scholarly journals An investigation of the general immune status and specific immune responsiveness to retinal—(S)—antigen in patients with chronic posterior uveitis

Eye ◽  
1989 ◽  
Vol 3 (3) ◽  
pp. 263-270 ◽  
Author(s):  
Karin S Froebel ◽  
Sylvia S Armstrong ◽  
Alison M Cliffe ◽  
S J Urbaniak ◽  
J V Forrester
Keyword(s):  
Immune Status ◽  
Posterior Uveitis ◽  
Immune Responsiveness ◽  
Specific Immune Responsiveness

scholarly journals Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

2019 ◽  
Author(s):  
Andrew R. DiNardo ◽  
Kimal Rajapakshe ◽  
Tomoki Nishiguchi ◽  
Godwin Mtetwa ◽  
Qiniso Dlamini ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Immune Cells ◽  
Methylation Status ◽  
Host Immunity ◽  
Immune Responsiveness ◽  
Chronic Infections ◽  
Household Contacts ◽  
Full Complement ◽  
Ifn Γ ◽  
Specific Immune Responsiveness

AbstractMycobacterium tuberculosis (Mtb) has co-evolved with humans for millennia and developed multiple mechanisms to evade host immunity. Restoring host immunity in order to shorten existing therapy and improve outcomes will require identifying the full complement by which host immunity is inhibited. Perturbing host DNA methylation is a mechanism induced by chronic infections such as HIV, HPV, LCMV and schistosomiasis to evade host immunity. Here, we evaluated the DNA methylation status of TB patients and their asymptomatic household contacts demonstrating that TB patients have DNA hyper-methylation of the IL-2-STAT5, TNF-NF-ϰB and IFN-γ signaling pathways. By MSRE-qPCR, multiple genes of the IL-12-IFN-γ signaling pathway (IL12B, IL12RB2, TYK2, IFNGR1, JAK1 and JAK2) were hyper-methylated in TB patients. The DNA hyper-methylation of these pathways is associated with decreased immune responsiveness with decreased mitogen induced upregulation of IFN-γ, TNF, IL-6 and IL-1β production. The DNA hyper-methylation of the IL-12-IFN-γ pathway was associated with decreased IFN-γ induced gene expression and decreased IL-12 inducible up-regulation of IFN-γ. This work demonstrates that immune cells from TB patients are characterized by DNA hyper-methylation of genes critical to mycobacterial immunity resulting in decreased mycobacteria-specific and non-specific immune responsiveness.

Heterogeneity in Filarial-Specific Immune Responsiveness among Patients with Lymphatic Obstruction

1993 ◽  
Vol 167 (5) ◽  
pp. 1178-1183 ◽  
Author(s):  
P. J. Lammie ◽  
D. G. Addiss ◽  
G. Leonard ◽  
A. W. Hightower ◽  
M. L. Eberhard
Keyword(s):  
Immune Responsiveness ◽  
Specific Immune Responsiveness ◽  
Lymphatic Obstruction

Using phytohaemagglutinin to determine immune responsiveness in saltwater crocodiles (Crocodylus porosus)

2013 ◽  
Vol 61 (4) ◽  
pp. 301 ◽  
Author(s):  
John W. Finger Jr ◽  
Amanda L. Adams ◽  
Peter C. Thomson ◽  
Cathy M. Shilton ◽  
Greg P. Brown ◽  
...  
Keyword(s):  
Agricultural Production ◽  
Immune Status ◽  
Acquired Immunity ◽  
Immune Responsiveness ◽  
Trade Offs ◽  
Crocodylus Porosus ◽  
Cellular Immune Responsiveness ◽  
Antigenic Exposure ◽  
Cellular Immune ◽  
Phosphate Buffered Saline

Immune responsiveness, the ability of an organism to effectively respond immunologically following antigenic exposure, is an essential component of life history, as organisms require effective immune functionality in order to grow, survive and reproduce. However, immune status is also associated with concomitant trade-offs in these physiological functions. Herein we demonstrate the validation of phytohaemagglutinin (PHA) injection in saltwater crocodiles, Crocodylus porosus, to assess cellular immune responsiveness. Following injection of 2 mg mL–1 PHA into the hind toe webbing, we observed a peak swelling response 12 h after injection, with PHA inducing increased thickness compared with webs injected with phosphate-buffered saline (PBS) (F5,518 = 145.13, P < 0.001). Subsequent injections increased responsiveness relative to the primary injection response (F5,290 = 2.92, P = 0.029), suggesting that PHA exposure induced immunological memory, a tenet of acquired immunity. Histological examination revealed that PHA-injected toe webs displayed increased numbers of leukocytes (granulocytes, macrophages, and lymphocytes) relative to PBS-injected webs, with peak leukocytic infiltrate observed 12 h after injection. We suggest the use of PHA injection in crocodilians as a measure of cellular immune responsiveness in agricultural (production and animal welfare), ecological, and toxicological contexts.

56-OR: Comprehensive maping (multi-analyte-profiling) of donor-specific immune responsiveness. A proteomics approach

2011 ◽  
Vol 72 ◽  
pp. S193
Author(s):  
Anat R. Tambur ◽  
Nancy D. Herrera ◽  
Kerry L. Ballard ◽  
Ralph L. McDade ◽  
Joshua Miller ◽  
...  
Keyword(s):  
Immune Responsiveness ◽  
Proteomics Approach ◽  
Specific Immune Responsiveness

Protein kinase C independent restoration of specific immune responsiveness in common variable immunodeficiency

1991 ◽  
Vol 59 (1) ◽  
pp. 26-36 ◽  
Author(s):  
Michael G. Goodman ◽  
Sudhir Gupta ◽  
Marvin E. Rosenthale ◽  
Robert J. Capetola ◽  
Stanley C. Bell ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Common Variable Immunodeficiency ◽  
Immune Responsiveness ◽  
Kinase C ◽  
Specific Immune Responsiveness ◽  
Common Variable

Immune status of patients with low efficacy of allergens immunotherapy

2004 ◽  
Author(s):  
B. J. Gumilevsky ◽  
V. N. Tzygan ◽  
O. P. Gumilevskaya
Keyword(s):  
Immune Status

Immune status is associated with the mode of delivery in infants at increased risk for Type 1 Diabetes

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
O D'Orlando ◽  
R Puff ◽  
A Henniger ◽  
S Krause ◽  
F Haupt ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Immune Status ◽  
Mode Of Delivery ◽  
Increased Risk
Sign in / Sign up

Export Citation Format

Share Document