scholarly journals Clinical and genetic heterogeneity in a large cohort of Armenian patients with late-onset familial Mediterranean fever

2018 ◽  
Vol 20 (12) ◽  
pp. 1583-1588 ◽  
Author(s):  
Gernot Kriegshäuser ◽  
Dietmar Enko ◽  
Hasmik Hayrapetyan ◽  
Stepan Atoyan ◽  
Christian Oberkanins ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Genetic Heterogeneity ◽  
Late Onset ◽  
Large Cohort ◽  
Mediterranean Fever

Late-onset familial Mediterranean fever in Japan

2019 ◽  
Vol 30 (3) ◽  
pp. 564-567 ◽  
Author(s):  
Dai Kishida ◽  
Masahide Yazaki ◽  
Akinori Nakamura ◽  
Ayako Tsuchiya-Suzuki ◽  
Yasuhiro Shimojima ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Late Onset ◽  
Mediterranean Fever

Late onset of Crohn's disease in familial Mediterranean fever: The necessity of anti-TNF treatment

2014 ◽  
Vol 15 (2) ◽  
pp. 102-104 ◽  
Author(s):  
Maria Kosmidou ◽  
Vasileios Mpolotsis ◽  
Leonidas Christou ◽  
Epameinondas V Tsianos
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Familial Mediterranean Fever ◽  
Late Onset ◽  
Mediterranean Fever

Late-onset disease is associated with a mild phenotype in children with familial Mediterranean fever

2016 ◽  
Vol 35 (7) ◽  
pp. 1837-1840 ◽  
Author(s):  
Semanur Özdel ◽  
Z.Birsin Özçakar ◽  
Seda Şahin Kunt ◽  
Atilla H. Elhan ◽  
Fatoş Yalçınkaya
Keyword(s):  
Familial Mediterranean Fever ◽  
Late Onset ◽  
Mild Phenotype ◽  
Mediterranean Fever

MEFV alterations and population genetics analysis in a large cohort of Greek patients with familial Mediterranean fever

2007 ◽  
Vol 71 (5) ◽  
pp. 458-467 ◽  
Author(s):  
S Giaglis ◽  
V Papadopoulos ◽  
K Kambas ◽  
M Doumas ◽  
V Tsironidou ◽  
...  
Keyword(s):  
Population Genetics ◽  
Familial Mediterranean Fever ◽  
Large Cohort ◽  
Mediterranean Fever

scholarly journals Familial Mediterranean fever in the ‘Chuetas’ of Mallorca: a question of Jewish origin or genetic heterogeneity

2000 ◽  
Vol 8 (4) ◽  
pp. 242-246 ◽  
Author(s):  
Cecile Domingo ◽  
Isabelle Touitou ◽  
Anne Bayou ◽  
Seza Ozen ◽  
Cecile Notarnicola ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Genetic Heterogeneity ◽  
Jewish Origin ◽  
Mediterranean Fever

Comparison of early versus late onset familial Mediterranean fever

2018 ◽  
Vol 21 (4) ◽  
pp. 880-884 ◽  
Author(s):  
Nazife Sule Yasar Bilge ◽  
Ismail Sari ◽  
Dilek Solmaz ◽  
Soner Senel ◽  
Hakan Emmungil ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Late Onset ◽  
Mediterranean Fever

Late-Onset Famılıal Medıterranean Fever: Sıngle-Center Experıence And Lıterature Revıew

2020 ◽  
Author(s):  
Okan Aydin ◽  
Bugra Han Egeli ◽  
Huri Ozdogan ◽  
Serdal Ugurlu
Keyword(s):  
Familial Mediterranean Fever ◽  
Mutation Frequency ◽  
Late Onset ◽  
Disease Onset ◽  
Exon 2 ◽  
M694v Mutation ◽  
Significant Difference ◽  
Mediterranean Fever ◽  
Group 2 ◽  
Group 1

Abstract Introduction: Familial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by recurrent fever and serositis attacks. The disease onset occurs before 20 years of age in 90% of patients. Rarely, the disease onset occurs after 40 years of age. Aim: We aimed to compare the patients with early and late-onset of disease. Methods: We did a retrospective analysis of 2020 patients registered in our FMF center in the years 2008-2017. Patients with disease onset after the age of 40 (Group 1) were collected. The control group (Group 2), disease onset before the age of 20, was randomly selected with twice amount of the study group. Demographic, clinical and genetic data were recorded. Results: Out of 2020 patients, 41 were in group 1 (2.02%). The male to female ratio was 1:1.7 in both groups. The delay of diagnosis was 5.6±5.75 years in group 1, 10.7±12.3 years in group 2. In terms of clinical features, the only significant difference between two groups belonged to fever seen in 26 (63.4%) patients in group 1 and 67 (81.7%) patients in group 2 (p=0,026). M694V mutation frequency was higher in group 2 whereas exon 2 mutation frequency was higher in group 1. The mean colchicine dose in the 6 months was 1.38±0.64 mg in group 1, 1.61±0.47 mg in group 2. Discussion: In patients with late disease onset, the results of decreased mean colchicine dose during the last 6 months, decreased fever ratio, and increased exon 2 mutation frequency might point out to mild disease severity. Keywords: Familial Mediterranean Fever, late-onset, early-onset, MEFV mutation, colchicine

scholarly journals Prevalence of MEFV gene mutations in a large cohort of patients with suspected familial Mediterranean fever in Central Anatolia

2019 ◽  
Vol 39 (6) ◽  
pp. 382-387 ◽  
Author(s):  
Malik Ejder Yildirim ◽  
Hande Kucuk Kurtulgan ◽  
Ozturk Ozdemir ◽  
Hasan Kilicgun ◽  
Didem S. Aydemir ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Mefv Gene ◽  
Gene Mutations ◽  
Large Cohort ◽  
Central Anatolia ◽  
Mediterranean Fever
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