scholarly journals Erratum: Gene therapy approach to FAP: in vivo influence of T119M in TTR deposition in a transgenic V30M mouse model

Gene Therapy ◽  
2014 ◽  
Vol 21 (12) ◽  
pp. 1065-1065 ◽  
Author(s):  
A R Batista ◽  
D Gianni ◽  
M Ventosa ◽  
A V Coelho ◽  
M R Almeida ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Therapy Approach ◽  
Gene Therapy Approach

scholarly journals Gene therapy approach to FAP: in vivo influence of T119M in TTR deposition in a transgenic V30M mouse model

Gene Therapy ◽  
2014 ◽  
Vol 21 (12) ◽  
pp. 1041-1050 ◽  
Author(s):  
A R Batista ◽  
D Gianni ◽  
M Ventosa ◽  
A V Coelho ◽  
M R Almeida ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Therapy Approach ◽  
Gene Therapy Approach

A Gene Therapy Approach to Improve Copper Metabolism and Prevent Liver Damage in a Mouse Model of Wilson Disease

2019 ◽  
Vol 30 (1) ◽  
pp. 29-39 ◽  
Author(s):  
Jenny A. Greig ◽  
Jayme M. L. Nordin ◽  
Melanie K. Smith ◽  
Scott N. Ashley ◽  
Christine Draper ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Liver Damage ◽  
Wilson Disease ◽  
Copper Metabolism ◽  
Therapy Approach ◽  
Gene Therapy Approach

A Cancer Gene Therapy Approach that Targets Tumor-associated Hyaluronan

2009 ◽  
Vol 2 ◽  
pp. CGM.S3716 ◽  
Author(s):  
Shona T. Dougherty ◽  
Graeme J. Dougherty
Keyword(s):  
Gene Therapy ◽  
Malignant Disease ◽  
Chimeric Proteins ◽  
Death Domain ◽  
Therapy Approach ◽  
Gene Therapy Approach ◽  
Apoptotic Protein ◽  
Clonogenic Potential ◽  
Target Gene Therapy

The extracellular matrix glycosaminoglycan hyaluronan plays a key role in the development and pathogenesis of malignant disease. Reflecting its functional importance, the molecule is expressed at greatly elevated levels within many solid tumors. Although little explored, differences in the level of hyaluronan present in normal and malignant tissues could potentially be exploited to more effectively target gene therapy to tumor sites in vivo. As a first step toward this goal, we describe here a family of chimeric proteins in which the extracellular ligand-binding domain of the hyaluronan receptor CD44 is fused in-frame to the cytoplasmic “death domain” of the pro-apoptotic protein Fas. Although these chimeric proteins can be stably expressed on the surface of transduced tumor cells in the absence of hyaluronan, upon interaction with the ligand, apoptosis is rapidly induced. Both exogenous and endogenous tumor produced hyaluronan can function as triggers, dramatically reducing clonogenic potential. Together, these studies help validate a broadly applicable gene therapy approach in which the presence of particular multivalent ligands within the tumor microenvironment can be exploited for therapeutic gain.

scholarly journals 54. Prevention of Sensory Ataxia in a Novel Mouse Model of Friedreich Ataxia Using Gene Therapy Approach

2016 ◽  
Vol 24 ◽  
pp. S24
Author(s):  
Françoise Piguet ◽  
Charline de Montigny ◽  
Nadège Vaucamps ◽  
Laurence Reutenauer ◽  
Hélène Puccio
Keyword(s):  
Gene Therapy ◽  
Mouse Model ◽  
Friedreich Ataxia ◽  
Therapy Approach ◽  
Gene Therapy Approach ◽  
Sensory Ataxia

scholarly journals CD163 overexpression using a macrophage-directed gene therapy approach improves wound healing in ex vivo and in vivo human skin models

Immunobiology ◽  
2020 ◽  
Vol 225 (1) ◽  
pp. 151862
Author(s):  
David Wilson Ferreira ◽  
Cristina Ulecia-Morón ◽  
Perla Abigail Alvarado-Vázquez ◽  
Katharine Cunnane ◽  
Carolina Moracho-Vilriales ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Wound Healing ◽  
Human Skin ◽  
Ex Vivo ◽  
Therapy Approach ◽  
Gene Therapy Approach ◽  
Human Skin Models
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