My46: a Web-based tool for self-guided management of genomic test results in research and clinical settings

ABSTRACTThe McDonald–Kreitman (MK) test is a widely used method for quantifying the role of positive selection in molecular evolution. One key shortcoming of this test lies in its sensitivity to the presence of slightly deleterious mutations, which can severely bias its estimates. An asymptotic version of the MK test was recently introduced that addresses this problem by evaluating polymorphism levels for different mutation frequencies separately, and then extrapolating a function fitted to that data. Here we present asymptoticMK, a web-based implementation of this asymptotic McDonald–Kreitman test. Our web service provides a simple R-based interface into which the user can upload the required data (polymorphism and divergence data for the genomic test region and a neutrally evolving reference region). The web service then analyzes the data and provides plots of the test results. This service is free to use, open-source, and available at http://benhaller.com/messerlab/asymptoticMK.html.

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Genomic Test Results and the Courtroom: The Roles of Experts and Expert Testimony

The Journal of Law Medicine & Ethics ◽

10.1177/1073110516644211 ◽

2016 ◽

Vol 44 (1) ◽

pp. 205-215

Author(s):

Edward Ramos ◽

Shawneequa L. Callier ◽

Peter B. Swann ◽

Hosea H. Harvey

Keyword(s):

Expert Testimony ◽

Single Gene ◽

Duty Of Care ◽

Complex Nature ◽

Clinical Settings ◽

Test Results ◽

Genomic Information ◽

The Public ◽

Genomic Test ◽

Gene Testing

The rapid advancement from single-gene testing to whole genome sequencing has significantly broadened the type and amount of information available to researchers, physicians, patients, and the public in general. Much debate has ensued about whether genomic test results should be reported to research participants, patients and consumers, and at what stage we can be sure that existing evidence justifies their use in clinical settings. Courts and judges evaluating the utility of these results will not be immune to this uncertainty. As scholars increasingly explore the duty of care standards related to reporting genomic test results, it is timely to provide a framework for understanding how uncertainty about genetic and genomic tests influences evidentiary considerations in the court room. Here, we explore the subtleties and nuances of interpreting genetic data in an environment of substantial discord related to the value that individuals should place on genetic and genomic tests. In conjunction, we discuss the roles courts should play in qualifying experts, expert testimony, and genetic and genomic tests given the intricate and complex nature of genetic and genomic information.

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Development of a Web-Based Query Tool for Quality Assurance of Clinical Molecular Genetic Test Results

Journal of Molecular Diagnostics ◽

10.2353/jmoldx.2007.060107 ◽

2007 ◽

Vol 9 (1) ◽

pp. 95-98 ◽

Cited By ~ 3

Author(s):

Matthew J. McGinniss ◽

Rebecca Chen ◽

Victoria M. Pratt ◽

Arlene Buller ◽

Franklin Quan ◽

...

Keyword(s):

Quality Assurance ◽

Genetic Test ◽

Molecular Genetic ◽

Test Results ◽

Web Based ◽

Genetic Test Results ◽

Query Tool ◽

Molecular Genetic Test

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Implementasi Metode Unsupervised Learning Pada Sistem Keamanan Dengan Optimalisasi Penyimpanan Kamera IP

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) ◽

10.29207/resti.v5i6.3552 ◽

2021 ◽

Vol 5 (6) ◽

pp. 1099-1105

Author(s):

Desta Yolanda ◽

Mohammad Hafiz Hersyah ◽

Eno Marozi

Keyword(s):

Unsupervised Learning ◽

Night Vision ◽

Raspberry Pi ◽

Monitoring Systems ◽

Test Results ◽

Storage Process ◽

File Size ◽

Web Based ◽

Security Monitoring ◽

Human Faces

Security monitoring systems using face recognition can be applied to CCTV or IP cameras. This is intended to improve the security system and make it easier for users to track criminals is theft. The experiment was carried out by detecting human faces for 24 hours using different cameras, namely an HD camera that was active during the day and a Night Vision camera that was active at night. The application of Unsupervised Learning method with the concept of an image cluster, aims to distinguish the faces of known or unknown people according to the dataset built in the Raspberry Pi 4. The user interface media of this system is a web-based application built with Python Flask and Python MySQL. This application can be accessed using the domain provided by the IP Forwarding device which can be accessed anywhere. According to the test results on optimization of storage, the system is able to save files only when a face is detected with an average file size of ± 2.28 MB for 1x24 hours of streaming. So that this storage process becomes more efficient and economical compared to the storage process for CCTV or IP cameras in general.

