisome proliferator-activated receptor γ, and suppress peroxisome proliferator-activated receptor target genes, such as adipocyte fatty acid binding protein and fatty acid synthase, and inhibit 3T3-L1 fibroblast differentiation to adipocytes. Male spontaneously hypertensive rats received either 150 mg/day of berberine or saline orally for 8 weeks. Compared with the control, berberine-treated rats exhibited significant reductions in body weight gain ( p<0.05), as well as retroperitoneal and mesenteric adipose tissues ( p<0.05). Berberine-treated rats significantly decreased urinary albumin excretion, a marker of renal injury ( p<0.05). Long-term treatment with berberine decreased the adipose tissues weight and attenuated renal injury in spontaneously hypertensive rats. Based on these results, berberine has an important role in regulating adipose tissues. These results suggest the protective effect of berberine on metabolic syndrome related diseases, such as renal injury.

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