scholarly journals Spontaneous improvement in myopic foveoschisis

Eye ◽  
2014 ◽  
Vol 28 (12) ◽  
pp. 1519-1520 ◽  
Author(s):  
Y M Paulus ◽  
N M Bressler
Keyword(s):  
Myopic Foveoschisis ◽  
Spontaneous Improvement

scholarly journals Spontaneous improvement of carbohydrate-deficient transferrin in PMM2-CDG without mannose observed in CDG natural history study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Peter Witters ◽  
Andrew C. Edmondson ◽  
Christina Lam ◽  
Christin Johnsen ◽  
Marc C. Patterson ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Natural History ◽  
Randomized Study ◽  
Short Term ◽  
Double Blind ◽  
Natural History Study ◽  
Natural History Studies ◽  
Carbohydrate Deficient Transferrin ◽  
Spontaneous Improvement

AbstractA recent report on long-term dietary mannose supplementation in phosphomannomutase 2 deficiency (PMM2-CDG) claimed improved glycosylation and called for double-blind randomized study of the dietary supplement in PMM2-CDG patients. A lack of efficacy of short-term mannose supplementation in multiple prior reports challenge this study’s conclusions. Additionally, some CDG types have previously been reported to demonstrate spontaneous improvement in glycosylated biomarkers, including transferrin. We have likewise observed improvements in transferrin glycosylation without mannose supplementation. This observation questions the reliability of transferrin as a therapeutic outcome measure in clinical trials for PMM2-CDG. We are concerned that renewed focus on mannose therapy in PMM2-CDG will detract from clinical trials of more promising therapies. Approaches to increase efficiency of clinical trials and ultimately improve patients’ lives requires prospective natural history studies and identification of reliable biomarkers linked to clinical outcomes in CDG. Collaborations with patients and families are essential to identifying meaningful study outcomes.

Relationship between integrity of Henle fibers and visual acuity in myopic foveoschisis

Retina ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Antonio García-Ben ◽  
Isabel Baquero-Aranda ◽  
Ignacio García-Basterra ◽  
José Manuel García-Campos
Keyword(s):  
Visual Acuity ◽  
Myopic Foveoschisis

JUVENILE OSTEOPOROSIS: REPORT OF A CASE INCLUDING A DESCRIPTION OF SOME METABOLIC AND MICRORADIOGRAPHIC STUDIES

PEDIATRICS ◽  
1967 ◽  
Vol 40 (4) ◽  
pp. 649-655
Author(s):  
Mark D. Cloutier ◽  
Alvin B. Hayles ◽  
B. Lawrence Riggs ◽  
Jenifer Jowsey ◽  
William H. Bickel
Keyword(s):  
Bone Resorption ◽  
Biopsy Specimen ◽  
Iliac Crest ◽  
Calcium Balance ◽  
Metabolic Balance ◽  
Iliac Crest Biopsy ◽  
Normal Bone ◽  
Threefold Increase ◽  
Spontaneous Improvement ◽  
Initial Biopsy

A case of idiopathic osteoporosis in a 12-year-old girl has been reported. Quantitative microradiographic studies of a biopsy specimen of iliac crest showed normal bone formation and an almost threefold increase in the level of bone resorption. The patient was observed without treatment, and a spontaneous clinical remission with roentgenographic improvement occurred. A second iliac crest biopsy specimen, obtained 15 months after the initial biopsy at a time when roentgenographic improvement was apparent, showed a return toward normal of the level of bone resorption. Metabolic balance studies conducted at this time showed that the patient was approximately in calcium balance. Because the majority of the previously reported cases have also exhibited spontaneous improvement, it is suggested that initially observation alone is indicated.

