scholarly journals Mitochondrial DNA disease masquerading as age-related macular degeneration

Eye ◽  
1999 ◽  
Vol 13 (4) ◽  
pp. 595-596
Author(s):  
R M Andrews ◽  
B J McNeela ◽  
P Reading ◽  
P G Griffiths ◽  
P F Chinnery ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related

Mitochondrial DNA Haplogroups Associated with Age-Related Macular Degeneration

2009 ◽  
Vol 50 (6) ◽  
pp. 2966 ◽  
Author(s):  
Nitin Udar ◽  
Shari R. Atilano ◽  
Masood Memarzadeh ◽  
David S. Boyer ◽  
Marilyn Chwa ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related

Characterization of Retinal and Blood Mitochondrial DNA from Age-Related Macular Degeneration Patients

2010 ◽  
Vol 51 (8) ◽  
pp. 4289 ◽  
Author(s):  
M. Cristina Kenney ◽  
Shari R. Atilano ◽  
David Boyer ◽  
Marilyn Chwa ◽  
Garrick Chak ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Mitochondrial DNA haplogroups confer differences in risk for age-related macular degeneration: a case control study

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
M Cristina Kenney ◽  
Dieter Hertzog ◽  
Garrick Chak ◽  
Shari R Atilano ◽  
Nikan Khatibi ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Macular Degeneration ◽  
Case Control Study ◽  
Case Control ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Control Study

scholarly journals Mitochondrial DNA Damage as a Potential Mechanism for Age-Related Macular Degeneration

2010 ◽  
Vol 51 (11) ◽  
pp. 5470 ◽  
Author(s):  
Pabalu P. Karunadharma ◽  
Curtis L. Nordgaard ◽  
Timothy W. Olsen ◽  
Deborah A. Ferrington
Keyword(s):  
Dna Damage ◽  
Mitochondrial Dna ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Potential Mechanism ◽  
Mitochondrial Dna Damage ◽  
Age Related

scholarly journals Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration

PLoS ONE ◽  
2008 ◽  
Vol 3 (5) ◽  
pp. e2091 ◽  
Author(s):  
Jeffrey A. Canter ◽  
Lana M. Olson ◽  
Kylee Spencer ◽  
Nathalie Schnetz-Boutaud ◽  
Brent Anderson ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Macular Degeneration ◽  
Dna Polymorphism ◽  
Age Related Macular Degeneration ◽  
Mitochondrial Dna Polymorphism ◽  
Age Related

scholarly journals Role of Mitochondrial DNA Damage in ROS-Mediated Pathogenesis of Age-Related Macular Degeneration (AMD)

2019 ◽  
Vol 20 (10) ◽  
pp. 2374 ◽  
Author(s):  
Kai Kaarniranta ◽  
Elzbieta Pawlowska ◽  
Joanna Szczepanska ◽  
Aleksandra Jablkowska ◽  
Janusz Blasiak
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Mitochondrial Dna ◽  
Macular Degeneration ◽  
Retinal Pigment ◽  
Essential Element ◽  
Age Related Macular Degeneration ◽  
Early Event ◽  
Mitochondrial Dna Damage ◽  
Age Related

Age-related macular degeneration (AMD) is a complex eye disease that affects millions of people worldwide and is the main reason for legal blindness and vision loss in the elderly in developed countries. Although the cause of AMD pathogenesis is not known, oxidative stress-related damage to retinal pigment epithelium (RPE) is considered an early event in AMD induction. However, the precise cause of such damage and of the induction of oxidative stress, including related oxidative effects occurring in RPE and the onset and progression of AMD, are not well understood. Many results point to mitochondria as a source of elevated levels of reactive oxygen species (ROS) in AMD. This ROS increase can be associated with aging and effects induced by other AMD risk factors and is correlated with damage to mitochondrial DNA. Therefore, mitochondrial DNA (mtDNA) damage can be an essential element of AMD pathogenesis. This is supported by many studies that show a greater susceptibility of mtDNA than nuclear DNA to DNA-damaging agents in AMD. Therefore, the mitochondrial DNA damage reaction (mtDDR) is important in AMD prevention and in slowing down its progression as is ROS-targeting AMD therapy. However, we know far less about mtDNA than its nuclear counterparts. Further research should measure DNA damage in order to compare it in mitochondria and the nucleus, as current methods have serious disadvantages.

Age related macular degeneration (ARMD) – pathophysiological and clinical features and therapeutic concepts

2001 ◽  
Vol 58 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Ursula Körner-Stiefbold
Keyword(s):  
Macular Degeneration ◽  
Clinical Features ◽  
Altersbedingte Makuladegeneration ◽  
Age Related Macular Degeneration ◽  
Genetische Faktoren ◽  
Age Related ◽  
Therapeutic Concepts

Die altersbedingte Makuladegeneration (AMD) ist eine der häufigsten Ursachen für einen irreversiblen Visusverlust bei Patienten über 65 Jahre. Nahezu 30% der über 75-Jährigen sind von einer AMD betroffen. Trotz neuer Erkenntnisse in der Grundlagenforschung ist die Ätiologie, zu der auch genetische Faktoren gehören, noch nicht völlig geklärt. Aus diesem Grund sind die Behandlungsmöglichkeiten zum jetzigen Zeitpunkt noch limitiert, so dass man lediglich von Therapieansätzen sprechen kann. Die derzeit zur Verfügung stehenden Möglichkeiten wie medikamentöse, chirurgische und laser- und strahlentherapeutische Maßnahmen werden beschrieben.

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