scholarly journals Evaluation of safety and efficacy of RNAi against HIV-1 in the human immune system (Rag-2-/-γc-/-) mouse model

Gene Therapy ◽  
2008 ◽  
Vol 16 (1) ◽  
pp. 148-153 ◽  
Author(s):  
O ter Brake ◽  
N Legrand ◽  
K J von Eije ◽  
M Centlivre ◽  
H Spits ◽  
...  
Keyword(s):  
Immune System ◽  
Mouse Model ◽  
Human Immune System ◽  
Safety And Efficacy ◽  
Human Immune ◽  
Hiv 1

scholarly journals P06.07 In vivo studies of immunomodulatory a-CTLA-4 antibody in a humanized mouse model

2021 ◽  
Vol 9 (Suppl 1) ◽  
pp. A22.1-A22
Author(s):  
C Reitinger ◽  
F Nimmerjahn
Keyword(s):  
Immune System ◽  
Mouse Model ◽  
Cancer Immunotherapy ◽  
Model Systems ◽  
Checkpoint Control ◽  
Human Immune System ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Human Immune

BackgroundRecent findings in cancer immunotherapy have reinforced the hypothesis that the immune system is able to control most cancers. Immunomodulatory antibodies can enhance immune responses, having the potential to generate anti-cancer immunity.1–4Materials and MethodsMost current studies addressing this question are performed in murine mouse model systems or use in vitro culture systems, which do not reflect the human in vivo situation, potentially leading to results that cannot be fully translated into human cancer therapy. Therefore, it is necessary to establish a new mouse model, which allows the study of cancer immunotherapy in the context of a human immune system. We focused on the establishment of a humanized mouse model, in which different immunomodulatory antibodies can be tested in the presence of a human immune system.ResultsFirst experiments concerning the suitability to test immunomodulatory antibodies in the humanized mouse model, revealed that effects of checkpoint-control antibody a-CTLA-4 were similar to the effects seen in patients of clinical studies. To analyse the anti-tumor activities of immunomodulatory antibodies in vivo we are establishing a human melanoma-like tumor model in humanized mice.ConclusionsThis enables us to test the efficacy of immunomodulatory agonistic antibodies (such as CP-870,893) and checkpoint control antibodies (such as anti-CTLA-4) in eliminating a melanoma-like tumor. Furthermore, parameters like tumor infiltrating human cells und cytokine/chemokine production can be analysed.ReferencesSchuster M, Nechansky A, Loibner H. Cancer immunotherapy. Biotechnol J 2006;1:138–147.Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature rev 2011;480:480–489.Finn OJ. Immuno-oncology: understanding the function and dysfunction of the immune system in cancer. Annals of Oncology 2012;23:vii6–vii9.Langer LF, Clay TM, Morse MA. Update on anti-CTLA-4 in clinical trials. Expert Opin Biol Ther 2007;8:1245–1256.Disclosure InformationC. Reitinger: None. F. Nimmerjahn: None.

scholarly journals OA06-05. Adaptation of HIV-1 to the human immune system at the population level is driven by protective HLA-B alleles

Retrovirology ◽  
2009 ◽  
Vol 6 (S3) ◽  
Author(s):  
IM Schellens ◽  
M Navis ◽  
HW van Deutekom ◽  
B Boeser-Nunnink ◽  
B Berkhout ◽  
...  
Keyword(s):  
Immune System ◽  
Population Level ◽  
Human Immune System ◽  
Human Immune ◽  
Hiv 1

A human immune system mouse model with robust lymph node development

2018 ◽  
Vol 15 (8) ◽  
pp. 623-630 ◽  
Author(s):  
Yan Li ◽  
Guillemette Masse-Ranson ◽  
Zacarias Garcia ◽  
Timothée Bruel ◽  
Ayrin Kök ◽  
...  
Keyword(s):  
Lymph Node ◽  
Immune System ◽  
Mouse Model ◽  
Human Immune System ◽  
Human Immune ◽  
Node Development

scholarly journals Generation of a humanized mouse model with both human immune system and liver cells to model hepatitis C virus infection and liver immunopathogenesis

