scholarly journals Interleukin-6 small interfering RNA improved the herpes simplex virus-induced systemic inflammation in vivo Behcet’s disease-like mouse model

Gene Therapy ◽  
2008 ◽  
Vol 16 (3) ◽  
pp. 415-425 ◽  
Author(s):  
J Shim ◽  
H O Byun ◽  
Y D Lee ◽  
E S Lee ◽  
S Sohn
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Mouse Model ◽  
Systemic Inflammation ◽  
Interleukin 6 ◽  
Small Interfering Rna ◽  
Behcet’S Disease ◽  
Simplex Virus ◽  
Interfering Rna

scholarly journals Use of herpes simplex virus type 1-based amplicon vector for delivery of small interfering RNA

Gene Therapy ◽  
2006 ◽  
Vol 14 (5) ◽  
pp. 459-464 ◽  
Author(s):  
S Sabbioni ◽  
E Callegari ◽  
M Manservigi ◽  
R Argnani ◽  
A Corallini ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Small Interfering Rna ◽  
Simplex Virus ◽  
Interfering Rna

scholarly journals Innate responses to small interfering RNA pools inhibiting herpes simplex virus infection in astrocytoid and epithelial cells

2014 ◽  
Vol 21 (4) ◽  
pp. 349-357 ◽  
Author(s):  
Henrik Paavilainen ◽  
Alesia Romanovskaya ◽  
Michaela Nygårdas ◽  
Dennis H Bamford ◽  
Minna M Poranen ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Epithelial Cells ◽  
Virus Infection ◽  
Small Interfering Rna ◽  
Herpes Simplex Virus Infection ◽  
Simplex Virus ◽  
Interfering Rna

scholarly journals The Role of T Cell Immunoglobulin Mucin Domains 1 and 4 in a Herpes Simplex Virus-Induced Behçet’s Disease Mouse Model

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Ju A. Shim ◽  
Eun-So Lee ◽  
Bunsoon Choi ◽  
Seonghyang Sohn
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
T Cell ◽  
Mouse Model ◽  
Behçet’S Disease ◽  
Severity Score ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Simplex Virus

The T cell immunoglobulin mucin (TIM) proteins regulate T cell activation and tolerance. TIM-1 plays an important role in the regulation of immune responses and the development of autoimmune diseases. TIM-4 is a natural ligand of TIM-1, and the interaction of TIM-1 and TIM-4 is involved in the regulation of T helper (Th) cell responses and modulation of the Th1/Th2 cytokine balance. Behçet’s disease (BD) is a chronic, multisystemic inflammatory disorder with arthritic, intestinal, mucocutaneous, ocular, vascular, and central nervous system involvement. Tim-1 expression was lower in a herpes simplex virus-induced BD mouse model compared to that in asymptomatic BD normal (BDN) mice. Tim-4 expression was higher in BD mice than that in BDN mice. In this study, we investigated the Tim expression in a BD mouse model with BD-like symptoms. Tim-1 and Tim-4 expression was regulated by an expression vector or siRNA injected into the BD mouse model. TheTim-1vector injected into BD mice resulted in changes in BD-like symptoms and decreased the severity score. Treatment with Tim-4 siRNA also improved BD-like symptoms and decreased the severity score accompanied by upregulation of regulatory T cells. We showed that regulating Tim-1 or Tim-4 affected BD-like symptoms in mice.

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