Resolution of Optic Disc Pit Maculopathy Following Posterior Vitreous Detachment

2021 ◽  
pp. 247412642110467
Author(s):  
Ali H. Mannaa ◽  
Reda A. Issa ◽  
J. Shepard Bryan
Keyword(s):  
Optic Disc ◽  
Posterior Vitreous Detachment ◽  
Interesting Case ◽  
Optic Disc Pit ◽  
Review Of The Literature ◽  
Fluid Accumulation ◽  
Optic Pit ◽  
Vitreous Detachment ◽  
Spontaneous Improvement ◽  
Optic Disc Pit Maculopathy

Purpose: This work presents a case of significant improvement of optic pit disc maculopathy following an acute posterior vitreous detachment (PVD) and discusses the possible mechanisms of this phenomenon. Methods: A case report and review of the literature are presented. Results: A 56-year-old man presenting with progressive visual decline in his left eye was found to have an optic disc pit with optical coherence tomography (OCT) evidence of severe intraretinal edema and maculoschisis. His visual acuity and macular anatomy on OCT improved dramatically in the months following a PVD. Conclusions: This report presents an interesting case of spontaneous improvement of optic disc pit–related maculopathy following PVD. We discuss the cause of the retinal fluid accumulation in optic disc pit maculopathy and consider that the OCT findings in our case lend credence to the theory that this fluid originates from the vitreous humor.

Iatrogenic Superior Vena Cava Syndrome With Spontaneous Improvement

1979 ◽  
Vol 72 (7) ◽  
pp. 876-877
Author(s):  
ALI SHIRKHODA ◽  
BRUCE E. RUBIN ◽  
MOHAMMAD B. G. SHAHVARI
Keyword(s):  
Superior Vena Cava ◽  
Superior Vena Cava Syndrome ◽  
Superior Vena ◽  
Vena Cava ◽  
Vena Cava Syndrome ◽  
Spontaneous Improvement

scholarly journals Significance of Crescentic Glomeruli in Acute Kidney Injury with Rheumatoid Arthritis

2019 ◽  
Vol 9 (1) ◽  
pp. 42-48
Author(s):  
Ali Ayaash ◽  
Dipesh Maan ◽  
Anastasios Kapetanos ◽  
Mark Bunker ◽  
Mary Chester Wasko ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Acute Kidney Injury ◽  
Kidney Injury ◽  
Renal Outcome ◽  
Primary Role ◽  
Tubular Necrosis ◽  
Immune Mediated ◽  
Autoimmune Conditions ◽  
Spontaneous Improvement

Crescentic glomerulonephritis (GN) without immune reactants or deposits (referred to as pauci-immune) is typically characterized by the presence of anti-neutrophilic cytoplasmic antibodies (ANCA). While ANCA-negative patients might be expected to have a more benign course, they often have poor renal outcomes, especially without treatment with steroids and immune-modulating therapy. Pauci-immune crescentic GN can also co-exist with other autoimmune conditions, including rheumatoid arthritis (RA). Here, we describe an ANCA-negative patient with RA who developed dialysis-requiring acute kidney injury (AKI) with findings consistent with focal pauci-immune crescentic GN (i.e., no IgG or immune complex on kidney biopsy). Coexistent conditions included Klebsiella sepsis attributed to pneumonia, rhabdomyolysis, leukocytoclastic immune-mediated skin vasculitis, and positive ANA. He had spontaneous improvement in renal function without immunosuppressive therapy. This crescentic GN was not associated with poor renal outcome as AKI resolved with supportive care and treatment of his infection. The AKI was likely multifactorial with co-existing acute tubular necrosis in the setting of Kebsiella sepsis and rhabdomyolysis, and the crescentic GN was felt more likely to be related to the infection rather than having a primary role. This case highlights the importance of viewing crescentic GN in the context of the clinical picture, as it may not always lead to the need of aggressive immune suppression and is not a universally poor prognostic kidney finding. However, these cases do warrant close follow-up as our patient had recurrent RA disease manifestations over the next 2 years that eventually led to his death from severe pulmonary hypertension.

scholarly journals Deterioration Following Spontaneous Improvement

Stroke ◽  
2000 ◽  
Vol 31 (4) ◽  
pp. 915-919 ◽  
Author(s):  
Andrei V. Alexandrov ◽  
Robert A. Felberg ◽  
Andrew M. Demchuk ◽  
Ioannis Christou ◽  
W. Scott Burgin ◽  
...  
Keyword(s):  
Spontaneous Improvement

scholarly journals Spontaneous Improvement of Visual Function in Suprasellar Meningioma

2021 ◽  
Vol 62 (3) ◽  
pp. 414-418
Author(s):  
Dong Seon Kim ◽  
Sang Woo Moon ◽  
Hie Bum Suh ◽  
Hyeshin Jeon ◽  
Hee-Young Choi
Keyword(s):  
Visual Function ◽  
Spontaneous Improvement
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