scholarly journals Domesticated species form a treasure-trove for molecular characterization of Mendelian traits by exploiting the specific genetic structure of these species in across-breed genome wide association studies

Heredity ◽  
2012 ◽  
Vol 109 (1) ◽  
pp. 1-3 ◽  
Author(s):  
H-J Megens ◽  
M A M Groenen
Keyword(s):  
Genetic Structure ◽  
Molecular Characterization ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Treasure Trove ◽  
Genome Wide

scholarly journals Genetic structure of Photosystem II functionality in rice unraveled by GWAS analysis

2020 ◽  
Author(s):  
Juan Manuel Vilas ◽  
Estanislao Burgos ◽  
Maria Lucrecia Puig ◽  
Jose Colazo ◽  
Alberto Livore ◽  
...  
Keyword(s):  
Chlorophyll Fluorescence ◽  
Genetic Structure ◽  
Photosystem Ii ◽  
Association Studies ◽  
Rice Genome ◽  
Genome Wide Association ◽  
World Population ◽  
Genome Wide Association Studies ◽  
Chlorophyll Fluorescence Parameters ◽  
Genome Wide

AbstractRice production is a particularly important crop for the half-world population. Therefore, knowledge about which genes are implicated in the functionality of the Photosystem II, that are still poorly explored could collaborate in the assisted selection of rice improving. In the present study, we applied Genome wide Association Studies of PSII chlorophyll fluorescence under two contrasting environmental conditions in 283 rice accessions highly diverse. A total of 110 significant association SNP-phenotype were observed, and 69 quantitative trait loci identified with a total of 157 genes, of which 38 were highly significant, mapped spread out through rice genome. These underlying regions are enriched in genes related to biotic and abiotic stresses, transcription factors, Calvin cycle, senescence, and grain characters. The correlations analyses PSII chlorophyll fluorescence parameters and some panicle characteristics found here suggest the possibility of developing molecular markers to assist the breeding programs that improve photosynthesis and yield in rice.HighlightThe genetic structure of the Photosystem II functionality in rice was studied by using genome-wide association through chlorophyll fluorescence.

scholarly journals Computational Characterization of Osteoporosis Associated SNPs and Genes Identified by Genome-Wide Association Studies

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0150070 ◽  
Author(s):  
Longjuan Qin ◽  
Yuyong Liu ◽  
Ya Wang ◽  
Guiju Wu ◽  
Jie Chen ◽  
...  
Keyword(s):  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide

scholarly journals Post genome-wide association studies functional characterization of prostate cancer risk loci

BMC Genomics ◽  
2013 ◽  
Vol 14 (Suppl 8) ◽  
pp. S9 ◽  
Author(s):  
Junfeng Jiang ◽  
Weirong Cui ◽  
Wanwipa Vongsangnak ◽  
Guang Hu ◽  
Bairong Shen
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Association Studies ◽  
Functional Characterization ◽  
Prostate Cancer Risk ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide

scholarly journals Discovery, Validation and Characterization of Erbb4 and Nrg1 Haplotypes Using Data from Three Genome-Wide Association Studies of Schizophrenia

PLoS ONE ◽  
2013 ◽  
Vol 8 (1) ◽  
pp. e53042 ◽  
Author(s):  
Zeynep Sena Agim ◽  
Melda Esendal ◽  
Laurent Briollais ◽  
Ozgun Uyan ◽  
Mehran Meschian ◽  
...  
Keyword(s):  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Using Data

scholarly journals Multi-Ethnic Genome-Wide Association Study of Decomposed Cardioelectric Phenotypes Illustrates Strategies to Identify and Characterize Evidence of Shared Genetic Effects for Complex Traits

2020 ◽  
Vol 13 (4) ◽  
Author(s):  
Antoine R. Baldassari ◽  
Colleen M. Sitlani ◽  
Heather M. Highland ◽  
Dan E. Arking ◽  
Steve Buyske ◽  
...  
Keyword(s):  
Qt Interval ◽  
Association Studies ◽  
Genetic Effects ◽  
P Wave ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Single Nucleotide ◽  
Genome Wide ◽  
Shared Genetic

Background: We examined how expanding electrocardiographic trait genome-wide association studies to include ancestrally diverse populations, prioritize more precise phenotypic measures, and evaluate evidence for shared genetic effects enabled the detection and characterization of loci. Methods: We decomposed 10 seconds, 12-lead electrocardiograms from 34 668 multi-ethnic participants (15% Black; 30% Hispanic/Latino) into 6 contiguous, physiologically distinct (P wave, PR segment, QRS interval, ST segment, T wave, and TP segment) and 2 composite, conventional (PR interval and QT interval) interval scale traits and conducted multivariable-adjusted, trait-specific univariate genome-wide association studies using 1000-G imputed single-nucleotide polymorphisms. Evidence of shared genetic effects was evaluated by aggregating meta-analyzed univariate results across the 6 continuous electrocardiographic traits using the combined phenotype adaptive sum of powered scores test. Results: We identified 6 novels ( CD36, PITX2, EMB, ZNF592, YPEL2 , and BC043580 ) and 87 known loci (adaptive sum of powered score test P <5×10 −9 ). Lead single-nucleotide polymorphism rs3211938 at CD36 was common in Blacks (minor allele frequency=10%), near monomorphic in European Americans, and had effects on the QT interval and TP segment that ranked among the largest reported to date for common variants. The other 5 novel loci were observed when evaluating the contiguous but not the composite electrocardiographic traits. Combined phenotype testing did not identify novel electrocardiographic loci unapparent using traditional univariate approaches, although this approach did assist with the characterization of known loci. Conclusions: Despite including one-third as many participants as published electrocardiographic trait genome-wide association studies, our study identified 6 novel loci, emphasizing the importance of ancestral diversity and phenotype resolution in this era of ever-growing genome-wide association studies.

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