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Multilevel Influences on Patient-Oncologist Communication about Genomic Test Results: Oncologist Perspectives

Journal of Health Communication ◽

10.1080/10810730.2018.1506836 ◽

2018 ◽

Vol 23 (7) ◽

pp. 679-686

Author(s):

Suzanne C. O’Neill ◽

Kathryn L. Taylor ◽

Jonathan Clapp ◽

Jinani Jayasekera ◽

Claudine Isaacs ◽

...

Keyword(s):

Test Results ◽

Genomic Test

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SISTEM INFORMASI PENILAIAN PROPOSAL SKRIPSI BERBASIS WEB DI FAKULTAS TEKNOLOGI INFORMASI UNIVERSITAS ISLAM KALIMANTAN MUHAMMMAD ARSYAD AL BANJARI BANJARMASIN

INFO-TEKNIK ◽

10.20527/infotek.v21i1.8962 ◽

2020 ◽

Vol 21 (1) ◽

pp. 35

Author(s):

Silvia Ratna

Keyword(s):

Information Technology ◽

Information System ◽

Evaluation Process ◽

Test Results ◽

Web Based ◽

Research Implementation ◽

Final Project ◽

Evaluation Information

Implementation of the final project or thesis for students is a tiered process and bound to one another. Starting from the stage of proposal submission, proposal presentation, research implementation, report making up to thesis examination students. At present, the implementation of the thesis trial evaluation at the Information Technology Faculty of the Islamic University of Kalimantan Muhammad Arsyad Al Banjari Banjarmasin is still manual, where when the presentation of proposals and panelists thesis examinations or examiners are given an assessment form using paper media. This assessment form is then recapitulated into a spreadsheet form the results are announced to students. This is less effective, especially when many students take thesis courses. For this reason, in this study, a thesis evaluation information system was created, to help all stages of the thesis evaluation process. To facilitate the accessibility of the system made web-based and integrated with existing academic systems. From the test results concluded, the system can run by the design and reports produced by the system following the processes that are running now.

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Understanding the Return of Genomic Sequencing Results Process: Content Review of Participant Summary Letters in the eMERGE Research Network

Journal of Personalized Medicine ◽

10.3390/jpm10020038 ◽

2020 ◽

Vol 10 (2) ◽

pp. 38 ◽

Cited By ~ 2

Author(s):

John Lynch ◽

Richard Sharp ◽

Sharon Aufox ◽

Sarah Bland ◽

Carrie Blout ◽

...

Keyword(s):

Medical Records ◽

Reading Level ◽

Research Network ◽

Significant Heterogeneity ◽

Test Results ◽

Negative Results ◽

Genomic Test ◽

Large Numbers ◽

Content Review ◽

Randomized trial of web-based genetic education versus usual care in advanced cancer patients undergoing tumor genetic testing: Results from the ECOG-ACRIN NCI Community Oncology Research Program (NCORP; EAQ152) COMET trial.

Journal of Clinical Oncology ◽

10.1200/jco.2020.38.15_suppl.2008 ◽

2020 ◽

Vol 38 (15_suppl) ◽

pp. 2008-2008

Author(s):

Angela R. Bradbury ◽

Ju-Whei Lee ◽

Jill B Gaieski ◽

Shuli Li ◽

Ilana F Gareen ◽

...

