Complement pathway biomarkers and age-related macular degeneration

M Gemenetzi; A J Lotery

doi:10.1038/eye.2015.203

Complement pathway biomarkers and age-related macular degeneration

Eye ◽

10.1038/eye.2015.203 ◽

2015 ◽

Vol 30 (1) ◽

pp. 1-14 ◽

Cited By ~ 21

Author(s):

M Gemenetzi ◽

A J Lotery

Keyword(s):

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Complement Pathway ◽

Age Related

Download Full-text

Association between Polymorphisms of Complement Pathway Genes and Age-Related Macular Degeneration in a Chinese Population

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.12-10453 ◽

2013 ◽

Vol 54 (1) ◽

pp. 170 ◽

Cited By ~ 17

Author(s):

Lin Wu ◽

Qiushan Tao ◽

Wen Chen ◽

Zhi Wang ◽

Yanping Song ◽

...

Keyword(s):

Macular Degeneration ◽

Chinese Population ◽

Age Related Macular Degeneration ◽

Complement Pathway ◽

Age Related

Download Full-text

A Targeted Inhibitor of the Alternative Complement Pathway Reduces Angiogenesis in a Mouse Model of Age-Related Macular Degeneration

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.08-2222 ◽

2009 ◽

Vol 50 (7) ◽

pp. 3056 ◽

Cited By ~ 94

Author(s):

Ba¨rbel Rohrer ◽

Qin Long ◽

Beth Coughlin ◽

R. Brooks Wilson ◽

Yuxiang Huang ◽

...

Keyword(s):

Mouse Model ◽

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Alternative Complement Pathway ◽

Complement Pathway ◽

Age Related ◽

Alternative Complement

Download Full-text

Activation of the Alternative Complement Pathway in Vitreous is Controlled by Genetics in Age-Related Macular Degeneration

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.12-9587 ◽

2012 ◽

Vol 53 (10) ◽

pp. 6628 ◽

Cited By ~ 35

Author(s):

Kelly M. Loyet ◽

Laura E. DeForge ◽

Kenneth J. Katschke ◽

Lauri Diehl ◽

Robert R. Graham ◽

...

Keyword(s):

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Alternative Complement Pathway ◽

Complement Pathway ◽

Age Related ◽

Alternative Complement

Download Full-text

Genetic variants in complement pathway and ARMS2/HTRA1 genes and risk of age-related macular degeneration in a homogeneous population from central Greece

Ophthalmic Genetics ◽

10.3109/13816810.2015.1045525 ◽

2016 ◽

Vol 37 (3) ◽

pp. 339-344

Author(s):

A. N. Tsiloulis ◽

F. Zacharaki ◽

M. G. Kotoula ◽

D. Z. Chatzoulis ◽

M. A. Morrison ◽

...

Keyword(s):

Macular Degeneration ◽

Genetic Variants ◽

Age Related Macular Degeneration ◽

Complement Pathway ◽

Homogeneous Population ◽

Central Greece ◽

Age Related

Download Full-text

Adenovirus-mediated delivery of CD46 attenuates the alternative complement pathway on RPE: implications for age-related macular degeneration

Gene Therapy ◽

10.1038/gt.2011.6 ◽

2011 ◽

Vol 18 (6) ◽

pp. 613-621 ◽

Cited By ~ 5

Author(s):

J H Sweigard ◽

S M Cashman ◽

R Kumar-Singh

Keyword(s):

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Alternative Complement Pathway ◽

Complement Pathway ◽

Age Related ◽

Alternative Complement

Download Full-text

Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration

Science Translational Medicine ◽

10.1126/scitranslmed.aaf1443 ◽

2017 ◽

Vol 9 (395) ◽

pp. eaaf1443 ◽

Cited By ~ 72

Author(s):

Brian L. Yaspan ◽

David F. Williams ◽

Frank G. Holz ◽

Carl D. Regillo ◽

Zhengrong Li ◽

...

Keyword(s):

Macular Degeneration ◽

Geographic Atrophy ◽

Age Related Macular Degeneration ◽

Alternative Complement Pathway ◽

Complement Pathway ◽

Age Related ◽

Alternative Complement

Download Full-text

THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET

Retina ◽

10.1097/iae.0000000000001392 ◽

2017 ◽

Vol 37 (5) ◽

pp. 819-835 ◽

Cited By ~ 47

Author(s):

David S. Boyer ◽

Ursula Schmidt-Erfurth ◽

Menno van Lookeren Campagne ◽

Erin C. Henry ◽

Christopher Brittain

Keyword(s):

Macular Degeneration ◽

Therapeutic Target ◽

Geographic Atrophy ◽

Age Related Macular Degeneration ◽

Complement Pathway ◽

Age Related

Download Full-text

Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

Therapeutische Umschau ◽

10.1024/0040-5930.58.1.28 ◽

2001 ◽

Vol 58 (1) ◽

pp. 28-35 ◽

Cited By ~ 1

Author(s):

Ursula Körner-Stiefbold

Keyword(s):

Macular Degeneration ◽

Clinical Features ◽

Altersbedingte Makuladegeneration ◽

Age Related Macular Degeneration ◽

Genetische Faktoren ◽

Age Related ◽

Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

Download Full-text