scholarly journals Characterization of individuals at high risk of developing melanoma in Latin America: bases for genetic counseling in melanoma

2015 ◽  
Vol 18 (7) ◽  
pp. 727-736 ◽  
Author(s):  
Susana Puig ◽  
Miriam Potrony ◽  
Francisco Cuellar ◽  
Joan Anton Puig-Butille ◽  
Cristina Carrera ◽  
...  
Keyword(s):  
Latin America ◽  
Genetic Counseling ◽  
High Risk

scholarly journals Identifying and characterizing high-risk clusters in a heterogeneous ICU population with deep embedded clustering

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
José Castela Forte ◽  
Galiya Yeshmagambetova ◽  
Maureen L. van der Grinten ◽  
Bart Hiemstra ◽  
Thomas Kaufmann ◽  
...  
Keyword(s):  
Machine Learning ◽  
High Risk ◽  
Mortality Risk ◽  
Clustering Algorithms ◽  
Kidney Injury ◽  
Risk Groups ◽  
Admission Diagnosis ◽  
Dutch Hospital ◽  
Cluster Membership

AbstractCritically ill patients constitute a highly heterogeneous population, with seemingly distinct patients having similar outcomes, and patients with the same admission diagnosis having opposite clinical trajectories. We aimed to develop a machine learning methodology that identifies and provides better characterization of patient clusters at high risk of mortality and kidney injury. We analysed prospectively collected data including co-morbidities, clinical examination, and laboratory parameters from a minimally-selected population of 743 patients admitted to the ICU of a Dutch hospital between 2015 and 2017. We compared four clustering methodologies and trained a classifier to predict and validate cluster membership. The contribution of different variables to the predicted cluster membership was assessed using SHapley Additive exPlanations values. We found that deep embedded clustering yielded better results compared to the traditional clustering algorithms. The best cluster configuration was achieved for 6 clusters. All clusters were clinically recognizable, and differed in in-ICU, 30-day, and 90-day mortality, as well as incidence of acute kidney injury. We identified two high mortality risk clusters with at least 60%, 40%, and 30% increased. ICU, 30-day and 90-day mortality, and a low risk cluster with 25–56% lower mortality risk. This machine learning methodology combining deep embedded clustering and variable importance analysis, which we made publicly available, is a possible solution to challenges previously encountered by clustering analyses in heterogeneous patient populations and may help improve the characterization of risk groups in critical care.

scholarly journals The Role of [18F]Fluciclovine PET/CT in the Characterization of High-Risk Primary Prostate Cancer: Comparison with [11C]Choline PET/CT and Histopathological Analysis

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1575
Author(s):  
Lucia Zanoni ◽  
Riccardo Mei ◽  
Lorenzo Bianchi ◽  
Francesca Giunchi ◽  
Lorenzo Maltoni ◽  
...  
Keyword(s):  
Bone Marrow ◽  
High Risk ◽  
Malignant Lesion ◽  
Lesion Detection ◽  
Histopathological Analysis ◽  
Choline Pet ◽  
Primary Prostate Cancer ◽  
Pet Ct

The primary aim of the study was to evaluate the role of [18F]Fluciclovine PET/CT in the characterization of intra-prostatic lesions in high-risk primary PCa patients eligible for radical prostatectomy, in comparison with conventional [11C]Choline PET/CT and validated by prostatectomy pathologic examination. Secondary aims were to determine the performance of PET semi-quantitative parameters (SUVmax; target-to-background ratios [TBRs], using abdominal aorta, bone marrow and liver as backgrounds) for malignant lesion detection (and best cut-off values) and to search predictive factors of malignancy. A six sextants prostate template was created and used by PET readers and pathologists for data comparison and validation. PET visual and semi-quantitative analyses were performed: for instance, patient-based, blinded to histopathology; subsequently lesion-based, un-blinded, according to the pathology reference template. Among 19 patients included (mean age 63 years, 89% high and 11% very-high-risk, mean PSA 9.15 ng/mL), 45 malignant and 31 benign lesions were found and 19 healthy areas were selected (n = 95). For both tracers, the location of the “blinded” prostate SUVmax matched with the lobe of the lesion with the highest pGS in 17/19 cases (89%). There was direct correlation between [18F]Fluciclovine uptake values and pISUP. Overall, lesion-based (n = 95), the performance of PET semiquantitative parameters, with either [18F]Fluciclovine or [11C]Choline, in detecting either malignant/ISUP2-5/ISUP4-5 PCa lesions, was moderate and similar (AUCs ≥ 0.70) but still inadequate (AUCs ≤ 0.81) as a standalone staging procedure. A [18F]Fluciclovine TBR-L3 ≥ 1.5 would depict a clinical significant lesion with a sensitivity and specificity of 85% and 68% respectively; whereas a SUVmax cut-off value of 4 would be able to identify a ISUP 4-5 lesion in all cases (sensitivity 100%), although with low specificity (52%). TBRs (especially with threshold significantly higher than aorta and slightly higher than bone marrow), may be complementary to implement malignancy targeting.

