scholarly journals The effect of once-daily latanoprost on intraocular pressure and pulsatile ocular blood flow in normal tension glaucoma

Eye ◽  
1999 ◽  
Vol 13 (1) ◽  
pp. 31-34 ◽  
Author(s):  
M McKibbin ◽  
M J Menage
Keyword(s):  
Blood Flow ◽  
Intraocular Pressure ◽  
Normal Tension Glaucoma ◽  
Ocular Blood Flow ◽  
Once Daily ◽  
Pulsatile Ocular Blood Flow

Ocular Rigidity, Ocular Pulse Amplitude, and Pulsatile Ocular Blood Flow: The Effect of Intraocular Pressure

2009 ◽  
Vol 50 (12) ◽  
pp. 5718 ◽  
Author(s):  
Anna I. Dastiridou ◽  
Harilaos S. Ginis ◽  
Dirk De Brouwere ◽  
Miltiadis K. Tsilimbaris ◽  
Ioannis G. Pallikaris
Keyword(s):  
Blood Flow ◽  
Intraocular Pressure ◽  
Pulse Amplitude ◽  
Ocular Blood Flow ◽  
Ocular Pulse Amplitude ◽  
Pulsatile Ocular Blood Flow ◽  
Ocular Pulse

The short-term effect of latanoprost on intraocular pressure and pulsatile ocular blood flow

2002 ◽  
Vol 80 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Gerasimos T. Georgopoulos ◽  
Michael Diestelhorst ◽  
Robert Fisher ◽  
Peter Ruokonen ◽  
Guenter K. Krieglstein
Keyword(s):  
Blood Flow ◽  
Intraocular Pressure ◽  
Ocular Blood Flow ◽  
Term Effect ◽  
Short Term ◽  
Short Term Effect ◽  
Pulsatile Ocular Blood Flow

Four Years Later: A Clinical Update on Latanoprost

2003 ◽  
Vol 13 (2) ◽  
pp. 162-175 ◽  
Author(s):  
E. Ravinet ◽  
A. Mermoud ◽  
R. Brignoli
Keyword(s):  
Blood Flow ◽  
Open Angle Glaucoma ◽  
Cataract Extraction ◽  
Normal Tension Glaucoma ◽  
Ocular Blood Flow ◽  
Ciliary Muscle ◽  
Angle Closure ◽  
Pigmentary Glaucoma ◽  
Long Term Treatment ◽  
Pulsatile Ocular Blood Flow

Purpose Almost five years have elapsed since the introduction of latanoprost on several markets and considering the large number of publications dealing with it, the authors felt that it was worth re-evaluating the drug. Methods The criterion used to select trials for inclusion in the review was: all articles mentioning the drug in common electronic data-bases; these were then screened and considered, on the basis of methodological quality. Results Experimental data suggest that latanoprost acts by remodeling the extracellular matrix in the ciliary muscle, thus increasing the flow of aqueous humor through the ciliary muscle bundles of the uveoscleral pathway. POAG Latanoprost persistently improves the pulsatile ocular blood flow in primary open angle glaucoma (POAG). Recent trials confirmed the greater IOP-lowering efficacy of latanoprost vs. timolol, dorzolamide, brimonidine and unoprostone. Trials lasting up to 24 months showed that latanoprost is effective in long-term treatment of POAG and ocular hypertension (OH), with no signs of loss of efficacy when compared to timolol or dorzolamide. Latanoprost provides better control of circadian IOP. Non-responders to b-blockers should preferably be switched to latanoprost monotherapy before a combination therapy is started. The possibility of a fixed combination of latanoprost and timolol has been explored, with promising results. NTG Latanoprost is effective in normal tension glaucoma (NTG), lowering IOP, improving pulsatile ocular blood flow and increasing ocular perfusion pressure. Other Glaucomas Latanoprost may provide effective IOP control in angle-closure glaucoma after iridectomy, in pigmentary glaucoma, glaucoma after cataract extraction and steroid-induced glaucoma. However, latanoprost was effective in only a minority of pediatric cases of glaucoma and is contraindicated in all forms of uveitic glaucoma. Safety In the articles reviewed, new or duration-related adverse events were reported.

Sign in / Sign up

Export Citation Format

Share Document