scholarly journals Role of intravitreal dexamethasone in exogenous fungal endophthalmitis

Eye ◽  
1999 ◽  
Vol 13 (5) ◽  
pp. 660-665 ◽  
Author(s):  
Ajit B Majji ◽  
Subhadra Jalali ◽  
Taraprasad Das ◽  
Usha Gopinathan
Keyword(s):  
Fungal Endophthalmitis ◽  
Exogenous Fungal Endophthalmitis ◽  
Intravitreal Dexamethasone

scholarly journals Long-term visual outcomes of endophthalmitis and the role of systemic steroids in addition to intravitreal dexamethasone

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Christopher D. Conrady ◽  
Richard M. Feist ◽  
Albert T. Vitale ◽  
Akbar Shakoor
Keyword(s):  
Systemic Steroids ◽  
Visual Outcomes ◽  
Intravitreal Dexamethasone

Exogenous Fungal Endophthalmitis: An Analysis of Isolates and Susceptibilities to Antifungal Agents Over a 20-Year Period (1990–2010)

2015 ◽  
Vol 159 (2) ◽  
pp. 257-264.e1 ◽  
Author(s):  
Ruwan A. Silva ◽  
Jayanth Sridhar ◽  
Darlene Miller ◽  
Charles C. Wykoff ◽  
Harry W. Flynn
Keyword(s):  
Antifungal Agents ◽  
Fungal Endophthalmitis ◽  
Exogenous Fungal Endophthalmitis

ROLE OF EARLY VITRECTOMY IN THE TREATMENT OF FUNGAL ENDOPHTHALMITIS

Retina ◽  
2018 ◽  
Vol 38 (7) ◽  
pp. 1385-1392 ◽  
Author(s):  
Umesh Chandra Behera ◽  
Monica Budhwani ◽  
Taraprasad Das ◽  
Soumyava Basu ◽  
Tapas Ranjan Padhi ◽  
...  
Keyword(s):  
Fungal Endophthalmitis ◽  
Early Vitrectomy

scholarly journals Persistently Vitreous Culture–Positive Exogenous Fungal Endophthalmitis

2016 ◽  
Vol 172 ◽  
pp. 45-50 ◽  
Author(s):  
Ella H. Leung ◽  
Ajay E. Kuriyan ◽  
Harry W. Flynn ◽  
Nidhi Relhan ◽  
Laura C. Huang ◽  
...  
Keyword(s):  
Fungal Endophthalmitis ◽  
Exogenous Fungal Endophthalmitis ◽  
Culture Positive

Endophthalmitis associated with fungal keratitis and penetrating injuries in North China

2019 ◽  
Vol 30 (3) ◽  
pp. 455-461 ◽  
Author(s):  
Meng-Yang Liu ◽  
Li Zhang ◽  
Xiao-Lin Yin ◽  
Shi-Ying Sun
Keyword(s):  
Visual Acuity ◽  
Amphotericin B ◽  
Antifungal Therapy ◽  
Fungal Pathogens ◽  
North China ◽  
Penetrating Trauma ◽  
Fungal Keratitis ◽  
Laboratory Findings ◽  
Fungal Endophthalmitis ◽  
Exogenous Fungal Endophthalmitis

Purpose: To report the laboratory findings, management strategies, and visual outcomes of culture-proven exogenous fungal endophthalmitis in North China. Methods: The microbiological and treatment records of patients with culture-positive exogenous fungal endophthalmitis who visited the Affiliated Hospital of Qingdao University from January 2012 to December 2016 were reviewed. Results: A total of 39 eyes (39 patients) were identified over a 5-year period. Exogenous fungal endophthalmitis was associated with penetrating trauma in 22 eyes (56.4%), fungal keratitis in 15 eyes (38.5%), and intraocular surgery in 2 eyes (5.1%). Hyphae were found in 29 of 37 smear samples (78.4%) by direct microscopic examination. Fungal pathogens cultured from 39 samples were identified as 10 genera and 15 species. Filamentous fungi (molds) accounted for 94.9% (37 samples), including Fusarium (19, 48.7%) and Aspergillus (11, 28.2%). Most keratitis cases were caused by Fusarium (11 of 15; 73.3 %). Aspergillus was isolated from nine penetrating ocular trauma cases (9 of 22; 40.9%). Three eyes receiving evisceration had fungal and bacteria coinfection (3 of 39, 7.7%) with Aspergillus and Bacillus. At least, one surgical intervention was performed in all 39 eyes and 28 (71.8%) eyes underwent two or more procedures, including surgeries and intraocular injections. Twenty-nine patients received intraocular antifungal therapy with amphotericin B and/or voriconazole. Visual acuity at discharge from the hospital was significantly better than the initial visual acuity ( p < 0.001). Final vision of 20/400 or better was achieved in 22 (56.4%) eyes. Conclusions: This study highlighted the differences between clinical categories of exogenous fungal endophthalmitis. Trauma was the major etiological factor. Molds were the most common pathogens, with Fusarium ranking first, followed by Aspergillus. Fungal and bacterial coinfection mostly occurred after metal penetrating trauma, and Bacillus was the primary bacterial pathogen. Coinfection may be one reason of evisceration. Immediate intravitreal antifungal therapy combined with vitrectomy was effective for exogenous fungal endophthalmitis. Amphotericin B and voriconazole were commonly used antifungal agents.

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