scholarly journals The undiscovered country: the future of integrating genomic information into the EHR

2013 ◽  
Vol 15 (10) ◽  
pp. 842-845 ◽  
Author(s):  
Joseph L. Kannry ◽  
Marc S. Williams
2020 ◽  
Vol 48 (1) ◽  
pp. 151-160
Author(s):  
Henry T. Greely

Direct-to-Consumer (“DTC”) genomics has been a controversial topic for over a decade. Much work has been done on the legal issues it raises. This article asks a different question: What will DTC genomics and its legal issues look like in ten to twenty years? After discussing the five current uses of DTC genomics, it describes three current legal issues: medical uses, privacy of genomic information, and privacy in collection and analysis of human DNA. It then suggests that changes in human genomics and how it is used will make the first of those DTC genomics legal issues less important in the future, but that the third will be increasingly significant.


2010 ◽  
Vol 11 (2) ◽  
pp. 161-165 ◽  
Author(s):  
Alan E. Guttmacher ◽  
Amy L. McGuire ◽  
Bruce Ponder ◽  
Kári Stefánsson

2005 ◽  
Vol 2005 ◽  
pp. 237-237
Author(s):  
T. H. E. Meuwissen

Genetic evaluations have come a long way during the past decades, where the development and implementation of Best Linear Unbiased Prediction (BLUP) was undoubtedly the most notable achievement. The most important advances during the past 10 years were probably the direct use of test-day data in the BLUP model, ie. test-day models, the correction for heterogeneous within herd variances, multiple across country genetic evaluations (MACE), and the inclusion of more and more functional, and often difficult, traits in the evaluations. This paper will review the developments in test-day models, and the future of the genetic evaluations field, namely the inclusion of genomic information in the evaluations.


1961 ◽  
Vol 13 ◽  
pp. 29-41
Author(s):  
Wm. Markowitz
Keyword(s):  

A symposium on the future of the International Latitude Service (I. L. S.) is to be held in Helsinki in July 1960. My report for the symposium consists of two parts. Part I, denoded (Mk I) was published [1] earlier in 1960 under the title “Latitude and Longitude, and the Secular Motion of the Pole”. Part II is the present paper, denoded (Mk II).


1978 ◽  
Vol 48 ◽  
pp. 387-388
Author(s):  
A. R. Klemola
Keyword(s):  

Second-epoch photographs have now been obtained for nearly 850 of the 1246 fields of the proper motion program with centers at declination -20° and northwards. For the sky at 0° and northward only 130 fields remain to be taken in the next year or two. The 270 southern fields with centers at -5° to -20° remain for the future.


Author(s):  
Godfrey C. Hoskins ◽  
Betty B. Hoskins

Metaphase chromosomes from human and mouse cells in vitro are isolated by micrurgy, fixed, and placed on grids for electron microscopy. Interpretations of electron micrographs by current methods indicate the following structural features.Chromosomal spindle fibrils about 200Å thick form fascicles about 600Å thick, wrapped by dense spiraling fibrils (DSF) less than 100Å thick as they near the kinomere. Such a fascicle joins the future daughter kinomere of each metaphase chromatid with those of adjacent non-homologous chromatids to either side. Thus, four fascicles (SF, 1-4) attach to each metaphase kinomere (K). It is thought that fascicles extend from the kinomere poleward, fray out to let chromosomal fibrils act as traction fibrils against polar fibrils, then regroup to join the adjacent kinomere.


Author(s):  
Nicholas J Severs

In his pioneering demonstration of the potential of freeze-etching in biological systems, Russell Steere assessed the future promise and limitations of the technique with remarkable foresight. Item 2 in his list of inherent difficulties as they then stood stated “The chemical nature of the objects seen in the replica cannot be determined”. This defined a major goal for practitioners of freeze-fracture which, for more than a decade, seemed unattainable. It was not until the introduction of the label-fracture-etch technique in the early 1970s that the mould was broken, and not until the following decade that the full scope of modern freeze-fracture cytochemistry took shape. The culmination of these developments in the 1990s now equips the researcher with a set of effective techniques for routine application in cell and membrane biology.Freeze-fracture cytochemical techniques are all designed to provide information on the chemical nature of structural components revealed by freeze-fracture, but differ in how this is achieved, in precisely what type of information is obtained, and in which types of specimen can be studied.


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