scholarly journals Long-term and efficient expression of human β-globin gene in a hematopoietic cell line using a new site-specific integrating non-viral system

Gene Therapy ◽  
2015 ◽  
Vol 22 (8) ◽  
pp. 663-674 ◽  
Author(s):  
K Dormiani ◽  
H Mir Mohammad Sadeghi ◽  
H Sadeghi-Aliabadi ◽  
K Ghaedi ◽  
M Forouzanfar ◽  
...  
Keyword(s):  
Cell Line ◽  
Globin Gene ◽  
Hematopoietic Cell ◽  
Site Specific ◽  
Hematopoietic Cell Line ◽  
Efficient Expression

scholarly journals Tcf7 Is an Important Regulator of the Switch of Self-Renewal and Differentiation in a Multipotential Hematopoietic Cell Line

PLoS Genetics ◽  
2012 ◽  
Vol 8 (3) ◽  
pp. e1002565 ◽  
Author(s):  
Jia Qian Wu ◽  
Montrell Seay ◽  
Vincent P. Schulz ◽  
Manoj Hariharan ◽  
David Tuck ◽  
...  
Keyword(s):  
Cell Line ◽  
Hematopoietic Cell ◽  
Self Renewal ◽  
Hematopoietic Cell Line ◽  
Important Regulator

scholarly journals Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6

Blood ◽  
1992 ◽  
Vol 80 (9) ◽  
pp. 2298-2305 ◽  
Author(s):  
K Oritani ◽  
T Kaisho ◽  
K Nakajima ◽  
T Hirano
Keyword(s):  
Signal Transduction ◽  
Retinoic Acid ◽  
Cell Line ◽  
Interleukin 6 ◽  
Signal Transduction Pathway ◽  
Inhibitory Effect ◽  
Hematopoietic Cell ◽  
Transduction Pathway ◽  
Macrophage Differentiation ◽  
Hematopoietic Cell Line

Abstract We established a radiation-induced murine hematopoietic cell line, Y6, that could be induced to differentiate into macrophages by interleukin- 6 (IL-6). IL-6 also induced growth inhibition and apoptosis in Y6 cells. Retinoic acid (RA) inhibited such effects of IL-6 on Y6 cells. The inhibitory effect of RA on the effects of IL-6 was not caused by the downregulation of the IL-6 receptor, because RA neither affected the expression of IL-6 receptor mRNA nor the expression of IL-6 receptor molecule on the cell surface. Furthermore, RA did not inhibit the IL-6-induced expression of junB mRNA, indicating that the expression of functionally active IL-6 receptor and the signal transduction pathway activating the junB gene are not inhibited by RA. IL-6-induced macrophage differentiation of Y6 cells was preceded by the downregulation of the c-myc gene, which was also prevented by RA. Because the inhibitory effect of RA on Y6 cells was reversible and seemed not to require de novo protein synthesis, the RA receptor by itself might be directly involved in the inhibition of the IL-6 signal transduction pathway. The results indicated that the IL-6 signal transduction pathways leading to the induction of macrophage differentiation and junB gene expression can be dissected by RA.

A novel stromal cell-dependent hematopoietic cell line established from temperature-sensitive SV40 T-antigen transgenic mice

1999 ◽  
Vol 27 (6) ◽  
pp. 1087-1096 ◽  
Author(s):  
Nobuaki Yanai ◽  
Naoko Matsui ◽  
Ken-Ichi Matsuda ◽  
Tadashi Furusawa ◽  
Tadashi Okubo ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Cell Line ◽  
Stromal Cell ◽  
T Antigen ◽  
Hematopoietic Cell ◽  
Temperature Sensitive ◽  
Sv40 T Antigen ◽  
Hematopoietic Cell Line

Identification of a vascular endothelial growth factor (VEGF) antagonist, sFlt-1, from a human hematopoietic cell line NALM-16

FEBS Letters ◽  
2000 ◽  
Vol 469 (1) ◽  
pp. 14-18 ◽  
Author(s):  
Toshiya Inoue ◽  
Keiko Kibata ◽  
Motoyuki Suzuki ◽  
Shuji Nakamura ◽  
Ryuichi Motoda ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Cell Line ◽  
Hematopoietic Cell ◽  
Vascular Endothelial ◽  
Hematopoietic Cell Line ◽  
Endothelial Growth Factor

scholarly journals Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7

Leukemia ◽  
2000 ◽  
Vol 14 (4) ◽  
pp. 662-670 ◽  
Author(s):  
C Issaad ◽  
M Ahmed ◽  
S Novault ◽  
ML Bonnet ◽  
T Bennardo ◽  
...  
Keyword(s):  
Cell Line ◽  
Biological Effects ◽  
Hematopoietic Cell ◽  
Hematopoietic Cell Line
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