scholarly journals Which BRCA genetic testing programs are ready for implementation in health care? A systematic review of economic evaluations

2016 ◽  
Vol 18 (12) ◽  
pp. 1171-1180 ◽  
Author(s):  
Elvira D’Andrea ◽  
Carolina Marzuillo ◽  
Corrado De Vito ◽  
Marco Di Marco ◽  
Erica Pitini ◽  
...  
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Genetic Testing ◽  
Economic Evaluations ◽  
Brca Genetic Testing

scholarly journals Comparison of (Partial) economic evaluations of transforaminal lumbar interbody fusion (TLIF) versus Posterior lumbar interbody fusion (PLIF) in adults with lumbar spondylolisthesis: A systematic review

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0245963
Author(s):  
Inge J. M. H. Caelers ◽  
Suzanne L. de Kunder ◽  
Kim Rijkers ◽  
Wouter L. W. van Hemert ◽  
Rob A. de Bie ◽  
...  
Keyword(s):  
Systematic Review ◽  
Health Care ◽  
Cost Effectiveness ◽  
Interbody Fusion ◽  
Posterior Lumbar Interbody Fusion ◽  
Transforaminal Lumbar Interbody Fusion ◽  
Economic Evaluations ◽  
Lumbar Interbody Fusion ◽  
Lumbar Spondylolisthesis

Introduction The demand for spinal fusion surgery has increased over the last decades. Health care providers should take costs and cost-effectiveness of these surgeries into account. Open transforaminal lumbar interbody fusion (TLIF) and posterior lumbar interbody fusion (PLIF) are two widely used techniques for spinal fusion. Earlier research revealed that TLIF is associated with less blood loss, shorter surgical time and sometimes shorter length of hospital stay, while effectiveness of both techniques on back and/or leg pain are equal. Therefore, TLIF could result in lower costs and be more cost-effective than PLIF. This is the first systematic review comparing direct and indirect (partial) economic evaluations of TLIF with PLIF in adults with lumbar spondylolisthesis. Furthermore, methodological quality of included studies was assessed. Methods Searches were conducted in eight databases for reporting on eligibility criteria; TLIF or PLIF, lumbar spondylolisthesis or lumbar instability, and cost. Costs were converted to United States Dollars with reference year 2020. Study quality was assessed using the bias assessment tool of the Cochrane Handbook for Systematic Reviews of Interventions, the Level of Evidence guidelines of the Oxford Centre for Evidence-based Medicine and the Consensus Health Economic Criteria (CHEC) list. Results Of a total of 693 studies, 16 studies were included. Comparison of TLIF and PLIF could only be made indirectly, since no study compared TLIF and PLIF directly. There was a large heterogeneity in health care and societal perspective costs due to different in-, and exclusion criteria, baseline characteristics and the use of costs or charges in calculations. Health care perspective costs, calculated with hospital costs, ranged from $15,867-$43,217 in TLIF-studies and $32,662 in one PLIF-study. Calculated with hospital charges, it ranged from $8,964-$51,469 in TLIF-studies and $21,838-$93,609 in two PLIF-studies. Societal perspective costs and cost-effectiveness, only mentioned in TLIF-studies, ranged from $5,702/QALY-$48,538/QALY and $50,092/QALY-$90,977/QALY, respectively. Overall quality of studies was low. Conclusions This systematic review shows that TLIF and PLIF are expensive techniques. Moreover, firm conclusions about the preferable technique, based on (partial) economic evaluations, cannot be drawn due to limited studies and heterogeneity. Randomized prospective trials and full economical evaluations with direct TLIF and PLIF comparison are needed to obtain high levels of evidence. Furthermore, development of guidelines to perform adequate economic evaluations, specified for the field of interest, will be useful to minimize heterogeneity and maximize transferability of results. Trial registration Prospero-database registration number: CRD42020196869.

scholarly journals PMD86 A Systematic Review of Economic Evaluations Conducted for Assessment of Genetic Testing Technologies

2011 ◽  
Vol 14 (7) ◽  
pp. A260
Author(s):  
N. Assasi ◽  
L. Schwartz ◽  
J.E. Tarride ◽  
R. Goeree ◽  
F. Xie
Keyword(s):  
Systematic Review ◽  
Genetic Testing ◽  
Economic Evaluations

scholarly journals PMC2 A SYSTEMATIC REVIEW OF ECONOMIC EVALUATIONS OF GENETIC TESTING TECHNOLOGIES

2005 ◽  
Vol 8 (3) ◽  
pp. 375
Author(s):  
S Ramsey ◽  
N Henrikson ◽  
J Carlson ◽  
DL Veenstra
Keyword(s):  
Systematic Review ◽  
Genetic Testing ◽  
Economic Evaluations

Economic Evaluations Conducted for Assessment of Genetic Testing Technologies: A Systematic Review

2012 ◽  
Vol 16 (11) ◽  
pp. 1322-1335 ◽  
Author(s):  
Nazila Assasi ◽  
Lisa Schwartz ◽  
Jean-Eric Tarride ◽  
Ron Goeree ◽  
Feng Xie
Keyword(s):  
Systematic Review ◽  
Genetic Testing ◽  
Economic Evaluations
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