Characterization of multidrug-resistant and virulent Klebsiella pneumoniae strains belonging to the high-risk clonal group 258 (CG258) isolated from inpatients in northeastern Brazil

2021 ◽  
Author(s):  
Rafael Nakamura-Silva ◽  
Mariana Oliveira-Silva ◽  
João Pedro Rueda Furlan ◽  
Eliana Guedes Stehling ◽  
Carlos Eduardo Saraiva Miranda ◽  
...  
Keyword(s):  
High Risk ◽  
Klebsiella Pneumoniae ◽  
Multidrug Resistant ◽  
Northeastern Brazil ◽  
Clonal Group

scholarly journals Implementing Telemedicine Visits in an Underserved Ophthalmology Clinic in the COVID-19 Era

2021 ◽  
Vol 12 ◽  
pp. 215013272199627
Author(s):  
Mona Adeli ◽  
William R. Bloom
Keyword(s):  
Latin America ◽  
High Risk ◽  
Vulnerable Populations ◽  
Low Income ◽  
Office Visit ◽  
Medically Underserved ◽  
Uninsured Patients ◽  
Potential Barriers ◽  
Ocular Morbidity

Introduction: Many of the potential barriers to providing telehealth services already disproportionately impact vulnerable populations. The purpose of this study was to assess the incorporation of synchronous ophthalmology telemedicine visits in a tertiary university-based ophthalmology clinic for low-income and uninsured patients in the COVID-19 era. Methods: The records of 18 patients who were due for an in-person visit in the medically underserved patient clinic at our institute were reviewed. Patients considered high risk of ocular morbidity progression were approved to proceed with an in-person visit. Patients with non-urgent visit indications were attempted to be contacted by telephone to be offered a telemedicine telephone visit as an alternative to a postponed in-person office visit. Results: Clinical triage by an attending ophthalmologist determined that 17 patients (94.4%, n = 18) had visit indications appropriate for evaluation by telemedicine. Six patients (35.3%, n = 17) were successfully contacted and offered a telemedicine visit as an alternative to a postponed in-person office visit. All 6 patients accepted, scheduled, and completed a telemedicine visit. Eleven patients (64.7%, n = 17) were not able to be successfully contacted to offer and schedule either a telemedicine visit or a postponed in-person office visit. Patients who were not able to be successfully contacted were on average younger in age and more likely to be female, Hispanic/Latino, from Latin America, with a preferred language of Spanish. Conclusions: Synchronous ophthalmology telemedicine visits can be successfully incorporated in a tertiary university-based setting for low-income and uninsured patients. The primary barrier to providing telemedicine visits in this population was the ability to successfully contact patients to offer and schedule these visits.

The characterization of asthma with blood eosinophilia in adults in Latin America

2018 ◽  
Vol 56 (11) ◽  
pp. 1138-1146
Author(s):  
Martín Bedolla-Barajas ◽  
José Raúl Ortiz-Peregrina ◽  
Dante Daniel Hernández-Colín ◽  
Jaime Morales-Romero ◽  
Tonatiuh Ramses Bedolla-Pulido ◽  
...  
Keyword(s):  
Latin America ◽  
Blood Eosinophilia

965: Characterization of breast cancer (BC) predisposition variants in high risk BRCA1- and BRCA2-negative BC patients using panel next-gen sequencing

2014 ◽  
Vol 50 ◽  
pp. S235-S236
Author(s):  
F. Lhota ◽  
P. Boudova ◽  
V. Stranecky ◽  
J. Soukupova ◽  
P. Kleiblova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Brca1 And Brca2 ◽  
Next Gen Sequencing

Correlates of Depressive Symptoms Among Women Seeking Cancer Genetic Counseling and Risk Assessment at a High-Risk Cancer Clinic

2006 ◽  
Vol 15 (4) ◽  
pp. 267-276 ◽  
Author(s):  
Molly Middlecamp Kodl ◽  
Judith W. Lee ◽  
Alicia K. Matthews ◽  
Shelly A. Cummings ◽  
Olufunmilayo I. Olopade
Keyword(s):  
Risk Assessment ◽  
Genetic Counseling ◽  
Depressive Symptoms ◽  
High Risk ◽  
Cancer Genetic Counseling ◽  
Cancer Genetic ◽  
High Risk Cancer ◽  
Cancer Clinic

scholarly journals Characterization of an emergent high-risk KPC-producing Klebsiella pneumoniae lineage causing a fatal wound infection after spine surgery

2021 ◽  
pp. 105122
Author(s):  
Luana Boff ◽  
Humberlânia de Sousa Duarte ◽  
Gabriela Bergiante Kraychete ◽  
Mayara Gil de Castro Santos ◽  
Rossiane Claudia Vommaro ◽  
...  
Keyword(s):  
High Risk ◽  
Klebsiella Pneumoniae ◽  
Wound Infection ◽  
Spine Surgery
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