Keyword(s):

Genetic Testing ◽

Usual Care ◽

Genetic Test ◽

Genetic Knowledge ◽

Test Results ◽

Advanced Cancer Patients ◽

Web Based ◽

Genetic Test Results ◽

Anxiety Depression ◽

Web Intervention

2008 Background: Enthusiasm for precision oncology may obscure the complex psychosocial and ethical considerations for tumor genetic testing. Low patient genetic knowledge has been documented and heightens the risk for adverse experiences. We developed a web-based intervention to increase genetic knowledge and decrease distress among advanced cancer patients undergoing tumor genetic testing. Methods: 594 patients (80% from NCORP Community Sites) were recruited and randomized to web-intervention (n = 293) or usual care (n = 301), prior to receipt of tumor genetic test results. Primary outcomes were genetic knowledge, anxiety, depression, and cancer-specific distress measured at T0 (prior to intervention), T1 (post-intervention), T2 (after receipt of tumor results) and T3 (3 months post receipt of tumor results). Secondary outcomes included satisfaction, regret and disappointment. The effect of web-intervention was evaluated using t-test, multiple linear regression and logistic regression, with an intent-to-treat approach. Results: Patients randomized to web-intervention had better knowledge improvement than those randomized to usual care (T1-T0, p < 0.0001; T2-T0, p = 0.003). No difference was observed in change scores for anxiety, depression or cancer-specific distress. To find the moderators of intervention effect (including sex, age, education, and literacy) two 2-way interactions were noted with statistical significance: higher depression among those in the intervention arm versus the control arm for patients with lower literacy (p = 0.03); and lower cancer-specific distress among women in the intervention arm than with usual care but no such effect noted in men (p = 0.01). 71% of patients reported receiving tumor test results and this did not differ by arm. Only 20% of patients reported regret and disappointment at T2, which was more likely for those without a mutation of interest (MOI) detected vs those with a MOI detected (OR = 2.08, 95% CI, 1.13 to 3.83, p = 0.02). Conclusions: Web-based education prior to receipt of tumor genetic test results increases patient understanding of tumor genetic testing. While the intervention did not significantly reduce distress, results suggest that women who received the intervention had lower cancer-specific distress than those with usual care. Future refinements to the web-intervention are needed to address low literacy groups, men and patients with no actionable results. Clinical trial information: NCT02823652.

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VA OpenNotes: exploring the experiences of early patient adopters with access to clinical notes

Journal of the American Medical Informatics Association ◽

10.1136/amiajnl-2014-003144 ◽

2014 ◽

Vol 22 (2) ◽

pp. 380-389 ◽

Cited By ~ 63

Author(s):

Kim M Nazi ◽

Carolyn L Turvey ◽

Dawn M Klein ◽

Timothy P Hogan ◽

Susan S Woods

Keyword(s):

Healthcare Professionals ◽

Initial Assessment ◽

Healthcare Team ◽

Patient Portal ◽

Patient Access ◽

Test Results ◽

Web Based ◽

Clinical Notes ◽

Patient Awareness ◽

Online Access

Abstract Objective To explore the experience of early patient adopters who accessed their clinical notes online using the Blue Button feature of the My HealtheVet portal. Methods A web-based survey of VA patient portal users from June 22 to September 15, 2013. Results 33.5% of respondents knew that clinical notes could be viewed, and nearly one in four (23.5%) said that they had viewed their notes at least once. The majority of VA Notes users agreed that accessing their notes will help them to do a better job of taking medications as prescribed (80.1%) and be better prepared for clinic visits (88.6%). Nine out of 10 users agreed that use of visit notes will help them understand their conditions better (91.8%), and better remember the plan for their care (91.9%). In contrast, 87% disagreed that VA Notes will make them worry more, and 88.4% disagreed that access to VA Notes will be more confusing than helpful. Users who had either contacted their provider or healthcare team (11.9%) or planned to (13.5%) primarily wanted to learn more about a health issue, medication, or test results (53.7%). Conclusions Initial assessment of the patient experience within the first 9 months of availability provides evidence that patients both value and benefit from online access to clinical notes. These findings are congruent with OpenNotes study findings on a broader scale. Additional outreach and education is needed to enhance patient awareness. Healthcare professionals should author notes keeping in mind the opportunity patient access presents for enhanced communication.

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