scholarly journals Sendai virus-mediated gene transfer of the c-myc suppressor far-upstream element-binding protein-interacting repressor suppresses head and neck cancer

Gene Therapy ◽  
2015 ◽  
Vol 22 (4) ◽  
pp. 297-304 ◽  
Author(s):  
N Tanaka ◽  
K Araki ◽  
D Mizokami ◽  
Y Miyagawa ◽  
T Yamashita ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Gene Transfer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Sendai Virus ◽  
Binding Protein ◽  
Element Binding Protein ◽  
Upstream Element

New Treatment of Head and Neck Cancer by Oncolytic Recombinant Sendai Virus

2016 ◽  
Vol 67 (2) ◽  
pp. 128-128
Author(s):  
Y. Miyagawa ◽  
T. Yamashita ◽  
S. Tanaka ◽  
Y. Tanaka ◽  
M. Tomifuji ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Sendai Virus ◽  
New Treatment

Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer

2015 ◽  
Vol 358 (2) ◽  
pp. 191-199 ◽  
Author(s):  
Babitha George ◽  
Dominik Horn ◽  
Pilar Bayo ◽  
Karim Zaoui ◽  
Christa Flechtenmacher ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cellular Senescence ◽  
Binding Protein ◽  
And Function

scholarly journals Selenium-binding protein 1 in head and neck cancer is low-expression and associates with the prognosis of nasopharyngeal carcinoma

Medicine ◽  
2016 ◽  
Vol 95 (35) ◽  
pp. e4592 ◽  
Author(s):  
Fasheng Chen ◽  
Chen Chen ◽  
Yangang Qu ◽  
Hua Xiang ◽  
Qingxiu Ai ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Nasopharyngeal Carcinoma ◽  
Head And Neck ◽  
Neck Cancer ◽  
Binding Protein ◽  
Low Expression

Fas ligand gene transfer effectively induces apoptosis in head and neck cancer cells

2011 ◽  
Vol 131 (8) ◽  
pp. 876-881 ◽  
Author(s):  
Xiaojun Ji ◽  
Chen Jiang ◽  
Yuhe Liu ◽  
Dingfang Bu ◽  
Shuifang Xiao
Keyword(s):  
Head And Neck Cancer ◽  
Gene Transfer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Fas Ligand

scholarly journals LIM-Only Protein 4 (LMO4) and LIM Domain Binding Protein 1 (LDB1) Promote Growth and Metastasis of Human Head and Neck Cancer (LMO4 and LDB1 in Head and Neck Cancer)

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0164804 ◽  
Author(s):  
Elizabeth A. Simonik ◽  
Ying Cai ◽  
Katherine N. Kimmelshue ◽  
Dana M. Brantley-Sieders ◽  
Holli A. Loomans ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Binding Protein ◽  
Human Head ◽  
Lim Domain

scholarly journals The Role of Interleukin-2 in Combination Adenovirus Gene Therapy for Head and Neck Cancer

1997 ◽  
Vol 11 (6) ◽  
pp. 667-673 ◽  
Author(s):  
Bert W. O’Malley ◽  
Duane A. Sewell ◽  
Daqing Li ◽  
Ken-ichiro Kosai ◽  
Shu-Hsia Chen ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Head And Neck Cancer ◽  
Gene Transfer ◽  
Head And Neck ◽  
Cell Line ◽  
Neck Cancer ◽  
Interleukin 2 ◽  
Separate Experiment ◽  
Microscopic Evaluation ◽  
Parental Tumor

Abstract Interleukin-2 (IL-2) gene therapy alone and in combination with the herpes thymidine kinase gene (tk) was used to evaluate immunological responses and antitumor effects in head and neck cancer. Established floor of mouth squamous cell carcinomas in C3H/HeJ mice were directly injected with recombinant adenoviral vectors carrying both therapeutic and control genes. One week after adenoviral gene transfer, only the animals treated with combination IL-2+tk or tk alone demonstrated significant tumor regression. Residual tumors were harvested for microscopic evaluation and immunohistochemistry staining, which revealed a predominance of CD8+ lymphocytes in the tumor beds of the animals treated with IL-2. To evaluate the systemic immune effects of IL-2, animals treated with single or combination gene therapy received a second site challenge with parental tumor cells or a heterologous but syngeneic sarcoma cell line. Mice treated with combination IL-2 and tk demonstrated a protective systemic immunity specific to the parental tumor cell line, whereas no systemic immune response was evident in mice receiving IL-2 alone. In a separate experiment, a range of concentrations of the adenovirus IL-2 vector were used to treat established tumors. Even with the maximal single-dose adenovirus concentration, IL-2 alone was ineffective as a single therapy. These results support the use of adenovirus-mediated gene transfer of IL-2 as an effective immunotherapy when used adjuvantly with the tk “suicide gene”.

scholarly journals Expression of Y-box-binding protein YB-1 allows stratification into long- and short-term survivors of head and neck cancer patients

2011 ◽  
Vol 105 (12) ◽  
pp. 1864-1873 ◽  
Author(s):  
A Kolk ◽  
N Jubitz ◽  
K Mengele ◽  
K Mantwill ◽  
O Bissinger ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Binding Protein ◽  
Short Term

scholarly journals Gene Transfer into Head and Neck Cancer by Pulsed Laser

2010 ◽  
Vol 143 (2_suppl) ◽  
pp. P61-P61
Author(s):  
Koji Araki ◽  
Takuya Akiyama ◽  
Mitsuhiro Terakawa ◽  
Sato Shunichi ◽  
Akihiro Shiotani
Keyword(s):  
Head And Neck Cancer ◽  
Gene Transfer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Pulsed Laser

scholarly journals Expression of Fibroblast Growth Factor Binding Protein in Head and Neck Cancer

2009 ◽  
Vol 135 (9) ◽  
pp. 896 ◽  
Author(s):  
Weimin Li ◽  
Chuan Wang ◽  
Steven K. Juhn ◽  
Frank G. Ondrey ◽  
Jizhen Lin
Keyword(s):  
Head And Neck Cancer ◽  
Growth Factor ◽  
Head And Neck ◽  
Fibroblast Growth Factor ◽  
Neck Cancer ◽  
Binding Protein ◽  
Fibroblast Growth ◽  
Factor Binding
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