2012 ◽  
Vol 7 (9) ◽  
pp. 1608-1617 ◽  
Author(s):  
Moses T Bility ◽  
Liguo Zhang ◽  
Michael L Washburn ◽  
T Anthony Curtis ◽  
Grigoriy I Kovalev ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Immune System ◽  
Hepatitis C ◽  
Virus Infection ◽  
Mouse Model ◽  
Hepatitis C Virus Infection ◽  
Human Immune System ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Human Immune

scholarly journals Molecular mimicry of HIV gp120: Possible implications on prevention and therapy of AIDS

2005 ◽  
Vol 13 (3-4) ◽  
pp. 126-130
Author(s):  
Nevena Veljkovic
Keyword(s):  
Immune System ◽  
Immune Responses ◽  
Molecular Mimicry ◽  
Human Immune System ◽  
Host Cell Proteins ◽  
Immunodeficiency Virus ◽  
Human Proteins ◽  
Human Immune ◽  
Hiv Gp120 ◽  
Hiv 1

A broad range of similarities between HIV-1 gp120 and human proteins-especially those participating in immune responses-highlight gp120 as a pleiotropic protein which can influence many important functions of the human immune system. The molecular mimicry that serves to the human immunodeficiency virus as potent destructive arms against immune system could be the weak point we are in search of over decades. Examples involving sequence and informational similarities of HIV-1 gp120 and immunerelated host cell proteins important for prevention and treatment of HIV infection are presented. .

scholarly journals A Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO.IL-2Rγc KO. NOD) for COVID-19

2021 ◽  
Author(s):  
Teodor-Doru Brumeanu ◽  
Pooja Vir ◽  
Ahmad Faisal Karim ◽  
Swagata Kar ◽  
Dalia Benetiene ◽  
...  
Keyword(s):  
Immune System ◽  
T Cell ◽  
Mouse Model ◽  
Human Model ◽  
Human Immune System ◽  
Humanized Mouse ◽  
Humanized Mouse Model ◽  
Human Cord Blood ◽  
Hematopoietic Stem ◽  
Human Immune

Abstract We report the first Human Immune System (HIS)-humanized mouse model (“DRAGA”: HLA-A2.HLA-DR4.Rag1KO.IL-2RgcKO.NOD) for COVID-19 research. This mouse is reconstituted with human cord blood-derived, HLA-matched hematopoietic stem cells. It engrafts human epi/endothelial cells expressing the human ACE2 receptor for SARS-CoV-2 and TMPRSS2 serine protease co-localized on lung epithelia. HIS-DRAGA mice sustained SARS-CoV-2 infection, showing deteriorated clinical condition, replicating virus in the lungs, and human-like lung immunopathology including T-cell infiltrates, microthrombi and pulmonary sequelae. Among T-cell infiltrates, lung-resident (CD103+) CD8+ T cells were sequestered in epithelial (CD326+) lung niches and secreted granzyme B and perforin, indicating cytotoxic potential. Infected mice also developed antibodies against the SARS-CoV-2 viral proteins. Hence, HIS-DRAGA mice showed unique advantages as a surrogate in vivo human model for studying SARS-CoV-2 immunopathology and for testing the safety and efficacy of candidate vaccines and therapeutics.

scholarly journals A Novel Mouse Model for Stable Engraftment of a Human Immune System and Human Hepatocytes

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119820 ◽  
Author(s):  
Helene Strick-Marchand ◽  
Mathilde Dusséaux ◽  
Sylvie Darche ◽  
Nicholas D. Huntington ◽  
Nicolas Legrand ◽  
...  
Keyword(s):  
Immune System ◽  
Mouse Model ◽  
Human Hepatocytes ◽  
Human Immune System ◽  
Human Immune
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