scholarly journals How strong is the relationship between glaucoma, the retinal nerve fibre layer, and neurodegenerative diseases such as Alzheimer’s disease and multiple sclerosis?

Eye ◽  
2015 ◽  
Vol 29 (10) ◽  
pp. 1270-1284 ◽  
Author(s):  
E Jones-Odeh ◽  
C J Hammond
Keyword(s):  
Multiple Sclerosis ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Diseases ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer ◽  
The Relationship

Correlation between retinal nerve fibre layer thickness and white matter lesions in Alzheimer's disease

2021 ◽  
Author(s):  
L. Carazo‐Barrios ◽  
A. Archidona‐Arranz ◽  
A. Claros‐Ruiz ◽  
I García‐Basterra ◽  
FJ. Garzón‐Maldonado ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
White Matter Lesions ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

Retinal nerve fibre layer thickness changes in Alzheimer’s disease: Results from a 12-month prospective case series

2016 ◽  
Vol 629 ◽  
pp. 165-170 ◽  
Author(s):  
Alessandro Trebbastoni ◽  
Fabrizia D’Antonio ◽  
Alice Bruscolini ◽  
Michela Marcelli ◽  
Michela Cecere ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Layer Thickness ◽  
Nerve Fibre ◽  
Case Series ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Prospective Case Series ◽  
Nerve Fibre Layer

ID 338 – Retinal Nerve Fibre Layer loss is associated with disease progression in Multiple Sclerosis

2016 ◽  
Vol 127 (3) ◽  
pp. e112
Author(s):  
M. Pisa ◽  
G. Di Maggio ◽  
S. Guerrieri ◽  
R. Santangelo ◽  
S. Medaglini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Progression ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer

scholarly journals Evaluation of retinal nerve fibre layer thickness as a possible measure of diabetic retinal neurodegeneration in the EPIC-Norfolk Eye Study

2021 ◽  
pp. bjophthalmol-2021-319853
Author(s):  
Sidra Zafar ◽  
Kristen A Staggers ◽  
Jie Gao ◽  
Yao Liu ◽  
Praveen J Patel ◽  
...  
Keyword(s):  
Nerve Fibre ◽  
Structural Changes ◽  
Retinal Nerve Fibre Layer ◽  
Diabetes Diagnosis ◽  
Fibre Layer ◽  
Diabetes Status ◽  
Retinal Neurodegeneration ◽  
Nerve Fibre Layer ◽  
Diabetic Retinal Neurodegeneration ◽  
The Relationship

Background/aimsMarkers to clinically evaluate structural changes from diabetic retinal neurodegeneration (DRN) have not yet been established. To study the potential role of peripapillary retinal nerve fibre layer (pRNFL) thickness as a marker for DRN, we evaluated the relationship between diabetes, as well as glycaemic control irrespective of diabetes status and pRNFL thickness.MethodsLeveraging data from a population-based cohort, we used general linear mixed models (GLMMs) with a random intercept for patient and eye to assess the association between pRNFL thickness (measured using GDx) and demographic, systemic and ocular parameters after adjusting for typical scan score. GLMMs were also used to determine: (1) the relationship between: (A) glycated haemoglobin (HbA1c) irrespective of diabetes diagnosis and pRNFL thickness, (B) diabetes and pRNFL thickness and (2) which quadrants of pRNFL may be affected in participants with diabetes and in relation to HbA1c.Results7076 participants were included. After controlling for covariates, inferior pRNFL thickness was 0.94 µm lower (95% CI −1.28 µm to −0.60 µm), superior pRNFL thickness was 0.83 µm lower (95% CI −1.17 µm to −0.49 µm) and temporal pRNFL thickness was 1.33 µm higher (95% CI 0.99 µm to 1.67 µm) per unit increase in HbA1c. Nasal pRNFL thickness was not significantly associated with HbA1c (p=0.23). Similar trends were noted when diabetes was used as the predictor.ConclusionSuperior and inferior pRNFL was significantly thinner among those with higher HbA1c levels and/or diabetes, representing areas of the pRNFL that may be most affected by diabetes.

scholarly journals Decreased Ocular Pulse Amplitude and Retinal Nerve Fibre Layer in Multiple Sclerosis

2013 ◽  
Vol 37 (3) ◽  
pp. 95-99
Author(s):  
Ebru N. Cetin ◽  
Cagdas Erdogan ◽  
Semra Acer ◽  
Gülden Sarac ◽  
Cem Yıldırım ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Nerve Fibre ◽  
Pulse Amplitude ◽  
Retinal Nerve Fibre Layer ◽  
Ocular Pulse Amplitude ◽  
Fibre Layer ◽  
Nerve Fibre Layer ◽  
Ocular Pulse

scholarly journals The relationship between Rarebit perimetry and OCT-derived retinal nerve fibre layer thickness in glaucoma

2008 ◽  
Vol 86 (8) ◽  
pp. 871-876 ◽  
Author(s):  
Andreas Katsanos ◽  
Georgios Labiris ◽  
Michael Fanariotis ◽  
Theodora Tsirouki ◽  
Dimitrios Chatzoulis
Keyword(s):  
Layer Thickness ◽  
Nerve Fibre ◽  
Retinal Nerve Fibre Layer ◽  
Fibre Layer ◽  
Nerve Fibre Layer ◽  
The Relationship
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