scholarly journals Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy

2008 ◽  
Vol 9 (3) ◽  
pp. 224-230 ◽  
Author(s):  
H Wu ◽  
I Romieu ◽  
J-J Sienra-Monge ◽  
B E del Rio-Navarro ◽  
L Burdett ◽  
...  
Keyword(s):  
Genetic Variation ◽  
G Protein ◽  
Childhood Asthma ◽  
G Protein Coupled Receptor ◽  
Asthma Susceptibility ◽  
G Protein Coupled

G protein‐coupled receptor for asthma susceptibility associates with respiratory distress syndrome

2006 ◽  
Vol 38 (5) ◽  
pp. 357-366 ◽  
Author(s):  
Ville Pulkkinen ◽  
Ritva Haataja ◽  
Ulf Hannelius ◽  
Otto Helve ◽  
Olli M. Pitkänen ◽  
...  
Keyword(s):  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
G Protein ◽  
Distress Syndrome ◽  
G Protein Coupled Receptor ◽  
Asthma Susceptibility ◽  
G Protein Coupled

743: Genetic variation in G-protein coupled receptor kinase-5 and preeclampsia

2009 ◽  
Vol 201 (6) ◽  
pp. S267-S268
Author(s):  
Geeta K. Swamy ◽  
Melanie E. Garrett ◽  
Allison E. Ashley-Koch ◽  
Marie Lynn Miranda
Keyword(s):  
Genetic Variation ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Homeostasis of the intervertebral disc requires regulation of STAT3 signaling by the adhesion G-protein coupled receptor ADGRG6

2019 ◽  
Author(s):  
Zhaoyang Liu ◽  
Garrett W.D. Easson ◽  
Jingjing Zhao ◽  
Nadja Makki ◽  
Nadav Ahituv ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Animal Models ◽  
Intervertebral Disc ◽  
G Protein ◽  
Disc Degeneration ◽  
G Protein Coupled Receptor ◽  
Genetic Mouse Model ◽  
Stat3 Signaling ◽  
Progression Of Disease ◽  
G Protein Coupled

AbstractDegenerative changes of the intervertebral disc (IVD) are a leading cause of disability affecting humans worldwide. While this is primarily attributed to trauma and aging, genetic variation is associated with disc degeneration in humans. However, the precise mechanisms driving the initiation and progression of disease remain elusive due to a paucity of genetic animal models. Here, we discuss a novel genetic mouse model of endplate-oriented disc degeneration. We show that the adhesion G-protein coupled receptor G6 (ADGRG6) mediates several anabolic and catabolic factors, fibrotic collagen genes, pro-inflammatory pathways, and mechanical properties of the IVD, prior to the onset of overt histopathology of these tissues. Furthermore, we found increased IL-6/STAT3 activation in the IVD and demonstrate that treatment with a chemical inhibitor of STAT3 activation ameliorates disc degeneration in these mutant mice. These findings establish ADGRG6 as a critical regulator of homeostasis of adult disc homeostasis and implicate ADGRG6 and STAT3 as promising therapeutic targets for degenerative joint diseases.Author summaryDegenerative changes of the intervertebral disc (IVD) are a leading cause of disability affecting humans worldwide. While this is primarily attributed to trauma and aging, genetic variation is associated with disc degeneration in humans. However, the precise mechanisms driving the initiation and progression of disease remain elusive due to a paucity of genetic animal models. Here, we discuss a novel genetic mouse model of endplate-oriented disc degeneration. We show that the adhesion G-protein coupled receptor G6 (ADGRG6) mediates fibrotic collagen expression, causing increased mechanical stiffness of the IVD prior to the onset of histopathology in adult mice. Furthermore, we found increased IL-6/STAT3 activation in the IVD and demonstrate that treatment with a chemical inhibitor of STAT3 activation ameliorates disc degeneration in these mutant mice. Our results demonstrate that ADGRG6 regulation of STAT3 signaling is important for IVD homeostasis, indicating potential therapeutic targets for degenerative joint disorders.

Lack of association of the G protein–coupled receptor for asthma susceptibility gene with atopic dermatitis

2005 ◽  
Vol 116 (1) ◽  
pp. 220-221 ◽  
Author(s):  
Cilla Söderhäll ◽  
Ingo Marenholz ◽  
Renate Nickel ◽  
Christoph Grüber ◽  
Rainer Kehrt ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
G Protein ◽  
Susceptibility Gene ◽  
G Protein Coupled Receptor ◽  
Asthma Susceptibility ◽  
G Protein Coupled

Vanadium compounds cause activation of G protein-coupled receptor signaling

2020 ◽  
Author(s):  
Debbie C. Crans ◽  
Duaa Althumairy ◽  
Heide Murakami ◽  
B. George Barisas ◽  
Deborah Roess
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Vanadium Compounds ◽  
G Protein Coupled
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